Articles

Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019

The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...

Authors: Hao Zi, Shao-Hua He, Xie-Yuan Leng, Xiao-Feng Xu, Qiao Huang, Hong Weng, Cong Zhu, Lu-Yao Li, Jia-Min Gu, Xu-Hui Li, Dao-Jing Ming, Xiao-Dong Li, Shuai Yuan, Xing-Huan Wang, Da-Lin He and Xian-Tao Zeng

Regional trauma system development in Shenzhen, China: an 8-year journey

Authors: Gui-Xi Zhang, Gilberto Ka Kit Leung, Chung Mau Lo, Richard Kwong-Yin Lo, John Wong, Ronald V. Maier, Eileen M. Bulger, Joe King Man Fan and Xiao-Bing Fu

Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia

Administration of propofol, an intravenous anesthetic with antioxidant property, immediately at the onset of post-ischemic reperfusion (propofol postconditioning, P-PostC) has been shown to confer cardioprotec...

Authors: Rong-Hui Han, He-Meng Huang, Hong Han, Hao Chen, Fei Zeng, Xiang Xie, Dan-Yong Liu, Yin Cai, Liang-Qing Zhang, Xin Liu, Zheng-Yuan Xia and Jing Tang

The roles of exosomal immune checkpoint proteins in tumors

Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However, most patients develop adaptive resistance to this therapy. The latest evidence demonstrates ...

Authors: Cheng Xing, Heng Li, Rui-Juan Li, Le Yin, Hui-Fang Zhang, Zi-Neng Huang, Zhao Cheng, Ji Li, Zhi-Hua Wang and Hong-Ling Peng

Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China

Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whet...

Authors: Yi Wu, Xian-Hui Wang, Xi-Hua Li, Li-Yuan Song, Shi-Long Yu, Zhi-Cheng Fang, Yu-Quan Liu, Le-Yong Yuan, Chun-Yan Peng, Shen-Yi Zhang, Wang Cheng, Hong-Chao Ma, Li-Feng Wang, Jun-Ming Tang, Yun-Fu Wang and Fu-Yun Ji

Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeli...

Authors: Xi-Yao Chen, Yang Jiao and Fu-Yang Zhang

Dementia in military and veteran populations: a review of risk factors—traumatic brain injury, post-traumatic stress disorder, deployment, and sleep

The military population face a unique set of risk factors that may increase the risk of being diagnosed with dementia. Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) have a higher preva...

Authors: Zara Raza, Syeda F. Hussain, Suzanne Ftouni, Gershon Spitz, Nick Caplin, Russell G. Foster and Renata S. M. Gomes

Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Hea...

Authors: Biao Xu, Bo Tu, Fang Chu, Mohamed Jalloh, Jin-Song Mu, Jun-Jie Zheng and Wei-Wei Chen

Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers

Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although periodontitis and genitourinary cancers are two totally distinct types of disorders, epidemiological and clinical studi...

Authors: Shuai Yuan, Cheng Fang, Wei-Dong Leng, Lan Wu, Bing-Hui Li, Xing-Huan Wang, Hailiang Hu and Xian-Tao Zeng

A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China

To determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019 (COVID-19) patients in China. A cross-sectional study was performed in Wuhan from April 3, 2020...

Authors: Jian-Hui Li, Yi Sun, Mei-Rong Li, Hu Yuan, Chang-Liang Yang, Cheng-Cheng Huang, Feng-Jie Zhou, Rui-Yao Chen, Lei-Bo Zhang, Ning Yu, Qiong Liu, Jing-Jing He, Xue-Jun Zhou, Xiao-Bing Fu and Shi-Ming Yang

Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review

By its nature, Gulf war illness (GWI) is multisymptomatic and affects several organ systems in the body. Along with other symptoms, veterans who suffer from GWI commonly report chronic gastrointestinal issues ...

Authors: Diana A. Kimono

Antimicrobial peptides: mechanism of action, activity and clinical potential

The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicro...

Authors: Qi-Yu Zhang, Zhi-Bin Yan, Yue-Ming Meng, Xiang-Yu Hong, Gang Shao, Jun-Jie Ma, Xu-Rui Cheng, Jun Liu, Jian Kang and Cai-Yun Fu

Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelia...

Authors: Duo-Meng Yang, Ting-Ting Geng, Andrew G. Harrison and Peng-Hua Wang

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice

SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and ...

Authors: Natalie Yan-Lin Pang, Alexander Shao-Rong Pang, Vincent T. Chow and De-Yun Wang

Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls

Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.

Authors: Beatrice Alexandra Golomb, Sridevi Devaraj, Alexis K. Messner, Hayley Jean Koslik, Jun Hee Han and Barnabas Yik

Advances in single-cell sequencing: insights from organ transplantation

Single-cell RNA sequencing (scRNA-seq) is a comprehensive technical tool to analyze intracellular and intercellular interaction data by whole transcriptional profile analysis. Here, we describe the application...

Authors: Ying Wang, Jian-Ye Wang, Angelika Schnieke and Konrad Fischer

Data mining in clinical big data: the frequently used databases, steps, and methodological models

Many high quality studies have emerged from public databases, such as Surveillance, Epidemiology, and End Results (SEER), National Health and Nutrition Examination Survey (NHANES), The Cancer Genome Atlas (TCG...

Authors: Wen-Tao Wu, Yuan-Jie Li, Ao-Zi Feng, Li Li, Tao Huang, An-Ding Xu and Jun Lyu

Chronotype and self-reported sleep, alertness, and mental health in U.S. sailors

Service members are at risk for sleep and psychological conditions affecting their readiness. Chronotype (“morningness” or “eveningness”) is strongly associated with sleep, health and performance. The objectiv...

Authors: Elizabeth M. Harrison, Alexandra P. Easterling, Emily A. Schmied, Suzanne L. Hurtado and Gena L. Glickman

Traumatic brain injury and sight loss in military and veteran populations– a review

War and combat exposure pose great risks to the vision system. More recently, vision related deficiencies and impairments have become common with the increased use of powerful explosive devices and the subsequ...

Authors: Syeda F. Hussain, Zara Raza, Andrew T. G. Cash, Thomas Zampieri, Robert A. Mazzoli, Randy H. Kardon and Renata S. M. Gomes

Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study

The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure (AHF) who do not have hypoxemia. The aim of this study was to investigate the association between oxygen ther...

Authors: Yue Yu, Ren-Qi Yao, Yu-Feng Zhang, Su-Yu Wang, Wang Xi, Jun-Nan Wang, Xiao-Yi Huang, Yong-Ming Yao and Zhi-Nong Wang

Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study

Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid over...

Authors: Mei-Ping Wang, Li Jiang, Bo Zhu, Bin Du, Wen Li, Yan He and Xiu-Ming Xi

Meta-analysis with zero-event studies: a comparative study with application to COVID-19 data

Meta-analysis is a statistical method to synthesize evidence from a number of independent studies, including those from clinical studies with binary outcomes. In practice, when there are zero events in one or ...

Authors: Jia-Jin Wei, En-Xuan Lin, Jian-Dong Shi, Ke Yang, Zong-Liang Hu, Xian-Tao Zeng and Tie-Jun Tong

Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we review...

Authors: Jian-Hua Cheng, Ding Nie, Bin Li, Song-Bai Gui, Chu-Zhong Li, Ya-Zhuo Zhang, Luigi Maria Cavallo and Peng Zhao

RIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI model

Acute kidney injury (AKI) is the main life-threatening complication of crush syndrome (CS), and myoglobin is accepted as the main pathogenic factor. The pattern recognition receptor retinoicacid-inducible gene...

Authors: Peng-Tao Wang, Ning Li, Xin-Yue Wang, Jia-Le Chen, Chen-Hao Geng, Zi-Quan Liu, Hao-Jun Fan, Qi Lv, Shi-Ke Hou and Yan-Hua Gong

Bioelectrical impedance analysis-guided fluid management promotes primary fascial closure after open abdomen: a randomized controlled trial

Fluid overload (FO) after resuscitation is frequent and contributes to adverse outcomes among postinjury open abdomen (OA) patients. Bioelectrical impedance analysis (BIA) is a promising tool for monitoring fl...

Authors: Kai Wang, Shi-Long Sun, Xin-Yu Wang, Cheng-Nan Chu, Ze-Hua Duan, Chao Yang, Bao-Chen Liu, Wei-Wei Ding, Wei-Qin Li and Jie-Shou Li

Hydration status, body composition, and anxiety status in aeronautical military personnel from Spain: a cross-sectional study

An adequate hydration status is critical to ensure efficiency during mental and physical activities. Our goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine...

Authors: Alejandra Carretero-Krug, Natalia Úbeda, Carlos Velasco, Juan Medina-Font, Trinidad Trujillo Laguna, Gregorio Varela-Moreiras and Ana Montero

Comparative study on the antituberculous effect and mechanism of the traditional Chinese medicines NiuBeiXiaoHe extract and JieHeWan

The traditional Chinese medicine NiuBeiXiaoHe (NBXH) extract and Chinese medicine preparation JieHeWan (JHW) exhibit anti-tuberculosis effects. The anti- tuberculosis effect of NBXH was compared with that of J...

Authors: Li-Yao Duan, Yan Liang, Wen-Ping Gong, Yong Xue, Jie Mi, Jie Wang, Lan Wang, Zai-Xing Jia, Hong Lei, Yu-Mei Liang, Jun Liu, Yue Zheng and Xue-Qiong Wu

Intelligent prediction of RBC demand in trauma patients using decision tree methods

The vital signs of trauma patients are complex and changeable, and the prediction of blood transfusion demand mainly depends on doctors’ experience and trauma scoring system; therefore, it cannot be accurately...

Authors: Yan-Nan Feng, Zhen-Hua Xu, Jun-Ting Liu, Xiao-Lin Sun, De-Qing Wang and Yang Yu

Preferences for pre-exposure prophylaxis among U.S. military men who have sex with men: results of an adaptive choice based conjoint analysis study

Pre-exposure prophylaxis (PrEP) prevents human immunodeficiency virus (HIV) infection, but its use remains low among U.S. military men who have sex with men (MSM), likely due to mis-matching with personal pref...

Authors: José I. Gutierrez, Alex Dubov, Frederick L. Altice and David Vlahov

Predictive modelling for COVID-19 outbreak control: lessons from the navy cluster in Sri Lanka

In response to an outbreak of coronavirus disease 2019 (COVID-19) within a cluster of Navy personnel in Sri Lanka commencing from 22nd April 2020, an aggressive outbreak management program was launched by the ...

Authors: N. W. A. N. Y. Wijesekara, Nayomi Herath, K. A. L. C. Kodituwakku, H. D. B. Herath, Samitha Ginige, Thilanga Ruwanpathirana, Manjula Kariyawasam, Sudath Samaraweera, Anuruddha Herath, Senarupa Jayawardena and Deepa Gamge

Simulated aeromedical evacuation exacerbates burn induced lung injury: targeting mitochondrial DNA for reversal

Aeromedical evacuation of patients with burn trauma is an important transport method in times of peace and war, during which patients are exposed to prolonged periods of hypobaric hypoxia; however, the effects...

Authors: Meng-Jing Xiao, Xiao-Fang Zou, Bin Li, Bao-Long Li, Shi-Jian Wu and Bo Zhang

Urinary bladder cancer as a late sequela of traumatic spinal cord injury

Traumatic spinal cord injury (SCI) is also a combat-related injury that is increasing in modern warfare. The aim of this work is to inform medical experts regarding the different course of bladder cancer in ab...

Authors: Ralf Böthig, Christian Tiburtius, Wolfgang Schöps, Michael Zellner, Oliver Balzer, Birgitt Kowald, Sven Hirschfeld, Roland Thietje, Aki Pietsch, Ines Kurze, Martin Forchert, Thura Kadhum and Klaus Golka

Research progress in the effects of terahertz waves on biomacromolecules

With the rapid development of terahertz technologies, basic research and applications of terahertz waves in biomedicine have attracted increasing attention. The rotation and vibrational energy levels of biomac...

Authors: Liu Sun, Li Zhao and Rui-Yun Peng

Hemopneumothorax detection through the process of artificial evolution - a feasibility study

Tension pneumothorax is one of the leading causes of preventable death on the battlefield. Current prehospital diagnosis relies on a subjective clinical impression complemented by a manual thoracic and respira...

Authors: Adir Sommer, Noy Mark, Gavriel D. Kohlberg, Rafi Gerasi, Linn Wagnert Avraham, Ruth Fan-Marko, Arik Eisenkraft and Dean Nachman

Correction to: Establishment and effectiveness evaluation of a scoring system for exertional heat stroke by retrospective analysis

An amendment to this paper has been published and can be accessed via the original article.

Authors: Meng-Meng Yang, Lu Wang, Yu Zhang, Rui Yuan, Yan Zhao, Jie Hu, Fei-Hu Zhou and Hong-Jun Kang

Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy

Trauma-induced coagulopathy (TIC) is caused by post-traumatic tissue injury and manifests as hypercoagulability that leads to thromboembolism or hypocoagulability that leads to uncontrollable massive hemorrhag...

Authors: Jing-Chun Song, Li-Kun Yang, Wei Zhao, Feng Zhu, Gang Wang, Yao-Peng Chen and Wei-Qin Li

Correction to: Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules

An amendment to this paper has been published and can be accessed via the original article.

Authors: An-Dong Zhao, Hua Qin, Meng-Li Sun, Kui Ma and Xiao-Bing Fu

DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia

Studies have revealed the protective effect of DL-3-n-butylphthalide (NBP) against diseases associated with ischemic hypoxia. However, the role of NBP in animals with hypobaric hypoxia has not been elucidated....

Authors: Gang Xu, Yi-Kun Shi, Bin-Da Sun, Lu Liu, Guo-Ji E., Shu He, Jian-Yang Zhang, Bao Liu, Qiu Hu, Jian Chen, Yu-Qi Gao and Er-Long Zhang

Early stage nonclinical pulmonary disorder in COVID-19 may present asymptomatic and fuel the contagion

Evidence shows that pulmonary problems in coronavirus disease 2019 (COVID-19) may set off from vascular injury that progresses to physiological disturbances through a compromised gas exchange, following an inf...

Authors: Kamoru Ademola Adedokun

Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study

To develop an effective model of predicting fatal outcomes in the severe coronavirus disease 2019 (COVID-19) patients.

Authors: Yun Yang, Xiao-Fei Zhu, Jian Huang, Cui Chen, Yang Zheng, Wei He, Ling-Hao Zhao, Qian Gao, Xuan-Xuan Huang, Li-Juan Fu, Yu Zhang, Yan-Qin Chang, Huo-Jun Zhang and Zhi-Jie Lu

Military medical research on internal diseases in modern warfare: new concepts, demands, challenges, and opportunities

Battlefield internal medicine aims at the treatment of combatants and noncombatants with various internal diseases on the battlefield. The military medical research on battlefield internal diseases focuses on ...

Authors: Guang-Dong Liu, Nan Wang, Hai-Ming Wang, Xin Li, Jun-Jie Shao, Zi-Fan Liu, Min Jiang, Lin Wang, Zi-Kai Wang, Meng Li, Xue-Ying Cao, Jiang Wang, Ran Zhang and Yun-Dai Chen

Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection

Invasive Trichosporon asahii (T. asahii) infection frequently occurs with a high mortality in immunodeficient hosts, but the pathogenesis of T. asahii infection remains elusive. Circular RNAs (circRNAs) are a typ...

Authors: Ming-Wang Zhang, Zhi-Hong Zhu, Zhi-Kuan Xia, Xin Yang, Wan-Ting Luo, Jun-Hong Ao and Rong-Ya Yang

Recombinant human epidermal growth factor combined with vacuum sealing drainage for wound healing in Bama pigs

Vacuum sealing drainage (VSD) and epidermal growth factor (EGF) both play an important role in the treatment of wounds. This study aims to explore the effects of the combination of VSD and EGF on wound healing...

Authors: Shuai Wei, Wei Wang, Li Li, Hao-Ye Meng, Chun-Zhen Feng, Yu-Ying Dong, Xi-Chi Fang, Qi-Qiang Dong, Wen Jiang, Hai-Li Xin, Zhan-Zhen Li and Xin Wang

Benefits of early ambulation within 24 h after total knee arthroplasty: a multicenter retrospective cohort study in China

Postoperative care has been evolving since the concept of enhanced recovery after surgery (ERAS) was introduced in China. This study aimed to evaluate the effects of early ambulation within 24 h after unilater...

Authors: Yi-Ting Lei, Jin-Wei Xie, Qiang Huang, Wei Huang and Fu-Xing Pei

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Toll-like receptor 5 (TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic diseases. However, the role of TLR5 in e...

Authors: Wen Zhang, Lei Wang, Xue-Hua Sun, Xian Liu, Yang Xiao, Jie Zhang, Ting Wang, Hui Chen, Yi-Qun Zhan, Miao Yu, Chang-Hui Ge, Chang-Yan Li, Guang-Ming Ren, Rong-Hua Yin and Xiao-Ming Yang

The effects of 12 weeks of functional strength training on muscle strength, volume and activity upon exposure to elevated G_z forces in high-performance aircraft personnel

Technological advancements in modern military and acrobatic jet planes have resulted in extraordinary psychophysiological loads being exerted upon flying personnel, including inducing neck and back pain. The p...

Authors: Monika Rausch, Frank Weber, Sven Kühn, Carla Ledderhos, Christoph Zinner and Billy Sperlich

Establishment of injury models in studies of biological effects induced by microwave radiation

Microwave radiation has been widely used in various fields, such as communication, industry, medical treatment, and military applications. Microwave radiation may cause injuries to both the structures and func...

Authors: Yun-Fei Lai, Hao-Yu Wang and Rui-Yun Peng

Association between medical resources and the proportion of oldest-old in the Chinese population

The potential association between medical resources and the proportion of oldest-old (90 years of age and above) in the Chinese population was examined, and we found that the higher proportion of oldest-old wa...

Authors: Chao Tan, Cai-Zhi Tang, Xing-Shu Chen and Yong-Jun Luo

Comparison of acute pneumonia caused by SARS-COV-2 and other respiratory viruses in children: a retrospective multi-center cohort study during COVID-19 outbreak

Until January 18, 2021, coronavirus disease-2019 (COVID-19) has infected more than 93 million individuals and has caused a certain degree of panic. Viral pneumonia caused by common viruses such as respiratory ...

Authors: Guang-Li Ren, Xian-Feng Wang, Jun Xu, Jun Li, Qiong Meng, Guo-Qiang Xie, Bo Huang, Wei-Chun Zhu, Jing Lin, Cheng-He Tang, Sheng Ye, Zhuo Li, Jie Zhu, Zhen Tang, Ming-Xin Ma, Cong Xie…

Correction to: Combating an invisible enemy: the American military response to global pandemics

An amendment to this paper has been published and can be accessed via the original article.

Authors: Lauren K. Dutton, Peter C. Rhee, Alexander Y. Shin, Richard J. Ehrlichman and Richard J. Shemin