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  1. Since 2015, stroke has become the leading cause of death and disability in China, posing a significant threat to the health of its citizens as a major chronic non-communicable disease. According to the China S...

    Authors: Wen-Jun Tu and Long-De Wang
    Citation: Military Medical Research 2023 10:33
  2. Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed biomedical research and provided entirely new models to analyze every aspect of biomedical sciences during the last decade. In th...

    Authors: Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Snur Rasool Abdullah, Hazha Jamal Hidayat, Goran Sedeeq Hama Faraj, Fattma Abodi Ali, Abbas Salihi, Aria Baniahmad, Soudeh Ghafouri-Fard, Milladur Rahman, Mark C. Glassy, Wojciech Branicki and Mohammad Taheri
    Citation: Military Medical Research 2023 10:32
  3. Rheumatoid arthritis (RA) is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability, thus adve...

    Authors: Pan Luo, Fu-Qiang Gao, Wei Sun, Jun-You Li, Cheng Wang, Qing-Yu Zhang, Zhi-Zhuo Li and Peng Xu
    Citation: Military Medical Research 2023 10:31
  4. The present study aimed to explore the potential of artificial intelligence (AI) methodology based on magnetic resonance (MR) images to aid in the management of prostate cancer (PCa). To this end, we reviewed ...

    Authors: Li-Tao Zhao, Zhen-Yu Liu, Wan-Fang Xie, Li-Zhi Shao, Jian Lu, Jie Tian and Jian-Gang Liu
    Citation: Military Medical Research 2023 10:29
  5. Sustained yet intractable immunosuppression is commonly observed in septic patients, resulting in aggravated clinical outcomes. However, due to the substantial heterogeneity within septic patients, precise ind...

    Authors: Ren-Qi Yao, Peng-Yue Zhao, Zhi-Xuan Li, Yu-Yang Liu, Li-Yu Zheng, Yu Duan, Lu Wang, Rong-Li Yang, Hong-Jun Kang, Ji-Wei Hao, Jing-Yan Li, Ning Dong, Yao Wu, Xiao-Hui Du, Feng Zhu, Chao Ren…
    Citation: Military Medical Research 2023 10:27

    The Commentary to this article has been published in Military Medical Research 2023 10:28

  6. Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological mechanisms directed t...

    Authors: Miguel A. Ortega, Oscar Fraile-Martinez, Cielo García-Montero, Sergio Haro, Miguel Ángel Álvarez-Mon, Diego De Leon-Oliva, Ana M. Gomez-Lahoz, Jorge Monserrat, Mar Atienza-Pérez, David Díaz, Elisa Lopez-Dolado and Melchor Álvarez-Mon
    Citation: Military Medical Research 2023 10:26
  7. Globally, despite prostate cancer (PCa) representing second most prevalent malignancy in male, the precise molecular mechanisms implicated in its pathogenesis remain unclear. Consequently, elucidating the key ...

    Authors: Hong Weng, Kang-Ping Xiong, Wang Wang, Kai-Yu Qian, Shuai Yuan, Gang Wang, Fang Yu, Jun Luo, Meng-Xin Lu, Zhong-Hua Yang, Tao Liu, Xing Huang, Hang Zheng and Xing-Huan Wang
    Citation: Military Medical Research 2023 10:25
  8. Choosing the appropriate antipsychotic drug (APD) treatment for patients with schizophrenia (SCZ) can be challenging, as the treatment response to APD is highly variable and difficult to predict due to the lac...

    Authors: Liang-Kun Guo, Yi Su, Yu-Ya-Nan Zhang, Hao Yu, Zhe Lu, Wen-Qiang Li, Yong-Feng Yang, Xiao Xiao, Hao Yan, Tian-Lan Lu, Jun Li, Yun-Dan Liao, Zhe-Wei Kang, Li-Fang Wang, Yue Li, Ming Li…
    Citation: Military Medical Research 2023 10:24
  9. Continuous renal replacement therapy (CRRT) is widely used for treating critically-ill patients in the emergency department in China. Anticoagulant therapy is needed to prevent clotting in the extracorporeal c...

    Authors: Shu-Yuan Liu, Sheng-Yong Xu, Lu Yin, Ting Yang, Kui Jin, Qiu-Bin Zhang, Feng Sun, Ding-Yu Tan, Tian-Yu Xin, Yu-Guo Chen, Xiao-Dong Zhao, Xue-Zhong Yu and Jun Xu
    Citation: Military Medical Research 2023 10:23
  10. Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’ anatomy. However, the interpretation of medical images can be highly subjective and dependent on the ex...

    Authors: Yuan-Peng Zhang, Xin-Yun Zhang, Yu-Ting Cheng, Bing Li, Xin-Zhi Teng, Jiang Zhang, Saikit Lam, Ta Zhou, Zong-Rui Ma, Jia-Bao Sheng, Victor C. W. Tam, Shara W. Y. Lee, Hong Ge and Jing Cai
    Citation: Military Medical Research 2023 10:22
  11. Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack of antimicrobial activity of titanium (Ti) implants. There is a need to explo...

    Authors: Yong-Lin Yu, Jun-Jie Wu, Chuan-Chuan Lin, Xian Qin, Franklin R. Tay, Li Miao, Bai-Long Tao and Yang Jiao
    Citation: Military Medical Research 2023 10:21
  12. A bio-inspired strategy has recently been developed for camouflaging nanocarriers with biomembranes, such as natural cell membranes or subcellular structure-derived membranes. This strategy endows cloaked nano...

    Authors: Daniela Lopes, Joana Lopes, Miguel Pereira-Silva, Diana Peixoto, Navid Rabiee, Francisco Veiga, Omid Moradi, Zhan-Hu Guo, Xiang-Dong Wang, João Conde, Pooyan Makvandi and Ana Cláudia Paiva-Santos
    Citation: Military Medical Research 2023 10:19
  13. Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering (TE) and regenerative medicine. In contrast to conventional biomaterials or synthetic materials, biomimetic s...

    Authors: Shuai Liu, Jiang-Ming Yu, Yan-Chang Gan, Xiao-Zhong Qiu, Zhe-Chen Gao, Huan Wang, Shi-Xuan Chen, Yuan Xiong, Guo-Hui Liu, Si-En Lin, Alec McCarthy, Johnson V. John, Dai-Xu Wei and Hong-Hao Hou
    Citation: Military Medical Research 2023 10:16
  14. Reconstruction of damaged tissues requires both surface hemostasis and tissue bridging. Tissues with damage resulting from physical trauma or surgical treatments may have arbitrary surface topographies, making...

    Authors: Yao-Ting Xue, Ming-Yu Chen, Jia-Sheng Cao, Lei Wang, Jia-Hao Hu, Si-Yang Li, Ji-Liang Shen, Xin-Ge Li, Kai-Hang Zhang, Shu-Qiang Hao, Sarun Juengpanich, Si-Bo Cheng, Tuck-Whye Wong, Xu-Xu Yang, Tie-Feng Li, Xiu-Jun Cai…
    Citation: Military Medical Research 2023 10:15
  15. Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon sepsis. We hypothesized that pericytes, a group of pluripotent cells that maintain vascular integrity ...

    Authors: Zi-Sen Zhang, Yi-Yan Liu, Shuang-Shuang He, Dai-Qin Bao, Hong-Chen Wang, Jie Zhang, Xiao-Yong Peng, Jia-Tao Zang, Yu Zhu, Yue Wu, Qing-Hui Li, Tao Li and Liang-Ming Liu
    Citation: Military Medical Research 2023 10:13
  16. The rapid development of genome editing technology has brought major breakthroughs in the fields of life science and medicine. In recent years, the clustered regularly interspaced short palindromic repeats (CR...

    Authors: Zhen-Hua Li, Jun Wang, Jing-Ping Xu, Jian Wang and Xiao Yang
    Citation: Military Medical Research 2023 10:12
  17. Gulf War Illness (GWI) encompass a spectrum of maladies specific to troops deployed during the Persian Gulf War (1990–1991). There are several hypothesized factors believed to contribute to GWI, including (but...

    Authors: Rami Elhaj and Joseph M. Reynolds
    Citation: Military Medical Research 2023 10:11
  18. Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology ha...

    Authors: Kong-Fu Zhu, Chuang Yuan, Yong-Ming Du, Kai-Lei Sun, Xiao-Kang Zhang, Horst Vogel, Xu-Dong Jia, Yuan-Zhu Gao, Qin-Fen Zhang, Da-Ping Wang and Hua-Wei Zhang
    Citation: Military Medical Research 2023 10:10
  19. Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the nucleic acid formulations to the market is the safe and effe...

    Authors: Yu-Qi Zhang, Ran-Ran Guo, Yong-Hu Chen, Tian-Cheng Li, Wen-Zhen Du, Rong-Wu Xiang, Ji-Bin Guan, Yu-Peng Li, Yuan-Yu Huang, Zhi-Qiang Yu, Yin Cai, Peng Zhang and Gui-Xia Ling
    Citation: Military Medical Research 2023 10:9
  20. Fungi and bacteria afflict humans with innumerous pathogen-related infections and ailments. Most of the commonly employed microbicidal agents target commensal and pathogenic microorganisms without discriminati...

    Authors: Pooyan Makvandi, Hao Song, Cynthia K. Y. Yiu, Rossella Sartorius, Ehsan Nazarzadeh Zare, Navid Rabiee, Wei-Xi Wu, Ana Cláudia Paiva-Santos, Xiang-Dong Wang, Cheng-Zhong Yu and Franklin R. Tay
    Citation: Military Medical Research 2023 10:8

    The Correction to this article has been published in Military Medical Research 2023 10:30

  21. Triclosan [5-chloro-2-(2,4-dichlorophenoxy) phenol, TCS], a common antimicrobial additive in many personal care and health care products, is frequently detected in human blood and urine. Therefore, it has been...

    Authors: Yun-Meng Bai, Fan Yang, Piao Luo, Lu-Lin Xie, Jun-Hui Chen, Yu-Dong Guan, Hong-Chao Zhou, Teng-Fei Xu, Hui-Wen Hao, Bing Chen, Jia-Hui Zhao, Cai-Ling Liang, Ling-Yun Dai, Qing-Shan Geng and Ji-Gang Wang
    Citation: Military Medical Research 2023 10:7
  22. Artificial intelligence (AI), a branch of machine learning (ML) has been increasingly employed in the research of trauma in various aspects. Hemorrhage is the most common cause of trauma-related death. To bett...

    Authors: Henry T. Peng, M. Musaab Siddiqui, Shawn G. Rhind, Jing Zhang, Luis Teodoro da Luz and Andrew Beckett
    Citation: Military Medical Research 2023 10:6

    The Commentary to this article has been published in Military Medical Research 2023 10:43

  23. Osteoarthritis (OA) is the most common type of degenerative joint disease which affects 7% of the global population and more than 500 million people worldwide. One research frontier is the development of hydro...

    Authors: Wang-Lin Duan, Li-Ning Zhang, Raghvendra Bohara, Sergio Martin-Saldaña, Fei Yang, Yi-Yang Zhao, Yong Xie, Ya-Zhong Bu and Abhay Pandit
    Citation: Military Medical Research 2023 10:4
  24. Explosions can produce blast waves, high-speed medium, thermal radiation, and chemical spatter, leading to complex and compound eye injuries. However, few studies have comprehensively investigated the clinical...

    Authors: Ying Zhang, Xin Kang, Qiong Wu, Zhong Zheng, Jun Ying and Mao-Nian Zhang
    Citation: Military Medical Research 2023 10:3
  25. Examining the health outcomes of veterans who have completed the United States Veterans Health Administration’s (VHA’s) Traumatic Brain Injury (TBI) Screening and Evaluation Program may aid in the refinement a...

    Authors: Alexandra L. Clark, Makenna B. McGill, Erin D. Ozturk, David M. Schnyer, Catherine Chanfreau-Coffinier and Victoria C. Merritt
    Citation: Military Medical Research 2023 10:2
  26. Obesity is one of the most serious global health problems, with an incidence that increases yearly and coincides with the development of cancer. Adipose tissue macrophages (ATMs) are particularly important in ...

    Authors: Bei Li, Si Sun, Juan-Juan Li, Jing-Ping Yuan, Sheng-Rong Sun and Qi Wu
    Citation: Military Medical Research 2023 10:1
  27. Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of sepsis. To provide clinical practice recommendations on the immune function in sepsis, an expert consensus...

    Authors: Fei Pei, Ren-Qi Yao, Chao Ren, Soheyl Bahrami, Timothy R. Billiar, Irshad H. Chaudry, De-Chang Chen, Xu-Lin Chen, Na Cui, Xiang-Ming Fang, Yan Kang, Wei-Qin Li, Wen-Xiong Li, Hua-Ping Liang, Hong-Yuan Lin, Ke-Xuan Liu…
    Citation: Military Medical Research 2022 9:74
  28. The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, among which transcriptional regulation is one of the most important components. Alternative splicing...

    Authors: Chun-Xiao Li, Jin-Song Wang, Wen-Na Wang, Dong-Kui Xu, Yan-Tong Zhou, Fang-Zhou Sun, Yi-Qun Li, Feng-Zhu Guo, Jia-Lu Ma, Xue-Yan Zhang, Meng-Jiao Chang, Bing-He Xu, Fei Ma and Hai-Li Qian
    Citation: Military Medical Research 2022 9:71
  29. Traditional treatments for advanced hepatocellular carcinoma (HCC), such as surgical resection, transplantation, radiofrequency ablation, and chemotherapy are unsatisfactory, and therefore the exploration of p...

    Authors: Yi Lu, Yue Gao, Huan Yang, Yong Hu and Xin Li
    Citation: Military Medical Research 2022 9:69

    The Correction to this article has been published in Military Medical Research 2023 10:5

  30. The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic...

    Authors: Min Su, Tao Pan, Qiu-Zhen Chen, Wei-Wei Zhou, Yi Gong, Gang Xu, Huan-Yu Yan, Si Li, Qiao-Zhen Shi, Ya Zhang, Xiao He, Chun-Jie Jiang, Shi-Cai Fan, Xia Li, Murray J. Cairns, Xi Wang…
    Citation: Military Medical Research 2022 9:68
  31. Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. ...

    Authors: Yuan Xiong, Bo-Bin Mi, Ze Lin, Yi-Qiang Hu, Le Yu, Kang-Kang Zha, Adriana C. Panayi, Tao Yu, Lang Chen, Zhen-Ping Liu, Anish Patel, Qian Feng, Shuan-Hu Zhou and Guo-Hui Liu
    Citation: Military Medical Research 2022 9:65
  32. Authors: Anges Yadouleton, Martin Faye, Carine Tchibozo, Mariam Oke, Oumar Faye, Thierry Lawale, Eric Denon, René Keke, Ange Dossou, Alban Zohoun, Francis Dossou, Moussa Moise Diagne, Sourakou Salifou, Khadija Leila Diatta, Mignane Ndiaye, Safietou Sankhe…
    Citation: Military Medical Research 2022 9:63
  33. Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening lung diseases associated with acute and severe inflammation. Both have high mortality rates, and despite decad...

    Authors: Qian Hu, Shu Zhang, Yue Yang, Jia-Qi Yao, Wen-Fu Tang, Christopher J. Lyon, Tony Ye Hu and Mei-Hua Wan
    Citation: Military Medical Research 2022 9:61
  34. Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main purpose of this randomized, double-bl...

    Authors: Ming-Huan Zhu, Zhen-Jing Liu, Qiong-Yue Hu, Jia-Yu Yang, Ying Jin, Na Zhu, Ying Huang, Dian-Hong Shi, Min-Jia Liu, Hong-Yang Tan, Lei Zhao, Qin-Yu Lv, Zheng-Hui Yi, Feng-Chun Wu and Ze-Zhi Li
    Citation: Military Medical Research 2022 9:59
  35. Abnormal myocardial Nav1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO...

    Authors: Chen-Chen Hu, Xin Wei, Jin-Min Liu, Lin-Lin Han, Cheng-Kun Xia, Jing Wu, Tao You, A.-Fang Zhu, Shang-Long Yao, Shi-Ying Yuan, Hao-Dong Xu, Zheng-Yuan Xia, Ting-Ting Wang and Wei-Ke Mao
    Citation: Military Medical Research 2022 9:58