Articles

Potential roles of vitamin D binding protein in attenuating liver injury in sepsis

In sepsis, vitamin D binding protein (VDBP) has been shown to be low-expressed. The current study examined the relationship between serum VDBP level and liver injury in sepsis patients, as well as in a mouse m...

Authors: Kun Xiao, Du-Chao Zhang, Ye Hu, Li-Cheng Song, Jian-Qiao Xu, Wan-Xue He, Pan Pan, Yu-Wei Wang and Li-Xin Xie

Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?

Bacteria can evolve rapidly by acquiring new traits such as virulence, metabolic properties, and most importantly, antimicrobial resistance, through horizontal gene transfer (HGT). Multidrug resistance in bact...

Authors: Zhen Shen, Christoph M. Tang and Guang-Yu Liu

Military traumatic brain injury: a challenge straddling neurology and psychiatry

Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiolo...

Authors: Ling-Zhuo Kong, Rui-Li Zhang, Shao-Hua Hu and Jian-Bo Lai

Autologous omentum transposition for regeneration of a renal injury model in rats

After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a r...

Authors: Tayfun Bilgiç, Ümit İnce and Fehmi Narter

Cell fusion in the pathogenesis of COVID-19

Authors: You Zheng, Lu-Lin Zhou, Yan Su and Qiang Sun

Advances in the design and development of SARS-CoV-2 vaccines

Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious ...

Authors: Xue-Liang Peng, Ji-Si-Yu Cheng, Hai-Lun Gong, Meng-Di Yuan, Xiao-Hong Zhao, Zibiao Li and Dai-Xu Wei

Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model

The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation ha...

Authors: Wei Hu, Jia-Wu Liang, Song Liao, Zhi-Dong Zhao, Yu-Xing Wang, Xiao-Fei Mao, Si-Wei Hao, Yi-Fan Wang, Heng Zhu and Bin Guo

Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model

Musculoskeletal injuries (MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during in...

Authors: Stefan Sammito, Vedran Hadzic, Thomas Karakolis, Karen R. Kelly, Susan P. Proctor, Ainars Stepens, Graham White and Wes O. Zimmermann

Estimation of radiation-induced health hazards from a “dirty bomb” attack with radiocesium under different assault and rescue conditions

In the case of a terrorist attack by a “dirty bomb”, blast injuries, external irradiation and the incorporation of radioactivity are to be expected. Departing from information about the radiological attack sce...

Authors: Alexis Rump, Stefan Eder, Cornelius Hermann, Andreas Lamkowski, Patrick Ostheim, Michael Abend and Matthias Port

Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack of comprehensive and updated...

Authors: Cong Zhu, Dan-Qi Wang, Hao Zi, Qiao Huang, Jia-Min Gu, Lu-Yao Li, Xing-Pei Guo, Fei Li, Cheng Fang, Xiao-Dong Li and Xian-Tao Zeng

Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer

Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its highly metastatic and recurrent features, as wel...

Authors: Dan-Dan Zhou, Wei-Qi Bai, Xiao-Tian Zhai, Li-Ping Sun, Yong-Su Zhen, Zhuo-Rong Li and Qing-Fang Miao

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass pe...

Authors: Xing-Yong Chen, Shao-Fen Wan, Nan-Nan Yao, Ze-Jing Lin, Yan-Guang Mao, Xiao-Hua Yu and Yin-Zhou Wang

Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019

The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...

Authors: Hao Zi, Shao-Hua He, Xie-Yuan Leng, Xiao-Feng Xu, Qiao Huang, Hong Weng, Cong Zhu, Lu-Yao Li, Jia-Min Gu, Xu-Hui Li, Dao-Jing Ming, Xiao-Dong Li, Shuai Yuan, Xing-Huan Wang, Da-Lin He and Xian-Tao Zeng

Regional trauma system development in Shenzhen, China: an 8-year journey

Authors: Gui-Xi Zhang, Gilberto Ka Kit Leung, Chung Mau Lo, Richard Kwong-Yin Lo, John Wong, Ronald V. Maier, Eileen M. Bulger, Joe King Man Fan and Xiao-Bing Fu

Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia

Administration of propofol, an intravenous anesthetic with antioxidant property, immediately at the onset of post-ischemic reperfusion (propofol postconditioning, P-PostC) has been shown to confer cardioprotec...

Authors: Rong-Hui Han, He-Meng Huang, Hong Han, Hao Chen, Fei Zeng, Xiang Xie, Dan-Yong Liu, Yin Cai, Liang-Qing Zhang, Xin Liu, Zheng-Yuan Xia and Jing Tang

The roles of exosomal immune checkpoint proteins in tumors

Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However, most patients develop adaptive resistance to this therapy. The latest evidence demonstrates ...

Authors: Cheng Xing, Heng Li, Rui-Juan Li, Le Yin, Hui-Fang Zhang, Zi-Neng Huang, Zhao Cheng, Ji Li, Zhi-Hua Wang and Hong-Ling Peng

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whet...

Authors: Yi Wu, Xian-Hui Wang, Xi-Hua Li, Li-Yuan Song, Shi-Long Yu, Zhi-Cheng Fang, Yu-Quan Liu, Le-Yong Yuan, Chun-Yan Peng, Shen-Yi Zhang, Wang Cheng, Hong-Chao Ma, Li-Feng Wang, Jun-Ming Tang, Yun-Fu Wang and Fu-Yun Ji

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeli...

Authors: Xi-Yao Chen, Yang Jiao and Fu-Yang Zhang

Dementia in military and veteran populations: a review of risk factors—traumatic brain injury, post-traumatic stress disorder, deployment, and sleep

The military population face a unique set of risk factors that may increase the risk of being diagnosed with dementia. Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) have a higher preva...

Authors: Zara Raza, Syeda F. Hussain, Suzanne Ftouni, Gershon Spitz, Nick Caplin, Russell G. Foster and Renata S. M. Gomes

Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Hea...

Authors: Biao Xu, Bo Tu, Fang Chu, Mohamed Jalloh, Jin-Song Mu, Jun-Jie Zheng and Wei-Wei Chen

Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although periodontitis and genitourinary cancers are two totally distinct types of disorders, epidemiological and clinical studi...

Authors: Shuai Yuan, Cheng Fang, Wei-Dong Leng, Lan Wu, Bing-Hui Li, Xing-Huan Wang, Hailiang Hu and Xian-Tao Zeng

A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China

To determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019 (COVID-19) patients in China. A cross-sectional study was performed in Wuhan from April 3, 2020...

Authors: Jian-Hui Li, Yi Sun, Mei-Rong Li, Hu Yuan, Chang-Liang Yang, Cheng-Cheng Huang, Feng-Jie Zhou, Rui-Yao Chen, Lei-Bo Zhang, Ning Yu, Qiong Liu, Jing-Jing He, Xue-Jun Zhou, Xiao-Bing Fu and Shi-Ming Yang

Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review

By its nature, Gulf war illness (GWI) is multisymptomatic and affects several organ systems in the body. Along with other symptoms, veterans who suffer from GWI commonly report chronic gastrointestinal issues ...

Authors: Diana A. Kimono

Antimicrobial peptides: mechanism of action, activity and clinical potential

The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicro...

Authors: Qi-Yu Zhang, Zhi-Bin Yan, Yue-Ming Meng, Xiang-Yu Hong, Gang Shao, Jun-Jie Ma, Xu-Rui Cheng, Jun Liu, Jian Kang and Cai-Yun Fu

Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelia...

Authors: Duo-Meng Yang, Ting-Ting Geng, Andrew G. Harrison and Peng-Hua Wang

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice

SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and ...

Authors: Natalie Yan-Lin Pang, Alexander Shao-Rong Pang, Vincent T. Chow and De-Yun Wang

Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls

Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.

Authors: Beatrice Alexandra Golomb, Sridevi Devaraj, Alexis K. Messner, Hayley Jean Koslik, Jun Hee Han and Barnabas Yik

Advances in single-cell sequencing: insights from organ transplantation

Single-cell RNA sequencing (scRNA-seq) is a comprehensive technical tool to analyze intracellular and intercellular interaction data by whole transcriptional profile analysis. Here, we describe the application...

Authors: Ying Wang, Jian-Ye Wang, Angelika Schnieke and Konrad Fischer

Data mining in clinical big data: the frequently used databases, steps, and methodological models

Many high quality studies have emerged from public databases, such as Surveillance, Epidemiology, and End Results (SEER), National Health and Nutrition Examination Survey (NHANES), The Cancer Genome Atlas (TCG...

Authors: Wen-Tao Wu, Yuan-Jie Li, Ao-Zi Feng, Li Li, Tao Huang, An-Ding Xu and Jun Lyu

Chronotype and self-reported sleep, alertness, and mental health in U.S. sailors

Service members are at risk for sleep and psychological conditions affecting their readiness. Chronotype (“morningness” or “eveningness”) is strongly associated with sleep, health and performance. The objectiv...

Authors: Elizabeth M. Harrison, Alexandra P. Easterling, Emily A. Schmied, Suzanne L. Hurtado and Gena L. Glickman

Traumatic brain injury and sight loss in military and veteran populations– a review

War and combat exposure pose great risks to the vision system. More recently, vision related deficiencies and impairments have become common with the increased use of powerful explosive devices and the subsequ...

Authors: Syeda F. Hussain, Zara Raza, Andrew T. G. Cash, Thomas Zampieri, Robert A. Mazzoli, Randy H. Kardon and Renata S. M. Gomes

Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study

The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure (AHF) who do not have hypoxemia. The aim of this study was to investigate the association between oxygen ther...

Authors: Yue Yu, Ren-Qi Yao, Yu-Feng Zhang, Su-Yu Wang, Wang Xi, Jun-Nan Wang, Xiao-Yi Huang, Yong-Ming Yao and Zhi-Nong Wang

Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study

Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid over...

Authors: Mei-Ping Wang, Li Jiang, Bo Zhu, Bin Du, Wen Li, Yan He and Xiu-Ming Xi

Meta-analysis with zero-event studies: a comparative study with application to COVID-19 data

Meta-analysis is a statistical method to synthesize evidence from a number of independent studies, including those from clinical studies with binary outcomes. In practice, when there are zero events in one or ...

Authors: Jia-Jin Wei, En-Xuan Lin, Jian-Dong Shi, Ke Yang, Zong-Liang Hu, Xian-Tao Zeng and Tie-Jun Tong

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we review...

Authors: Jian-Hua Cheng, Ding Nie, Bin Li, Song-Bai Gui, Chu-Zhong Li, Ya-Zhuo Zhang, Luigi Maria Cavallo and Peng Zhao

RIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI model

Acute kidney injury (AKI) is the main life-threatening complication of crush syndrome (CS), and myoglobin is accepted as the main pathogenic factor. The pattern recognition receptor retinoicacid-inducible gene...

Authors: Peng-Tao Wang, Ning Li, Xin-Yue Wang, Jia-Le Chen, Chen-Hao Geng, Zi-Quan Liu, Hao-Jun Fan, Qi Lv, Shi-Ke Hou and Yan-Hua Gong

Bioelectrical impedance analysis-guided fluid management promotes primary fascial closure after open abdomen: a randomized controlled trial

Fluid overload (FO) after resuscitation is frequent and contributes to adverse outcomes among postinjury open abdomen (OA) patients. Bioelectrical impedance analysis (BIA) is a promising tool for monitoring fl...

Authors: Kai Wang, Shi-Long Sun, Xin-Yu Wang, Cheng-Nan Chu, Ze-Hua Duan, Chao Yang, Bao-Chen Liu, Wei-Wei Ding, Wei-Qin Li and Jie-Shou Li

Hydration status, body composition, and anxiety status in aeronautical military personnel from Spain: a cross-sectional study

An adequate hydration status is critical to ensure efficiency during mental and physical activities. Our goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine...

Authors: Alejandra Carretero-Krug, Natalia Úbeda, Carlos Velasco, Juan Medina-Font, Trinidad Trujillo Laguna, Gregorio Varela-Moreiras and Ana Montero

Comparative study on the antituberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiaoHe extract and JieHeWan

The traditional Chinese medicine NiuBeiXiaoHe (NBXH) extract and Chinese medicine preparation JieHeWan (JHW) exhibit anti-tuberculosis effects. The anti- tuberculosis effect of NBXH was compared with that of J...

Authors: Li-Yao Duan, Yan Liang, Wen-Ping Gong, Yong Xue, Jie Mi, Jie Wang, Lan Wang, Zai-Xing Jia, Hong Lei, Yu-Mei Liang, Jun Liu, Yue Zheng and Xue-Qiong Wu

Intelligent prediction of RBC demand in trauma patients using decision tree methods

The vital signs of trauma patients are complex and changeable, and the prediction of blood transfusion demand mainly depends on doctors’ experience and trauma scoring system; therefore, it cannot be accurately...

Authors: Yan-Nan Feng, Zhen-Hua Xu, Jun-Ting Liu, Xiao-Lin Sun, De-Qing Wang and Yang Yu

Preferences for pre-exposure prophylaxis among U.S. military men who have sex with men: results of an adaptive choice based conjoint analysis study

Pre-exposure prophylaxis (PrEP) prevents human immunodeficiency virus (HIV) infection, but its use remains low among U.S. military men who have sex with men (MSM), likely due to mis-matching with personal pref...

Authors: José I. Gutierrez, Alex Dubov, Frederick L. Altice and David Vlahov

Predictive modelling for COVID-19 outbreak control: lessons from the navy cluster in Sri Lanka

In response to an outbreak of coronavirus disease 2019 (COVID-19) within a cluster of Navy personnel in Sri Lanka commencing from 22nd April 2020, an aggressive outbreak management program was launched by the ...

Authors: N. W. A. N. Y. Wijesekara, Nayomi Herath, K. A. L. C. Kodituwakku, H. D. B. Herath, Samitha Ginige, Thilanga Ruwanpathirana, Manjula Kariyawasam, Sudath Samaraweera, Anuruddha Herath, Senarupa Jayawardena and Deepa Gamge

Simulated aeromedical evacuation exacerbates burn induced lung injury: targeting mitochondrial DNA for reversal

Aeromedical evacuation of patients with burn trauma is an important transport method in times of peace and war, during which patients are exposed to prolonged periods of hypobaric hypoxia; however, the effects...

Authors: Meng-Jing Xiao, Xiao-Fang Zou, Bin Li, Bao-Long Li, Shi-Jian Wu and Bo Zhang

Urinary bladder cancer as a late sequela of traumatic spinal cord injury

Traumatic spinal cord injury (SCI) is also a combat-related injury that is increasing in modern warfare. The aim of this work is to inform medical experts regarding the different course of bladder cancer in ab...

Authors: Ralf Böthig, Christian Tiburtius, Wolfgang Schöps, Michael Zellner, Oliver Balzer, Birgitt Kowald, Sven Hirschfeld, Roland Thietje, Aki Pietsch, Ines Kurze, Martin Forchert, Thura Kadhum and Klaus Golka

Research progress in the effects of terahertz waves on biomacromolecules

With the rapid development of terahertz technologies, basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomac...

Authors: Liu Sun, Li Zhao and Rui-Yun Peng

Hemopneumothorax detection through the process of artificial evolution - a feasibility study

Tension pneumothorax is one of the leading causes of preventable death on the battlefield. Current prehospital diagnosis relies on a subjective clinical impression complemented by a manual thoracic and respira...

Authors: Adir Sommer, Noy Mark, Gavriel D. Kohlberg, Rafi Gerasi, Linn Wagnert Avraham, Ruth Fan-Marko, Arik Eisenkraft and Dean Nachman

Correction to: Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Meng-Meng Yang, Lu Wang, Yu Zhang, Rui Yuan, Yan Zhao, Jie Hu, Fei-Hu Zhou and Hong-Jun Kang

Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy

Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhag...

Authors: Jing-Chun Song, Li-Kun Yang, Wei Zhao, Feng Zhu, Gang Wang, Yao-Peng Chen and Wei-Qin Li

Correction to: Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

An amendment to this paper has been published and can be accessed via the original article.

Authors: An-Dong Zhao, Hua Qin, Meng-Li Sun, Kui Ma and Xiao-Bing Fu

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Studies have revealed the protective effect of DL-3-n-butylphthalide (NBP) against diseases associated with ischemic hypoxia. However, the role of NBP in animals with hypobaric hypoxia has not been elucidated....

Authors: Gang Xu, Yi-Kun Shi, Bin-Da Sun, Lu Liu, Guo-Ji E., Shu He, Jian-Yang Zhang, Bao Liu, Qiu Hu, Jian Chen, Yu-Qi Gao and Er-Long Zhang