Articles
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Citation: Military Medical Research 2022 9:18
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Supraglottic jet oxygenation and ventilation (SJOV) for resuscitation of injured soldiers and people in war field
Citation: Military Medical Research 2022 9:17 -
Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury
Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of...
Citation: Military Medical Research 2022 9:16 -
Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data
Currently, there is no formal consensus regarding a standard classification for gastric cancer (GC) patients with < 16 retrieved lymph nodes (rLNs). Here, this study aimed to validate a practical lymph node (L...
Citation: Military Medical Research 2022 9:15 -
Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)
Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Tran...
Citation: Military Medical Research 2022 9:14 -
Small molecules facilitate single factor-mediated sweat gland cell reprogramming
Large skin defects severely disrupt the overall skin structure and can irreversibly damage sweat glands (SG), thus impairing the skin’s physiological function. This study aims to develop a stepwise reprogrammi...
Citation: Military Medical Research 2022 9:13 -
Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats
Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, this study aimed to investigate the reg...
Citation: Military Medical Research 2022 9:12 -
Microfluidics-based strategies for molecular diagnostics of infectious diseases
Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing (POCT). Emerging microfluidics, a highly miniaturized, automatic...
Citation: Military Medical Research 2022 9:11 -
Advances in electrical impedance tomography-based brain imaging
Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography (EI...
Citation: Military Medical Research 2022 9:10 -
Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo
Ultrasound-triggered microbubble destruction (UTMD) is a widely used noninvasive technology in both military and civilian medicine, which could enhance radiosensitivity of various tumors. However, little infor...
Citation: Military Medical Research 2022 9:9 -
Wave-shaped microfluidic chip assisted point-of-care testing for accurate and rapid diagnosis of infections
Early diagnosis and classification of infections increase the cure rate while decreasing complications, which is significant for severe infections, especially for war surgery. However, traditional methods rely...
Citation: Military Medical Research 2022 9:8 -
Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer
Citation: Military Medical Research 2022 9:6 -
FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells
Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2 (FGF2) has been reported to be an inflammatory re...
Citation: Military Medical Research 2022 9:7 -
Early prostate specific antigen decline and its velocity are independent predictive factors for outcomes of mCRPC patients treated with abiraterone acetate
Citation: Military Medical Research 2022 9:5 -
Potential roles of vitamin D binding protein in attenuating liver injury in sepsis
In sepsis, vitamin D binding protein (VDBP) has been shown to be low-expressed. The current study examined the relationship between serum VDBP level and liver injury in sepsis patients, as well as in a mouse m...
Citation: Military Medical Research 2022 9:4 -
Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
Bacteria can evolve rapidly by acquiring new traits such as virulence, metabolic properties, and most importantly, antimicrobial resistance, through horizontal gene transfer (HGT). Multidrug resistance in bact...
Citation: Military Medical Research 2022 9:3 -
Military traumatic brain injury: a challenge straddling neurology and psychiatry
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiolo...
Citation: Military Medical Research 2022 9:2 -
Autologous omentum transposition for regeneration of a renal injury model in rats
After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a r...
Citation: Military Medical Research 2022 9:1 -
Cell fusion in the pathogenesis of COVID-19
Citation: Military Medical Research 2021 8:68 -
Advances in the design and development of SARS-CoV-2 vaccines
Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious ...
Citation: Military Medical Research 2021 8:67 -
Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model
The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation ha...
Citation: Military Medical Research 2021 8:61 -
Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model
Musculoskeletal injuries (MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during in...
Citation: Military Medical Research 2021 8:66 -
Estimation of radiation-induced health hazards from a “dirty bomb” attack with radiocesium under different assault and rescue conditions
In the case of a terrorist attack by a “dirty bomb”, blast injuries, external irradiation and the incorporation of radioactivity are to be expected. Departing from information about the radiological attack sce...
Citation: Military Medical Research 2021 8:65 -
Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019
Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack of comprehensive and updated...
Citation: Military Medical Research 2021 8:64 -
Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its highly metastatic and recurrent features, as wel...
Citation: Military Medical Research 2021 8:63 -
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway
Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass pe...
Citation: Military Medical Research 2021 8:62 -
Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...
Citation: Military Medical Research 2021 8:60 -
Regional trauma system development in Shenzhen, China: an 8-year journey
Citation: Military Medical Research 2021 8:59 -
Propofol postconditioning ameliorates hypoxia/reoxygenation induced H9c2 cell apoptosis and autophagy via upregulating forkhead transcription factors under hyperglycemia
Administration of propofol, an intravenous anesthetic with antioxidant property, immediately at the onset of post-ischemic reperfusion (propofol postconditioning, P-PostC) has been shown to confer cardioprotec...
Citation: Military Medical Research 2021 8:58 -
The roles of exosomal immune checkpoint proteins in tumors
Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However, most patients develop adaptive resistance to this therapy. The latest evidence demonstrates ...
Citation: Military Medical Research 2021 8:56 -
Common mtDNA variations at C5178a and A249d/T6392C/G10310A decrease the risk of severe COVID-19 in a Han Chinese population from Central China
Mitochondria have been shown to play vital roles during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) development. Currently, it is unclear whet...
Citation: Military Medical Research 2021 8:57 -
Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling
The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeli...
Citation: Military Medical Research 2021 8:53 -
Dementia in military and veteran populations: a review of risk factors—traumatic brain injury, post-traumatic stress disorder, deployment, and sleep
The military population face a unique set of risk factors that may increase the risk of being diagnosed with dementia. Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) have a higher preva...
Citation: Military Medical Research 2021 8:55 -
Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice, there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Hea...
Citation: Military Medical Research 2021 8:52 -
Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers
Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although periodontitis and genitourinary cancers are two totally distinct types of disorders, epidemiological and clinical studi...
Citation: Military Medical Research 2021 8:54 -
A cross-sectional study of olfactory and taste disorders among COVID-19 patients in China
To determine the prevalence and clinical features of olfactory and taste disorders among coronavirus disease 2019 (COVID-19) patients in China. A cross-sectional study was performed in Wuhan from April 3, 2020...
Citation: Military Medical Research 2021 8:51 -
Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review
By its nature, Gulf war illness (GWI) is multisymptomatic and affects several organ systems in the body. Along with other symptoms, veterans who suffer from GWI commonly report chronic gastrointestinal issues ...
Citation: Military Medical Research 2021 8:50 -
Antimicrobial peptides: mechanism of action, activity and clinical potential
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicro...
Citation: Military Medical Research 2021 8:48 -
Differential roles of RIG-I like receptors in SARS-CoV-2 infection
Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelia...
Citation: Military Medical Research 2021 8:49 -
Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice
SARS-CoV-2 is a newly identified member of the coronavirus family that has caused the Coronavirus disease 2019 (COVID-19) pandemic. This rapidly evolving and unrelenting SARS-CoV-2 has disrupted the lives and ...
Citation: Military Medical Research 2021 8:47 -
Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls
Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.
Citation: Military Medical Research 2021 8:46 -
Advances in single-cell sequencing: insights from organ transplantation
Single-cell RNA sequencing (scRNA-seq) is a comprehensive technical tool to analyze intracellular and intercellular interaction data by whole transcriptional profile analysis. Here, we describe the application...
Citation: Military Medical Research 2021 8:45 -
Data mining in clinical big data: the frequently used databases, steps, and methodological models
Many high quality studies have emerged from public databases, such as Surveillance, Epidemiology, and End Results (SEER), National Health and Nutrition Examination Survey (NHANES), The Cancer Genome Atlas (TCG...
Citation: Military Medical Research 2021 8:44 -
Chronotype and self-reported sleep, alertness, and mental health in U.S. sailors
Service members are at risk for sleep and psychological conditions affecting their readiness. Chronotype (“morningness” or “eveningness”) is strongly associated with sleep, health and performance. The objectiv...
Citation: Military Medical Research 2021 8:43 -
Traumatic brain injury and sight loss in military and veteran populations– a review
War and combat exposure pose great risks to the vision system. More recently, vision related deficiencies and impairments have become common with the increased use of powerful explosive devices and the subsequ...
Citation: Military Medical Research 2021 8:42 -
Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study
The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure (AHF) who do not have hypoxemia. The aim of this study was to investigate the association between oxygen ther...
Citation: Military Medical Research 2021 8:38 -
Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study
Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid over...
Citation: Military Medical Research 2021 8:40 -
Meta-analysis with zero-event studies: a comparative study with application to COVID-19 data
Meta-analysis is a statistical method to synthesize evidence from a number of independent studies, including those from clinical studies with binary outcomes. In practice, when there are zero events in one or ...
Citation: Military Medical Research 2021 8:41 -
Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease, we review...
Citation: Military Medical Research 2021 8:39 -
RIG-I, a novel DAMPs sensor for myoglobin, activates NF-κB/caspase-3 signaling in CS-AKI model
Acute kidney injury (AKI) is the main life-threatening complication of crush syndrome (CS), and myoglobin is accepted as the main pathogenic factor. The pattern recognition receptor retinoicacid-inducible gene...
Citation: Military Medical Research 2021 8:37
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- ISSN: 2054-9369 (electronic)