Articles
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Citation: Military Medical Research 2024 11:43
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Gut microbiota helps identify clinical subtypes of Parkinson’s disease
Citation: Military Medical Research 2024 11:42 -
PANX1-mediated ATP release confers FAM3A’s suppression effects on hepatic gluconeogenesis and lipogenesis
Extracellular adenosine triphosphate (ATP) is an important signal molecule. In previous studies, intensive research had revealed the crucial roles of family with sequence similarity 3 member A (FAM3A) in contr...
Citation: Military Medical Research 2024 11:41 -
Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family
Fibroblast growth factor (FGF) signaling encompasses a multitude of functions, including regulation of cell proliferation, differentiation, morphogenesis, and patterning. FGFs and their receptors (FGFR) are cr...
Citation: Military Medical Research 2024 11:40 -
Novel radiopaque ethanol injection: physicochemical properties, animal experiments, and clinical application in vascular malformations
Despite the efficacy of absolute ethanol (EtOH), its radiolucency introduces several risks in interventional therapy for treating vascular malformations. This study aims to develop a novel radiopaque ethanol i...
Citation: Military Medical Research 2024 11:39 -
Digital in-line holographic microscopy for label-free identification and tracking of biological cells
Digital in-line holographic microscopy (DIHM) is a non-invasive, real-time, label-free technique that captures three-dimensional (3D) positional, orientational, and morphological information from digital holog...
Citation: Military Medical Research 2024 11:38 -
Bone-organ axes: bidirectional crosstalk
In addition to its recognized role in providing structural support, bone plays a crucial role in maintaining the functionality and balance of various organs by secreting specific cytokines (also known as osteo...
Citation: Military Medical Research 2024 11:37 -
Genome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
Citation: Military Medical Research 2024 11:36 -
Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) a...
Citation: Military Medical Research 2024 11:35 -
Advances in the isolation, cultivation, and identification of gut microbes
The gut microbiome is closely associated with human health and the development of diseases. Isolating, characterizing, and identifying gut microbes are crucial for research on the gut microbiome and essential ...
Citation: Military Medical Research 2024 11:34 -
Advancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited understanding of the underlying pathological processes at the cellu...
Citation: Military Medical Research 2024 11:33 -
Mitochondrial quality control in human health and disease
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispens...
Citation: Military Medical Research 2024 11:32 -
Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
Citation: Military Medical Research 2024 11:31 -
P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
Benign prostatic hyperplasia (BPH) is the most common disease in elderly men. There is increasing evidence that periodontitis increases the risk of BPH, but the specific mechanism remains unclear. This study a...
Citation: Military Medical Research 2024 11:30 -
Biomaterials science and surface engineering strategies for dental peri-implantitis management
Peri-implantitis is a bacterial infection that causes soft tissue inflammatory lesions and alveolar bone resorption, ultimately resulting in implant failure. Dental implants for clinical use barely have antiba...
Citation: Military Medical Research 2024 11:29 -
D-mannose alleviates intervertebral disc degeneration through glutamine metabolism
Intervertebral disc degeneration (IVDD) is a multifaceted condition characterized by heterogeneity, wherein the balance between catabolism and anabolism in the extracellular matrix of nucleus pulposus (NP) cel...
Citation: Military Medical Research 2024 11:28 -
Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood.
Citation: Military Medical Research 2024 11:27 -
N-terminal pro-brain natriuretic peptide – a significant biomarker of disease development and adverse prognosis in patients with exertional heat stroke
Citation: Military Medical Research 2024 11:26 -
CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations
Citation: Military Medical Research 2024 11:25 -
Exosomal mediators in sepsis and inflammatory organ injury: unraveling the role of exosomes in intercellular crosstalk and organ dysfunction
Sepsis, a severe systemic inflammatory response to infection, remains a leading cause of morbidity and mortality worldwide. Exosomes, as mediators of intercellular communication, play a pivotal role in the pat...
Citation: Military Medical Research 2024 11:24 -
Cellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Chronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring significant human and financial resources. Chronic wounds arise from the complex interplay of und...
Citation: Military Medical Research 2024 11:23 -
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
Liver ischemia/reperfusion (I/R) injury is usually caused by hepatic inflow occlusion during liver surgery, and is frequently observed during war wounds and trauma. Hepatocyte ferroptosis plays a critical role...
Citation: Military Medical Research 2024 11:22 -
The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
In recent years, advancements in single-cell and spatial transcriptomics, which are highly regarded developments in the current era, particularly the emerging integration of single-cell and spatiotemporal tran...
Citation: Military Medical Research 2024 11:21 -
FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury
Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulat...
Citation: Military Medical Research 2024 11:20 -
Immune cells: potential carriers or agents for drug delivery to the central nervous system
Drug delivery systems (DDS) have recently emerged as a promising approach for the unique advantages of drug protection and targeted delivery. However, the access of nanoparticles/drugs to the central nervous s...
Citation: Military Medical Research 2024 11:19 -
Heart-brain axis: low blood pressure during off-pump CABG surgery is associated with postoperative heart failure
Citation: Military Medical Research 2024 11:18 -
Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
Tactile and mechanical pain are crucial to our interaction with the environment, yet the underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) is an evolutionarily conserved protein that is...
Citation: Military Medical Research 2024 11:17 -
Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss
Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease (AD), which is closely related to tau pathology and hippocampal impairment. Due to the heterogeneity of brain neurons, the spec...
Citation: Military Medical Research 2024 11:16 -
Emerging roles of ADP-dependent glucokinase in prostate cancer
Citation: Military Medical Research 2024 11:15 -
CT whole lung radiomic nomogram: a potential biomarker for lung function evaluation and identification of COPD
Computed tomography (CT) plays a great role in characterizing and quantifying changes in lung structure and function of chronic obstructive pulmonary disease (COPD). This study aimed to explore the performance...
Citation: Military Medical Research 2024 11:14 -
Biomaterial-based mechanical regulation facilitates scarless wound healing with functional skin appendage regeneration
Scar formation resulting from burns or severe trauma can significantly compromise the structural integrity of skin and lead to permanent loss of skin appendages, ultimately impairing its normal physiological f...
Citation: Military Medical Research 2024 11:13 -
ADP-dependent glucokinase: the ancient, archaeal key to prostate cancer
Citation: Military Medical Research 2024 11:10 -
Deciphering the molecular interplay and tumorigenesis in hepatocellular carcinoma through insights into FBXL6 and KRASG12D
Citation: Military Medical Research 2024 11:9 -
In situ genetic engineering of host T-cells based on acellular scaffold strategy: a big but also small step for solid tumor immunotherapy
Citation: Military Medical Research 2024 11:12 -
Alleviating mitochondrial dysfunction in diabetic cardiomyopathy through the Adipsin and Irak2 pathways
Citation: Military Medical Research 2024 11:11 -
Nickel’s carcinogenicity: the need of more studies to progress
Citation: Military Medical Research 2024 11:8 -
Antimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most threatening pathogens against which novel antibiotics need to be dev...
Citation: Military Medical Research 2024 11:7 -
Monitoring of urinary iodine concentration in naval pilots: should iodine be supplemented or limited at coastal stations?
Citation: Military Medical Research 2024 11:6 -
Gulf War illness with or without post-traumatic stress disorder: differential symptoms and immune responses
Citation: Military Medical Research 2024 11:5 -
GPR65 as a potential novel therapeutic target for the treatment of hepatic fibrosis
Citation: Military Medical Research 2024 11:4 -
Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
Targeted T-cell therapy has emerged as a promising strategy for the treatment of hematological malignancies. However, its application to solid tumors presents significant challenges due to the limited accessib...
Citation: Military Medical Research 2024 11:3 -
Interleukin-1 receptor associated kinase 2 is a functional downstream regulator of complement factor D that controls mitochondrial fitness in diabetic cardiomyopathy
Citation: Military Medical Research 2024 11:1 -
Disentangling the effects of PTSD from Gulf War Illness in male veterans via a systems-wide analysis of immune cell, cytokine, and symptom measures
One-third of veterans returning from the 1990–1991 Gulf War reported a myriad of symptoms including cognitive dysfunction, skin rashes, musculoskeletal discomfort, and fatigue. This symptom cluster is now refe...
Citation: Military Medical Research 2024 11:2 -
Elevated FBXL6 activates both wild-type KRAS and mutant KRASG12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice
Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box...
Citation: Military Medical Research 2023 10:68 -
The applied principles of EEG analysis methods in neuroscience and clinical neurology
Electroencephalography (EEG) is a non-invasive measurement method for brain activity. Due to its safety, high resolution, and hypersensitivity to dynamic changes in brain neural signals, EEG has aroused much i...
Citation: Military Medical Research 2023 10:67 -
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury
The essential roles of platelets in thrombosis have been well recognized. Unexpectedly, thrombosis is prevalent during thrombocytopenia induced by cytotoxicity of biological, physical and chemical origins, whi...
Citation: Military Medical Research 2023 10:66 -
Pre-hospital application of REBOA for life-threatening hemorrhage
Citation: Military Medical Research 2023 10:65 -
ADP-dependent glucokinase controls metabolic fitness in prostate cancer progression
Cell metabolism plays a pivotal role in tumor progression, and targeting cancer metabolism might effectively kill cancer cells. We aimed to investigate the role of hexokinases in prostate cancer (PCa) and iden...
Citation: Military Medical Research 2023 10:64 -
Adipsin inhibits Irak2 mitochondrial translocation and improves fatty acid β-oxidation to alleviate diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and fatty acids in the myocardium usually results in lipotoxicity, whi...
Citation: Military Medical Research 2023 10:63 -
Targeting NR1D1 in organ injury: challenges and prospects
Nuclear receptor subfamily 1, group D, member 1 (NR1D1, also known as REV-ERBα) belongs to the nuclear receptor (NR) family, and is a heme-binding component of the circadian clock that consolidates circadian o...
Citation: Military Medical Research 2023 10:62
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- ISSN: 2054-9369 (electronic)