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Citation: Military Medical Research 2023 10:57
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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liv...
Citation: Military Medical Research 2023 10:56 -
Cognitive function among military veterans with STEM occupations
Citation: Military Medical Research 2023 10:55 -
Insights into the underlying pathogenesis and therapeutic potential of endoplasmic reticulum stress in degenerative musculoskeletal diseases
Degenerative musculoskeletal diseases are structural and functional failures of the musculoskeletal system, including osteoarthritis, osteoporosis, intervertebral disc degeneration (IVDD), and sarcopenia. As t...
Citation: Military Medical Research 2023 10:54 -
Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is associated with disordered lipid and iron metabolism. Our previous study has substantiated the pivotal role of Caveolin-1 (Cav-1) in protecting hepatocytes and media...
Citation: Military Medical Research 2023 10:53 -
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer
Advances in chimeric antigen receptor (CAR)-T cell therapy have significantly improved clinical outcomes of patients with relapsed or refractory hematologic malignancies. However, progress is still hindered as...
Citation: Military Medical Research 2023 10:52 -
The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives
Regulation of gut microbiota and its impact on human health is the theme of intensive research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating as the global population age...
Citation: Military Medical Research 2023 10:51 -
How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology
In the United States (US), the Surveillance, Epidemiology, and End Results (SEER) program is the only comprehensive source of population-based information that includes stage of cancer at the time of diagnosis...
Citation: Military Medical Research 2023 10:50 -
Regulatory T cells in skin regeneration and wound healing
As the body’s integumentary system, the skin is vulnerable to injuries. The subsequent wound healing processes aim to restore dermal and epidermal integrity and functionality. To this end, multiple tissue-resi...
Citation: Military Medical Research 2023 10:49 -
Elucidating regulatory processes of intense physical activity by multi-omics analysis
Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, mili...
Citation: Military Medical Research 2023 10:48 -
White-light-induced synthesis of injectable alginate-based composite hydrogels for rapid hemostasis
Citation: Military Medical Research 2023 10:47 -
Multifaceted functions of Drp1 in hypoxia/ischemia-induced mitochondrial quality imbalance: from regulatory mechanism to targeted therapeutic strategy
Hypoxic-ischemic injury is a common pathological dysfunction in clinical settings. Mitochondria are sensitive organelles that are readily damaged following ischemia and hypoxia. Dynamin-related protein 1 (Drp1...
Citation: Military Medical Research 2023 10:46 -
Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese and Western medicine
Integrated traditional Chinese medicine (TCM) and Western medicine (WM) is a new medical science grounded in the knowledge bases of both TCM and WM, which then forms a unique modern medical system in China. In...
Citation: Military Medical Research 2023 10:45 -
Deep learning-based lung sound analysis for intelligent stethoscope
Auscultation is crucial for the diagnosis of respiratory system diseases. However, traditional stethoscopes have inherent limitations, such as inter-listener variability and subjectivity, and they cannot recor...
Citation: Military Medical Research 2023 10:44 -
Enhancing the clinical relevance of haemorrhage prediction models in trauma
Citation: Military Medical Research 2023 10:43 -
RARRES2’s impact on lipid metabolism in triple-negative breast cancer: a pathway to brain metastasis
Citation: Military Medical Research 2023 10:42 -
Heat exposure and hospitalizations for chronic kidney disease in China: a nationwide time series study in 261 major Chinese cities
Climate change profoundly shapes the population health at the global scale. However, there was still insufficient and inconsistent evidence for the association between heat exposure and chronic kidney disease ...
Citation: Military Medical Research 2023 10:41 -
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabeti...
Citation: Military Medical Research 2023 10:37 -
Bioengineered skin organoids: from development to applications
Significant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional models that mimic human skin, these organoids have evolved into c...
Citation: Military Medical Research 2023 10:40 -
Physical exercise reverses immuno-cold tumor microenvironment via inhibiting SQLE in non-small cell lung cancer
Citation: Military Medical Research 2023 10:39 -
Spatial transcriptomics: recent developments and insights in respiratory research
The respiratory system’s complex cellular heterogeneity presents unique challenges to researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) have provided insights i...
Citation: Military Medical Research 2023 10:38 -
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: roles, opportunities and challenges
Skin wounds are characterized by injury to the skin due to trauma, tearing, cuts, or contusions. As such injuries are common to all human groups, they may at times represent a serious socioeconomic burden. Cur...
Citation: Military Medical Research 2023 10:36 -
The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine
Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots ...
Citation: Military Medical Research 2023 10:35 -
RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer
Triple negative breast cancer (TNBC), the most aggressive subtype of breast cancer, is characterized by a high incidence of brain metastasis (BrM) and a poor prognosis. As the most lethal form of breast cancer...
Citation: Military Medical Research 2023 10:34 -
China stroke surveillance report 2021
Since 2015, stroke has become the leading cause of death and disability in China, posing a significant threat to the health of its citizens as a major chronic non-communicable disease. According to the China S...
Citation: Military Medical Research 2023 10:33 -
Targeting miRNA by CRISPR/Cas in cancer: advantages and challenges
Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last decade. In th...
Citation: Military Medical Research 2023 10:32 -
Activatable fluorescent probes for imaging and diagnosis of rheumatoid arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adve...
Citation: Military Medical Research 2023 10:31 -
Correction to: Bioengineered materials with selective antimicrobial toxicity in biomedicine
Citation: Military Medical Research 2023 10:30 -
What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments?
The present study aimed to explore the potential of artificial intelligence (AI) methodology based on magnetic resonance (MR) images to aid in the management of prostate cancer (PCa). To this end, we reviewed ...
Citation: Military Medical Research 2023 10:29 -
Advancing our understanding of monocyte HLA-DR, S100A9, and the potential for individualized therapies in sepsis
Citation: Military Medical Research 2023 10:28 -
Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function
Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise ind...
Citation: Military Medical Research 2023 10:27 -
A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological mechanisms directed t...
Citation: Military Medical Research 2023 10:26 -
Aspartoacylase suppresses prostate cancer progression by blocking LYN activation
Globally, despite prostate cancer (PCa) representing second most prevalent malignancy in male, the precise molecular mechanisms implicated in its pathogenesis remain unclear. Consequently, elucidating the key ...
Citation: Military Medical Research 2023 10:25 -
Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia: randomized trials and multiomics analysis
Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly variable and difficult to predict due to the lac...
Citation: Military Medical Research 2023 10:24 -
Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus
Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal c...
Citation: Military Medical Research 2023 10:23 -
Artificial intelligence-driven radiomics study in cancer: the role of feature engineering and modeling
Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’ anatomy. However, the interpretation of medical images can be highly subjective and dependent on the ex...
Citation: Military Medical Research 2023 10:22 -
Elimination of methicillin-resistant Staphylococcus aureus biofilms on titanium implants via photothermally-triggered nitric oxide and immunotherapy for enhanced osseointegration
Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium (Ti) implants. There is a need to explo...
Citation: Military Medical Research 2023 10:21 -
Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
Immune checkpoint blockade (ICB) therapy for cancer has achieved great success both in clinical results and on the market. At the same time, success drives more attention from scientists to improve it. However...
Citation: Military Medical Research 2023 10:20 -
Bioengineered exosomal-membrane-camouflaged abiotic nanocarriers: neurodegenerative diseases, tissue engineering and regenerative medicine
A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nano...
Citation: Military Medical Research 2023 10:19 -
Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Heart injury such as myocardial infarction leads to cardiomyocyte loss, fibrotic tissue deposition, and scar formation. These changes reduce cardiac contractility, resulting in heart failure, which causes a hu...
Citation: Military Medical Research 2023 10:18 -
In situ forming injectable MSC-loaded GelMA hydrogels combined with PD for vascularized sweat gland regeneration
Citation: Military Medical Research 2023 10:17 -
Biomimetic natural biomaterials for tissue engineering and regenerative medicine: new biosynthesis methods, recent advances, and emerging applications
Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic s...
Citation: Military Medical Research 2023 10:16 -
Adhesive cryogel particles for bridging confined and irregular tissue defects
Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging. Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies, making...
Citation: Military Medical Research 2023 10:15 -
Investigation of the cell composition and gene expression in the delayed-type hypersensitivity tuberculin skin test
Citation: Military Medical Research 2023 10:14 -
Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function: implication of miRNAs and microvesicles
Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis. We hypothesized that pericytes, a group of pluripotent cells that maintain vascular integrity ...
Citation: Military Medical Research 2023 10:13 -
Recent advances in CRISPR-based genome editing technology and its applications in cardiovascular research
The rapid development of genome editing technology has brought major breakthroughs in the fields of life science and medicine. In recent years, the clustered regularly interspaced short palindromic repeats (CR...
Citation: Military Medical Research 2023 10:12 -
Chemical exposures and suspected impact on Gulf War Veterans
Gulf War Illness (GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War (1990–1991). There are several hypothesized factors believed to contribute to GWI, including (but...
Citation: Military Medical Research 2023 10:11 -
Applications and prospects of cryo-EM in drug discovery
Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology ha...
Citation: Military Medical Research 2023 10:10 -
Ionizable drug delivery systems for efficient and selective gene therapy
Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the nucleic acid formulations to the market is the safe and effe...
Citation: Military Medical Research 2023 10:9 -
Bioengineered materials with selective antimicrobial toxicity in biomedicine
Fungi and bacteria afflict humans with innumerous pathogen-related infections and ailments. Most of the commonly employed microbicidal agents target commensal and pathogenic microorganisms without discriminati...
Citation: Military Medical Research 2023 10:8
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- ISSN: 2054-9369 (electronic)