Articles
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Citation: Military Medical Research 2022 9:41
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The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer
Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15–20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase k...
Citation: Military Medical Research 2022 9:39 -
mRNA vaccine development for cholangiocarcinoma: a precise pipeline
Cholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments, including immune checkpoint blockade therapy. The mRNA vaccine-b...
Citation: Military Medical Research 2022 9:40 -
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.
Citation: Military Medical Research 2022 9:38 -
Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury
Traumatic colon injury (TCI) is a common disease during wartime. Prolongation of posttraumatic survival time is an effective approach to patient outcome improvement. However, there is a lack of basic research ...
Citation: Military Medical Research 2022 9:37 -
Lethal means and suicide prevention among military veterans
Citation: Military Medical Research 2022 9:36 -
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences
The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac ...
Citation: Military Medical Research 2022 9:33 -
TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
Citation: Military Medical Research 2022 9:35 -
Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
Citation: Military Medical Research 2022 9:34 -
Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up
Due to the outbreak and rapid spread of coronavirus disease 2019 (COVID-19), more than 160 million patients have become convalescents worldwide to date. Significant alterations have occurred in the gut and ora...
Citation: Military Medical Research 2022 9:32 -
An unfolding monkeypox outbreak in Europe and beyond
Citation: Military Medical Research 2022 9:31 -
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...
Citation: Military Medical Research 2022 9:30 -
Monkeypox outbreak: A novel threat after COVID-19?
Citation: Military Medical Research 2022 9:29 -
Pushing the frontiers of military medical excellence: updates, progress and future needs
Since its establishment in 2014, Military Medical Research has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with mili...
Citation: Military Medical Research 2022 9:27 -
Molecular diagnostic approaches for enteric parasites: an issue of relevance for deployed soldiers?
Citation: Military Medical Research 2022 9:28 -
Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutat...
Citation: Military Medical Research 2022 9:26 -
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis
Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remai...
Citation: Military Medical Research 2022 9:25 -
Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients
Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral ther...
Citation: Military Medical Research 2022 9:24 -
Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy
LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effe...
Citation: Military Medical Research 2022 9:23 -
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflamm...
Citation: Military Medical Research 2022 9:22 -
Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lun...
Citation: Military Medical Research 2022 9:21 -
Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care f...
Citation: Military Medical Research 2022 9:20 -
N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance
Stemness and chemoresistance contribute to cervical cancer recurrence and metastasis. In the current study, we determined the relevant players and role of N6-methyladenine (m6A) RNA methylation in cervical cancer...
Citation: Military Medical Research 2022 9:19 -
Veterans utilizing a federally qualified health center: a clinical snapshot
Citation: Military Medical Research 2022 9:18 -
Supraglottic jet oxygenation and ventilation (SJOV) for resuscitation of injured soldiers and people in war field
Citation: Military Medical Research 2022 9:17 -
Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury
Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system, which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism, the treatment of...
Citation: Military Medical Research 2022 9:16 -
Standardizing the classification of gastric cancer patients with limited and adequate number of retrieved lymph nodes: an externally validated approach using real-world data
Currently, there is no formal consensus regarding a standard classification for gastric cancer (GC) patients with < 16 retrieved lymph nodes (rLNs). Here, this study aimed to validate a practical lymph node (L...
Citation: Military Medical Research 2022 9:15 -
Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)
Benign prostatic hyperplasia (BPH) is highly prevalent among older men, impacting on their quality of life, sexual function, and genitourinary health, and has become an important global burden of disease. Tran...
Citation: Military Medical Research 2022 9:14 -
Small molecules facilitate single factor-mediated sweat gland cell reprogramming
Large skin defects severely disrupt the overall skin structure and can irreversibly damage sweat glands (SG), thus impairing the skin’s physiological function. This study aims to develop a stepwise reprogrammi...
Citation: Military Medical Research 2022 9:13 -
Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats
Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia (BPH) has not been well understood. Hence, this study aimed to investigate the reg...
Citation: Military Medical Research 2022 9:12 -
Microfluidics-based strategies for molecular diagnostics of infectious diseases
Traditional diagnostic strategies for infectious disease detection require benchtop instruments that are inappropriate for point-of-care testing (POCT). Emerging microfluidics, a highly miniaturized, automatic...
Citation: Military Medical Research 2022 9:11 -
Advances in electrical impedance tomography-based brain imaging
Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography (EI...
Citation: Military Medical Research 2022 9:10 -
Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo
Ultrasound-triggered microbubble destruction (UTMD) is a widely used noninvasive technology in both military and civilian medicine, which could enhance radiosensitivity of various tumors. However, little infor...
Citation: Military Medical Research 2022 9:9 -
Wave-shaped microfluidic chip assisted point-of-care testing for accurate and rapid diagnosis of infections
Early diagnosis and classification of infections increase the cure rate while decreasing complications, which is significant for severe infections, especially for war surgery. However, traditional methods rely...
Citation: Military Medical Research 2022 9:8 -
Alteration of mitochondrial protein succinylation against cellular oxidative stress in cancer
Citation: Military Medical Research 2022 9:6 -
FGF2 is overexpressed in asthma and promotes airway inflammation through the FGFR/MAPK/NF-κB pathway in airway epithelial cells
Airway inflammation is the core pathological process of asthma, with the key inflammatory regulators incompletely defined. Recently, fibroblast growth factor 2 (FGF2) has been reported to be an inflammatory re...
Citation: Military Medical Research 2022 9:7 -
Early prostate specific antigen decline and its velocity are independent predictive factors for outcomes of mCRPC patients treated with abiraterone acetate
Citation: Military Medical Research 2022 9:5 -
Potential roles of vitamin D binding protein in attenuating liver injury in sepsis
In sepsis, vitamin D binding protein (VDBP) has been shown to be low-expressed. The current study examined the relationship between serum VDBP level and liver injury in sepsis patients, as well as in a mouse m...
Citation: Military Medical Research 2022 9:4 -
Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
Bacteria can evolve rapidly by acquiring new traits such as virulence, metabolic properties, and most importantly, antimicrobial resistance, through horizontal gene transfer (HGT). Multidrug resistance in bact...
Citation: Military Medical Research 2022 9:3 -
Military traumatic brain injury: a challenge straddling neurology and psychiatry
Military psychiatry, a new subcategory of psychiatry, has become an invaluable, intangible effect of the war. In this review, we begin by examining related military research, summarizing the related epidemiolo...
Citation: Military Medical Research 2022 9:2 -
Autologous omentum transposition for regeneration of a renal injury model in rats
After renal trauma, surgical treatment is vital, but sometimes there may be loss of function due to fibrosis. This study aimed to evaluate the effect of autologous omentum flaps on injured renal tissues in a r...
Citation: Military Medical Research 2022 9:1 -
Cell fusion in the pathogenesis of COVID-19
Citation: Military Medical Research 2021 8:68 -
Advances in the design and development of SARS-CoV-2 vaccines
Since the end of 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The RNA genome of SARS-CoV-2, which is highly infectious ...
Citation: Military Medical Research 2021 8:67 -
Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model
The healing of bone defects can be challenging for clinicians to manage, especially after exposure to ionizing radiation. In this regard, radiation therapy and accidental exposure to gamma (γ)-ray radiation ha...
Citation: Military Medical Research 2021 8:61 -
Risk factors for musculoskeletal injuries in the military: a qualitative systematic review of the literature from the past two decades and a new prioritizing injury model
Musculoskeletal injuries (MSkIs) are a leading cause of health care utilization, as well as limited duty and disability in the US military and other armed forces. MSkIs affect members of the military during in...
Citation: Military Medical Research 2021 8:66 -
Estimation of radiation-induced health hazards from a “dirty bomb” attack with radiocesium under different assault and rescue conditions
In the case of a terrorist attack by a “dirty bomb”, blast injuries, external irradiation and the incorporation of radioactivity are to be expected. Departing from information about the radiological attack sce...
Citation: Military Medical Research 2021 8:65 -
Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019
Urinary tract infections (UTI), urolithiasis, and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However, there is still a lack of comprehensive and updated...
Citation: Military Medical Research 2021 8:64 -
Excellent effects and possible mechanisms of action of a new antibody–drug conjugate against EGFR-positive triple-negative breast cancer
Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15–20% of diagnosed breast cancers. TNBC is characterized by its highly metastatic and recurrent features, as wel...
Citation: Military Medical Research 2021 8:63 -
Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway
Disruption of the blood–brain barrier (BBB) after a stroke can lead to brain injury and neurological impairment. Previous work confirmed the involvement of the immunoproteasome subunit of low molecular mass pe...
Citation: Military Medical Research 2021 8:62 -
Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990–2019
The burden of kidney, bladder, and prostate cancers has changed in recent decades. This study aims to investigate the global and regional burden of, and attributable risk factors for genitourinary cancers duri...
Citation: Military Medical Research 2021 8:60
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- ISSN: 2054-9369 (electronic)