Skip to main content

Contemporary approaches to visual prostheses

A Publisher Correction to this article was published on 07 August 2019

This article has been updated


Visual prostheses serve to restore visual function following acquired blindness. Acquired blindness (as opposed to congenital blindness) has many causes, including diseases such as retinitis pigmentosa, glaucoma, and macular degeneration, or trauma such as caused by automobile accident or blast damage from explosions. Many of the blindness-causing diseases target the retina or other ocular structure. Often, despite the loss of sensitivity to light, the remainder of the visual pathway is still functional, enabling electrical devices to deliver effective and meaningful visual information to the brain via arrays of electrodes. These arrays can be placed in any part of the early visual pathway, such as the retina, optic nerve, lateral geniculate nucleus, or visual cortex. A camera or other imaging source is used to drive electrical stimulation of remaining healthy cells or structures to create artificial vision and provide restoration of function. In this review, each approach to visual prostheses is described, including advantages and disadvantages as well as assessments of the current state of the art. Most of the work to-date has been targeting stimulation of (a) the retina, with three devices approved for general use and two more in clinical testing; (b) the lateral geniculate nucleus, with efforts still in the pre-clinical stage; and (c) the cortex, with three devices in clinical testing and none currently approved for general use despite the longest history of investigation of the three major approaches. Each class of device has different medical indications, and different levels of invasiveness required for implantation. All contemporary devices deliver relatively poor vision. There has been remarkable progress since the first proof-of-concept demonstration that used stimulation of the primary visual cortex, with the field exploring all viable options for restoration of function. Much of the progress has been recent, driven by advances in microelectronics and biocompatibility. With three devices currently approved for general use in various parts of the world, and a handful of additional devices well along in the pipeline toward approval, prospects for wide deployment of a device-based therapy to treat acquired blindness are good.


Visual prostheses are devices intended to restore lost visual function via the use of electronic circuitry and electrical impulses. With an estimated 36 million and growing blind individuals, the significance of a cure for blindness is clear and increasing [1]. Visual prostheses can provide benefit to those with severe vision loss, especially if no other medical treatment options exist.

Experimental work in visual prosthetics started in earnest in the early 1900s and has grown since then (excellent historical perspectives have been written by Donaldson and Brindley [2], and Lewis and Rosenfeld [3]). In 1929, Foerster [4], quickly followed by Krause and Schum in 1931 [5] stimulated brain areas at the occipital pole, creating phosphenes — small, electrically-evoked visual percepts. These observations were amplified by Button and Putnam [6] who demonstrated independent, punctate phosphenes through multiple channels of cortical stimulation. Brindley and Lewin then embarked on a series of experiments that included a ground-breaking report in 1968 [7] describing the first implant to generate sufficiently many phosphenes to convey visually-based patterns [8, 9]. Brindley and Lewin’s seminal work, along with advances in technological miniaturization and biocompatibility, and parallel efforts to treat Parkinson’s disease, chronic pain, and hearing loss [10,11,12], led to an acceleration of research through the last few decades that has expanded the number of efforts to the present dozens of groups working world-wide on visual prosthesis devices.

Normal function of the visual pathway (Fig. 1) begins with light entering the eye and being converted into neural signals by the photoreceptors of the retina. These neural signals are then sent by the retinal ganglion cells along the optic nerve formed by their axons to the lateral geniculate nucleus (LGN). From the LGN, signals propagate along the optic radiation to the primary visual cortex (V1). From V1, the central visual signal path begins to fan out quickly to areas of the brain that specialize in visual function.

Fig. 1
figure 1

A ventral view of the human brain showing the early visual pathway. Normally, light enters the system through the optics of the eyes, and is focused on the retina where photons are converted to neural activity. From the retina, this activity flows down the optic nerves and through the chiasm, along the optic tract to the lateral geniculate nucleus of the thalamus (LGN). The chiasm serves to sort fibers from the two eyes such that signals are combined by visual hemifield (both right hemifields go to the left LGN, and vice-versa). From the LGN, signals then flow through the optic radiation to the primary visual cortex (V1), and on to the higher visual areas

Depending on the etiology of blindness, a variety of anatomically-targeted approaches along the visual pathway are viable. For example, retinitis pigmentosa (RP) causes degeneration of the rods and cones that constitute the primary photosensitive cells in the retina, although the inner nuclear layer and retinal ganglion cell layer are unaffected until the disease reaches later stages [13]. Therefore, stimulation of the remaining healthy retina is an option; this option is especially compelling given that no other treatments for late-stage RP currently exist [13]. However, if the retina has degenerated beyond possible stimulation or if damage has occurred further down the visual pathway, such as in glaucoma that affects the optic nerve, the remainder of the visual pathway is frequently intact and viable, allowing prosthetic stimulation to be successfully applied later along the visual stream [14]. Currently, the majority of visual prosthesis research has centered on the retina, with other, non-retinal approaches remaining somewhat more experimental.

Besides current technological approaches to cure blindness, several biological approaches exist, although each comes with both benefits and disadvantages. Gene therapy has focused on loss of function mutations in which introducing a wild-type gene can potentially restore function [15]. This approach has been successful in clinical preservation or partial restoration of vision in Leber’s congenital amaurosis [16, 17] and choroderemia [18]. However, gene therapy is limited to recessive mutations [15]. Optogenetic approaches aim to activate residual retinal cells by transfection with viral carriers that express light-sensitive cell-membrane ion channels and thus confer phososensitivity. Although converted cells still require a high level of light and a successful intervention requires a reasonably large population of surviving retinal cells [19, 20], efficacy has been shown in a primate model [21, 22] and clinical trials are ongoing for treating retinitis pigmentosa ( registration numbers NCT02556736, NCT03326336). Both of these approaches require unaffected retinal tissue and are thus most applicable to earlier stages of retinal degenerative diseases prior to the extensive retinal remodeling that is observed in advanced stages [23, 24].


The following paragraphs will describe the current approaches to visual prosthesis devices, organized by location of approach and following along the natural flow of information in the early visual pathway: retina, optic nerve, lateral geniculate nucleus (LGN), and visual cortex (see Fig.1; to the best of our knowledge, there is no current effort attempting sight restoration using the optic radiation that projects from the lateral geniculate nucleus to visual cortex). The advantages and disadvantages of each approach will be described, as well as the current research being conducted and clinical testing or deployment if any. Important previous reports upon which we build here include the excellent compendium “Artificial Vision” edited by Gabel [25], and review articles by Weiland et al. [26], Fernandes et al. [27], and Lewis et al. [28]. Our present contribution to the field is to include a more detailed look at the thalamic approach, and to guide the reader toward projects that currently have ongoing clinical trials.

Visual prostheses


The retina is a major focus for visual prostheses. Various structures of the retina can be targeted for electrical stimulation, including the outer layer of light-sensitive photoreceptor cells, inner layer of bipolar cells, and the layer of retinal ganglion cells whose axons form the optic nerve [29]. Photoreceptor cells consist of cone cells that support high-acuity color vision, and rod cells that support low light level vision. By simplification, photoreceptors synapse with bipolar cells which subsequently synapse with retinal ganglion cells. The retina is frequently chosen as a visual prosthesis target for a number of reasons: its extracranial location allows easy surgical access, and an implant in a single eye can potentially cover nearly the entire visual field [30]. The retina's simpler architectual organization as compared to locations further down the visual stream is appealing as well [31]. Additionally, even with advanced degeneration, sufficiently many retinal neurons are frequently still present and capable of generating signals to convey images [32].

However, the retinal approach has several disadvantages. The retina is delicate and has varying availability across its extent, which can restrict electrode count, field of view, and subsequent visual acuity [31, 32]. Retinal diseases may lead to retinal reorganization, complicating known retinal maps, stimulation parameters, and evoked percepts [29]. Furthermore, successful retinal implants require a significant number of remaining retinal ganglion cells, limiting scope and applicability [33]. Ailments affecting later points of the visual stream, including glaucoma or traumatic injuries, cannot be aided with such prostheses [34]. For degenerative retinal diseases whose progression can affect the number of retinal cells remaining, prosthesis designers need to take retinal state into account to achieve success [35].

Retinal prostheses frequently follow one of two formats: (1) an electrode array driven by an external camera via a visual processing unit stimulates retinal tissue or (2) an intraocular photodiode array converts light energy into electrical signals to activate nearby retinal cells [35,36,37,38,39,40,41,42,43]. Typical epiretinal prosthesis designs such as the Argus II, have an electrode array implanted on the inner surface of the retina, adjacent to the vitreous humor, targeting the retinal ganglion cell layer. Usually epiretinal prostheses have an external imaging source, such as a miniature video camera mounted into a set of goggles. Typical subretinal prosthesis designs have an electrode array implanted on the outer layer of the retina and target adjacent bipolar cells. Often subretinal prostheses integrate the imaging sensor with the electrode array, such as the Alpha AMS, with the intention of replacing failed photoreceptor cells with photodiodes. Typical suprachoroidal prosthesis designs have an electrode array implanted between the choroid and sclera or on the sclera and target retinal ganglion cells. They also typically use an external camera similar to the epiretinal prosthesis. The following sections describe each approach and its benefits and challenges in further detail.

Epiretinal prosthesis

An epiretinal prosthesis is implanted on the surface of the retina at the vitreous cavity, often secured with a tack, and transmits information from a camera to stimulate the retinal ganglion cells [35]. Its proximity to the retina allows for a low stimulation threshold which in turn allows for a smaller size, while contact with the vitreous cavity fluids helps dissipate heat from the device [35, 44]. While having a processing unit between the camera and the simulating array can allow for substantial image analysis and manipulation, such systems typically require head movement from the user to steer the camera, not the more natural eye-and-head combination [31, 34, 45]. The conventional use of a tack to anchor the electrode array may also be considered a disadvantage, as it possibly causes retinal damage and long-term mechanical stability issues [34]. Finally, the retinal ganglion cell stimulation must be highly targeted to the cell bodies to avoid unintended activation of fibers originating from other parts of the retina which may pass under the electrodes [46]. While initial work focused on feasibility, especially with retinitis pigmentosa patients, the epiretinal approach has advanced the farthest within the field, with devices receiving governmental approval for clinical use in both the United States and Europe [46, 47]. Limitations of the epiretinal approach include acuity that is quite low compared to normal vision [35], difficulty changing phosphene color [48], and, importantly, a field of vision restricted to the typically small span of the electrode array [49]. As we will see below, subretinal devices often share many of these factors.

Currently, the only visual prosthesis to have received both United States Food and Drug Administration (FDA) and European Commission (CE) approval, both for use against Retinitis Pigmentosa, is Second Sight’s Argus II: a 60-electrode epiretinal array receiving visual information wirelessly from an external camera mounted on a set of glasses [35,36,37, 50]. The Argus II has enabled patients to read, albeit slowly, recognize words, and detect motion, with a maximum visual acuity of 20/1260 over a highly-limited visual field [35, 37, 50]. Device safety has been evaluated, and the device appears to be well tolerated and safe. In a five year trial, 60% of patients had no serious adverse events, although common but less serious effects included conjunctival erosion and ocular hypotony [36]. One retinal detachment, a frequent concern with retinal implants, was recorded [36]. While the Argus II is the most established epiretinal device, others are not far behind in development. For example, the IRIS 2 [51] carries a CE mark for use with outer retinal degeneration, and is being tested in an ongoing clincal trial for additional indications (NCT02670980), along with the EPIRET3 that has been successfully implanted and well tolerated in RP patients [52, 53]. We expect to see additional progress for epiretinal efforts in the near future.

Subretinal prosthesis

With an array that combines electronic photosensors and stimulating contacts and is positioned on the outer retina, subretinal prostheses are designed to replace lost or malfunctioning photoreceptors with photodiodes, an attractive method given that even in highly degenerated retinas, neural activity can be evoked by prosthetic electrical stimulation [38]. The subretinal location of the photosensitive aspect of the array enables such devices to take advantage of both natural eye movements and retinal circuitry, and recipients can use a subretinal prosthesis with little learning effort [54]. Additionally, intimate proximity of the stimulating contacts to the retinal circuitry allows for lower stimulation thresholds than with other approaches [44]. The limited available space, while restricting implant thickness and power, allows subretinal prostheses to be held in place without a tack [29, 54]. Further constraints of the subretinal approach that are largely shared with the epiretinal approach include the limited possible visual acuity using photodiodes (an expected maximum of Snellen 20/250 due to limitations based on current spread), the lack of color perception, and the limited field of vision, which is constrained to only the extent of the array as it serves as both imaging device and stimulator [40, 41]. Typical designs, such as the Alpha AMS which is described in more detail below, are sensitive to and image natural light directly, eliminating the need for an external camera; the current sole exception is the PRIMA device [55] that uses infrared-sensitive photodiodes and encodes the visual scene from an external camera into infra-red images to drive its array. Having an external camera and image processing, such as used with typical epiretinal implants, creates a significant functional advantage for the PRIMA device over other subretinal devices. With the Alpha AMS, for example, image processing is limited by the room for local circuitry on the implant itself, and currently supports only basic contrast and gain control [40, 41].

Similar to the epiretinal approach, one subretinal series of devices has received governmental approval in Europe: Retina Implant AG’s Alpha IMS and its successor the Alpha AMS. Given that the AMS has replaced the IMS for clinical purposes (including extension of the original CE mark to the new device), we will concentrate on the newer, and largely improved AMS for this report [42]. For a comparative technical evaluation of the two devices, see, for example the report by Daschner et al. [43]. The Alpha AMS consists of an array of 1600 photodiodes that is implanted in the outer retina. The photodiodes convert light to current that is used to stimulate adjacent bipolar cells [39,40,41,42, 56]. Implanted patients have been able to read letters, combine letters into words, perceive and localize light, detect motion, navigate familiar locations, and identify and grasp objects [39, 42, 56]. The highest visual acuity measured was Snellen 20/546, an important improvement compared to both epiretinal and suprachoroidal prostheses, as well as current non-retinal devices [21, 24, 25, 34]. The Alpha IMS and AMS devices have shown similar adverse effects as the epiretinal Argus II, with the most common events being elevated intraocular pressure (IOP), conjuctival erosion, and retinal detachment; each of these events were associated with device implantation and removal respectively and all adverse events were successfully resolved [42, 57]. IOP was seen shortly after device implantation in one case, and retinal detachment was associated with device removal in one case as well.

As mentioned above, an important subretinal prosthesis currently undergoing clinical testing is the PRIMA device (NCT03333954) [55, 58]. This design uses an array of photodiodes that convert varying intensities of infra-red illumination to localized electrical stimulation of retinal tissue. Externally-worn goggles amplify the video stream from a conventional camera into bright infrared illumination that is focused by the optics of the eye onto the implanted array. This hybrid approach of translating the external visual field into an infrared image, potentially modifying it along the way, delivered with sufficient brightness to power the local circuitry at each photosensitive cell, has substantial promise. Along with the Alpha AMS, it remains one of the few retinal approaches that supports visual exploration through normal eye movements.

Suprachoroidal prosthesis

Finally, the suprachoidal retinal prosthesis is implanted between the choroid and sclera, or in the scleral pocket for the suprachoroidal-transretinal variant, and stimulates retinal neurons. The position of the suprachoidal prosthesis intends to avoid retinal damage that can be caused by direct contact [29]. The scleral pocket provides mechanical stability, while the choroid blood vessels aid in heat dissipation [33, 44]. In addition, the retinally-removed location facilitates a less challenging surgery than other visual prostheses [44]. While beneficial in some respects, the distance from the retina requires suprachoroidal prostheses to stimulate through the higher electrical resistance of the retinal pigment epithelium, resulting in higher stimulation thresholds which can increase the risk of damage [59]. Furthermore, the higher thresholds and subsequently higher charge injection requirements increase the impact of current spreading, which results in decreased visual contrast and resolution [33].

Currently, no suprachoroidal prostheses have been approved beyond Phase 1 clinical trials [33, 60]. Fujikado et al. [33] implanted a suprachoroidal-transretinal prosthesis in several RP patients, eliciting percepts with no serious adverse events. In addition, Ayton and colleagues successfully implanted a device that allowed late-stage RP patients to localize light and recognize letters, although with an optotype acuity of approximately 20/8000 [60].

Optic nerve

If intact, the optic nerve is an interesting potential target for visual replacement: the optic nerve has an extracranial segment and thus can be accessed with minimally invasive surgery, and would support a full field view despite a high level of retinal cell disease [30, 61]. Evoked potentials via the optic nerve have been shown to have the same wave shape as normal visual potentials, further providing support for the optic nerve, and prior reports have described a decreasing stimulation threshold over long periods of device implantation [62, 63]. Still, optic nerve stimulation has thus far been demonstrated with only low resolution and low apparent brightness, requiring high stimulation to evoke percepts, and while the optic nerve approach is attractive in part due to a potentially simple surgical implantation, it still requires an active nerve [61, 62]. Optic nerve prostheses can take two forms: cuff electrodes and penetrating electrodes [61, 62, 64,65,66,67,68]. Current optic nerve researchers have generated phosphenes in RP patients, as well as demonstrated object localization and identification, albeit with very long recognition times [61, 65].

Lateral geniculate nucleus

The lateral geniculate nucleus is a visual relay center within the thalamus, receiving input from the optic nerve and forwarding information to the visual cortex. The LGN has become an increasingly attractive target to researchers given that advances in deep brain stimulation have created easy surgical access to the thalamus [69]. Additionally, the compact structure of the LGN supports a wide prosthetic visual field, and the overrepresentation of the fovea is thought to allow for higher acuity vision than other approaches [30, 70]. Additional anatomical benefits include the simple and well characterized receptive fields and the separated visual subdivisions of the LGN that may support color artificial vision [69, 70]. Full visual field coverage would require two separate arrays, one in each hemisphere, as the LGN is post optic-chiasm and like all subsequent visual areas, each hemisphere represents only one half of the visual field [30]. Current LGN research has affirmed that stimulation can produce phosphenes and that such stimulation produces similar responses in the visual cortex as natural visual stimulation [69, 70].

Visual cortex

The visual cortex was among the first locations considered for a visual prosthesis, with seminal work by Brindley and Lewin inducing phosphenes in the late 1960s [7]. In addition, the first complete visual prosthesis was a cortical device, developed by Dobelle and colleagues some 30 years later [71]. Since then, substantial additional effort has focused on the visual cortex due to its large surface area, straightforward stimulation procedure, and applicability to all forms of blindness other than cortical injury or stroke [3, 28]. The use of penetrating intracortical rather than surface stimulation has enabled researchers to stimulate at greatly lower current levels than expected, as well as allowing for closely-spaced electrodes [72]. However, similar to the retina, the cortex may experience reorganization after blindness, complicating phosphene mapping, and, similar to many other prostheses, current designs for cortical prosthesis rely on head-steering of the scene camera and do not make use of eye movement [28, 73]. Most recently, Second Sight, developers of the Argus II retinal prosthesis, have received conditional FDA approval for clinical trials of the Orion Cortical Visual Prosthesis System [74] (NCT03344848), the Universidad Miguel Hernandez de Elche in Spain has begun a clinical study on the CORTIVIS device (NCT02983370), and UCLA is running a clinical study on the NeuroPace RNS System (NCT02747589). Several other groups have cortical prostheses in various states of development as well [75,76,77,78,79].

Clincal trials

The current list of clinical trials that have registered with the US National Library of Medicine ( for visual prosthesis devices is found in Table 1. As can be seen from the list there are a small number of efforts that have advanced to the stage of clinical trial with their device. The number of research groups working on devices that have not yet advanced to the clinical stage is substantially larger, with some two dozen currently known (see, for example, the list at Note that the list in Table 1 excludes drug-based interventions as mentioned earlier, as well as non-invasive sensory-substitution devices like BrainPort [80] and The vOICe [81].

Table 1 Current clinical trials of visual prosthesis devices

Table 1 shows the current status of clinical trials for visual prostheses that have registered with the US National Library of Medicine (, organized by device type. Completed trials are not shown. For each trial, the title and sponsors are given, along with the current status (A – Active, not recruiting; E – Enrolling by invitation; R – Recruiting; U – Status unknown), the indicated disease (AMD – Age-related Macular Deveneration; B – Blindness; Ba – Blindness, acquired; C – Choroidermia; CRD – Cone Rod Dystrophy; dAMD – Dry Age-related Macular Degeneration; oRD – Outer Retinal Degeneration; RD – Inherited Retinal Dystrophy; RP – Retinitis Pigmentosa), the device associated with the clinical trial, and the date of the most recent update posted to

Conclusions and future directions

The field of visual prostheses has grown rapidly in the recent years, from proof-of-principle demonstrations that generated simple percepts in 1968 to multiple devices granted FDA and CE approval for clinical use [7, 36, 41, 51]. Research has confirmed that several structures of the early visual pathway are viable as targets to restore vision: retina, optic nerve, LGN, and visual cortex. While each approach comes with advantages and disadvantages, research on the retinal approach has advanced the farthest.

As previously described, the retinal prostheses can be separated into three varied approaches: epiretinal, subretinal, and suprachoroidal. The epiretinal approach places stimulation arrays on the inner limiting membrane, close to the retinal ganglion cells, allowing for low electrical thresholds but at the cost of potential retinal damage and off-target stimulation. The subretinal approach places imaging and stimulating arrays within the thin sheet of retinal tissue, allowing such devices to have reduced stimulation thresholds and to take advantage of natural eye movements and any remaining retinal circuitry. However, practical concerns about the extent of implants within the ocular structure limit the extent of the visual field that currently can be stimulated, and the retinal architecture may place an ultimate limit on visual acuity for both epi-and sub-retinal approaches that is not present for thalamic and cortical approaches. The suprachoroidal approach avoids retinal damage and visual field extent constraints by positioning stimulating electrodes outside of the retina, in a scleral pocket, but requires higher levels of stimulation to achieve similar effects and has inherently poorer potential resolution.

Devices targeting the different stages of the early pathway have been variously shown to improve light detection, character recognition, and mobility, although future work clearly remains to progress beyond the very crude level of vision afforded by current devices. Specifically, determining the optimal prosthesis location and further developing prosthesis technology would immensely advance the field and provide patient benefit. Given that each approach has its advantages and weaknesses, including appropriateness for disease stage and etiology, device choice must be carefully considered to best enhance vision in patients. Efforts to address electrode count and spacing, to sharpen visual acuity and expand visual field area, as well as size constraints, power constraints, and external image processing will advance the quality of artificial vision for recipients. Overall, despite current limitations in resolution and applicable disease conditions, visual prostheses have shown great potential for positive impact on patient lives, and this potential will only increase with additional research and development.

Change history

  • 07 August 2019

    An error occurred during the publication of a number of articles in Military Medical Research.


CE Mark:

Aapproval for drugs or devices given by the European Commission


European Commission


United States Food and Drug Administration


Intraocular pressure


Lateral geniculate nucleus of the thalamus


Retina ganglion cell


Retinitis pigmentosa


Primary visual cortex


  1. Bourne RRA, Flaxman SR, Braithwaite T, Cicinelli MV, Das A, Jonas JB, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e888–97.

    Article  PubMed  Google Scholar 

  2. Donaldson N, Brindley GS. The historical foundations of bionics//Donaldson N, Brindley GS. Eds. Neurobionics: the biomedical engineering of neural prostheses. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016: 1–37.

  3. Lewis PM, Rosenfeld JV. Electrical stimulation of the brain and the development of cortical visual prostheses: an historical perspective. Brain Res. 2016;1630:208–24.

    Article  CAS  PubMed  Google Scholar 

  4. Foerster O. Beiträge zur Pathophysiologie der Sehbahn und der Sehsphäre. J Psychol Neurol. 1929;39:463–85.

    Google Scholar 

  5. Krause F, Schum H. Die epileptischen Erkrankungen. In: Kuttner H, editor. Neue Deutsche Chirurgie, vol. 49a. Stuttgart: Enke; 1931. p. 482–6.

    Google Scholar 

  6. Button J, Putnam T. Visual responses to cortical stimulation in the blind. J Iowa State Med Soc. 1962;52:17–21.

    Google Scholar 

  7. Brindley GS, Lewin WS. The sensations produced by electrical stimulation of the visual cortex. J Physiol Lond. 1968;196(2):479–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Brindley GS, Donaldson PE, Falconer MA, Rushton DN. The extent of the region of occipital cortex that when stimulated gives phosphenes fixed in the visual field. J Physiol. 1972;225(2):57–8.

    Google Scholar 

  9. Donaldson PEK. Experimental visual prosthesis. Proc Inst Electr Eng. 1973;120(2):281.

    Article  Google Scholar 

  10. Williams NR, Okun MS. Deep brain stimulation (DBS) at the interface of neurology and psychiatry. J Clin Invest. 2013;123(11):4546–56.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Plow EB, Pascual-Leone A, Machado A. Brain stimulation in the treatment of chronic neuropathic and non-cancerous pain. J Pain. 2012;13(5):411–24.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wilson BS, Dorman MF. Cochlear implants: a remarkable past and a brilliant future. Hear Res. 2008;242(1/2):3–21.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Hartong DT, Berson EL, Dryja TP. Retinitis pigmentosa. Lancet. 2006;368(9549):1795–809.

    Article  CAS  PubMed  Google Scholar 

  14. Gupta N, Ang L-C, Noël de Tilly L, Bidaisee L, Yücel Y. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol. 2006;90:674–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Gupta PR, Huckfeldt RM. Gene therapy for inherited retinal degenerations: initial successes and future challenges. J Neural Eng. 2017;14(5):051002.

    Article  PubMed  Google Scholar 

  16. Kumaran N, Moore AT, Weleber RG, Michaelides M. Leber congenital amaurosis/early-onset severe retinal dystrophy: clinical features, molecular genetics and therapeutic interventions. Br J Ophthalmol. 2017;101(9):1147–54.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, et al. Effect of gene therapy on visual function in Leber’s congenital amaurosis. N Engl J Med. 2008;358(21):2231–9.

    Article  CAS  PubMed  Google Scholar 

  18. MacLaren RE, Groppe M, Barnard AR, Cottriall CL, Tolmachova T, Seymour L, et al. Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial. Lancet. 2014;383(9923):1129–37.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Barrett JM, Berlinguer-Palmini R, Degenaar P. Optogenetic approaches to retinal prosthesis. Vis Neurosci. 2014;31(4–5):345–54.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Busskamp V, Picaud S, Sahel JA, Roska B. Optogenetic therapy for retinitis pigmentosa. Gene Ther. 2012;19(2):169–75.

    Article  CAS  PubMed  Google Scholar 

  21. Ivanova E, Hwang GS, Pan ZH, Troilo D. Evaluation of AAV-mediated expression of Chop2-GFP in the marmoset retina. Invest Ophthalmol Vis Sci. 2010;51(10):5288–96.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Chaffiol A, Caplette R, Jaillard C, Brazhnikova E, Desrosiers M, Dubus E, et al. A new promoter allows optogenetic vision restoration with enhanced sensitivity in macaque retina. Mol Ther. 2017;25(11):2546–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Jones BW, Marc RE. Retinal remodeling during retinal degeneration. Exp Eye Res. 2005;81(2):123–37.

    Article  CAS  PubMed  Google Scholar 

  24. Jones BW, Pfeiffer RL, Ferrell WD, Watt CB, Marmor M, Marc RE. Retinal remodeling in human retinitis pigmentosa. Exp Eye Res. 2016;150:149–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Gabel VP. Artificial vision: a clinical guide. Cham: Springer International Publishing; 2017.

    Book  Google Scholar 

  26. Weiland JD, Liu W, Humayun MS. Retinal prosthesis. Annu Rev Biomed Eng. 2005;7:361–401.

    Article  CAS  PubMed  Google Scholar 

  27. Fernandes RA, Diniz B, Ribeiro R, Humayun M. Artificial vision through neuronal stimulation. Neurosci Lett. 2012;519(2):122–8.

    Article  CAS  PubMed  Google Scholar 

  28. Lewis PM, Ackland HM, Lowery AJ, Rosenfeld JV. Restoration of vision in blind individuals using bionic devices: a review with a focus on cortical visual prostheses. Brain Res. 2015;1595:51–73.

    Article  CAS  PubMed  Google Scholar 

  29. Hadjinicolaou AE, Meffin H, Maturana MI, Cloherty SL, Ibbotson MR. Prosthetic vision: devices, patient outcomes and retinal research. Clin Exp Optom. 2015;98(5):395–410.

    Article  PubMed  Google Scholar 

  30. Pezaris JS, Eskandar EN. Getting signals into the brain: visual prosthetics through thalamic microstimulation. Neurosurg Focus. 2009;27(1):E6.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Luo YHL, da Cruz L. A review and update on the current status of retinal prostheses (bionic eye). Br Med Bull. 2014;109(1):31–44.

    Article  PubMed  Google Scholar 

  32. Kohler K, Hartmann JA, Werts D, Zrenner E. Histological studies of retinal degeneration and biocompatibility of subretinal implants. Ophthalmologe. 2001;98(4):364–8.

    Article  CAS  PubMed  Google Scholar 

  33. Fujikado T, Kamei M, Sakaguchi H, Kanda H, Endo T, Hirota M, et al. One-year outcome of 49-channel suprachoroidal-transretinal stimulation prosthesis in patients with advanced retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2016;57(14):6147–57.

    Article  CAS  PubMed  Google Scholar 

  34. Shepherd RK, Shivdasani MN, Nayagam DA, Williams CE, Blamey PJ. Visual prostheses for the blind. Trends Biotechnol. 2013;31(10):562–71.

    Article  CAS  PubMed  Google Scholar 

  35. da Cruz L, Coley BF, Dorn J, Merlini F, Filley E, Christopher P, et al. The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss. Br J Ophthalmol. 2013;97(5):632–6.

    Article  PubMed  PubMed Central  Google Scholar 

  36. da Cruz L, Dorn JD, Humayun MS, Dagnelie G, Handa J, Barale PO, et al. Five-year safety and performance results from the Argus II retinal prosthesis system clinical trial. Ophthalmology. 2016;123(10):2248–54.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Humayun MS, Dorn JD, da Cruz L, Dagnelie G, Sahel JA, Stanga PE, et al. Interim results from the international trial of second sight’s visual prosthesis. Ophthalmology. 2012;119(4):779–88.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Zrenner E, Stett A, Weiss S, Aramant RB, Guenther E, Kohler K. Can subretinal microphotodiodes successfully replace degenerated photoreceptors ? Vis Res. 1999;39(15):2555–67.

    Article  CAS  PubMed  Google Scholar 

  39. Stingl K, Bartz-Schmidt KU, Besch D, Braun A, Bruckmann A, Gekeler F, et al. Artificial vision with wirelessly powered subretinal electronic implant alpha-IMS. Proc R Soc B Biol Sci. 2013;280(1757):20130077.

    Article  Google Scholar 

  40. Stingl K, Bartz-Schmidt KU, Besch D, Chee CK, Cottriall CL, Gekeler F, et al. Subretinal visual implant alpha IMS--clinical trial interim report. Vis Res. 2015;111(Pt B):149–60.

    Article  PubMed  Google Scholar 

  41. Stingl K, Schippert R, Bartz-Schmidt KU, Besch D, Cottriall CL, Edwards TL, et al. Interim results of a multicenter trial with the new electronic subretinal implant alpha AMS in 15 patients blind from inherited retinal degenerations. Front Neurosci. 2017;11:445.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Edwards TL, Cottriall CL, Xue K, Simunovic MP, Ramsden JD, Zrenner E, et al. Assessment of the electronic retinal implant alpha ams in restoring vision to blind patients with end-stage retinitis pigmentosa. Ophthalmology. 2018;125(3):432–43.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Daschner R, Rothermel A, Rudorf R, Rudorf S, Stett A. Functionality and performance of the subretinal implant chip alpha AMS. Sens Mater. 2018;30(2):179–92.

    Google Scholar 

  44. Bareket L, Barriga-Rivera A, Zapf MP, Lovell NH, Suaning GJ. Progress in artificial vision through suprachoroidal retinal implants. J Neural Eng. 2017;14(4):045002.

    Article  PubMed  Google Scholar 

  45. Paraskevoudi N, Pezaris JS. Eye movement compensation and spatial updating in visual prosthetics: mechanisms, limitations and future directions. Front Syst Neurosci. 2019;12:73.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Humayun MS, Weiland JD, Fujii GY, Greenberg R, Williamson R, Little J, et al. Visual perception in a blind subject with a chronic microelectronic retinal prosthesis. Vis Res. 2003;43(24):2573–81.

    Article  PubMed  Google Scholar 

  47. Keserü M, Feucht M, Bornfeld N, Laube T, Walter P, Roessler G, et al. Acute electrical stimulation of the human retina with an epiretinal electrode array. Acta Ophthalmol. 2012;90(1):e1–8.

    Article  PubMed  Google Scholar 

  48. Stanga PE, Sahel JA Jr, daCruz L, Hafezi F, Merlini F, Coley B, et al. Patients blinded by outer retinal dystrophies are able to perceive simultaneous colors using the Argus II retinal prosthesis system. Investig Ophthalmol Vis Sci. 2012;53:6952.

    Google Scholar 

  49. Rizzo S, Belting C, Cinelli L, Allegrini L, Genovesi-Ebert F, Barca F, et al. The Argus II retinal prosthesis: 12-month outcomes from a single-study center. Am J Ophthalmol. 2014;157(6):1282–90.

    Article  PubMed  Google Scholar 

  50. Dorn JD, Ahuja AK, Caspi A, da Cruz L, Dagnelie G, Sahel JA, et al. The detection of motion by blind subjects with the epiretinal 60-electrode (Argus II) retinal prosthesis. JAMA Ophthalmol. 2013;131(2):183–9.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Hornig R, Dapper M, Le Joliff E, Hill R, et al., Pixium Vision: first clinical results and innovative developments//Hornig R, Dapper M, Le Joliff E, et al. eds. Artificial Vision. Cham: Springer International Publishing, 2016; 99–113.

    Google Scholar 

  52. Klauke S, Goertz M, Rein S, Hoehl D, Thomas U, Eckhorn R, et al. Stimulation with a wireless intraocular epiretinal implant elicits visual percepts in blind humans. Invest Ophthalmol Vis Sci. 2011;52(1):449–55.

    Article  PubMed  Google Scholar 

  53. Menzel-Severing J, Laube T, Brockmann C, Bornfeld N, Mokwa W, Mazinani B, et al. Implantation and explantation of an active epiretinal visual prosthesis: 2-year follow-up data from the EPIRET3 prospective clinical trial. Eye (Lond). 2012;26(4):501–9.

    Article  CAS  Google Scholar 

  54. Rizzo JF 3rd. Update on retinal prosthetic research: the Boston retinal implant project. J Neuroophthalmol. 2011;31(2):160–8.

    Article  PubMed  Google Scholar 

  55. Lorach H, Goetz G, Smith R, Lei X, Mandel Y, Kamins T, et al. Photovoltaic restoration of sight with high visual acuity. Nat Med. 2015;21(5):476–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Zrenner E, Bartz-Schmidt KU, Benav H, Besch D, Bruckmann A, Gabel VP, et al. Subretinal electronic chips allow blind patients to read letters and combine them to words. Proc Biol Sci. 2011;278(1711):1489–97.

    Article  PubMed  Google Scholar 

  57. Kitiratschky VB, Stingl K, Wilhelm B, Peters T, Besch D, Sachs H, et al. Safety evaluation of “retina implant alpha IMS” - a prospective clinical trial. Graefes Arch Clin Exp Ophthalmol. 2015;253(3):381–7.

    Article  PubMed  Google Scholar 

  58. Wang L, Mathieson K, Kamins TI, Loudin JD, Galambos L, Goetz G, et al. Photovoltaic retinal prosthesis: implant fabrication and performance. J Neural Eng. 2012;9(4):046014.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Kanda H, Morimoto T, Fujikado T, Tano Y, Fukuda Y, Sawai H. Electrophysiological studies of the feasibility of suprachoroidal-transretinal stimulation for artificial vision in normal and RCS rats. Invest Ophthalmol Vis Sci. 2004;45(2):560–6.

    Article  PubMed  Google Scholar 

  60. Ayton LN, Blamey PJ, Guymer RH, Luu CD, Nayagam DA, Sinclair NC, et al. First-in-human trial of a novel suprachoroidal retinal prosthesis. PLoS One. 2014;9(12):e115239.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  61. Sakaguchi H, Kamei M, Fujikado T, Yonezawa E, Ozawa M, Cecilia-Gonzalez C, et al. Artificial vision by direct optic nerve electrode (AV-DONE) implantation in a blind patient with retinitis pigmentosa. J Artif Organs. 2009;12:206–9.

    Article  PubMed  Google Scholar 

  62. Brelén ME, Vince V, Gérard B, Veraart C, Delbeke J. Measurement of evoked potentials after electrical stimulation of the human optic nerve. Invest Opthalmol Vis Sci. 2010;51(10):5351–5.

    Article  Google Scholar 

  63. Delbeke J. Electrodes and chronic optic nerve stimulation. Biocybern Biomed Eng. 2011;31(3):81–94.

    Article  Google Scholar 

  64. Veraart C, Raftopoulos C, Mortimer JT, Delbeke J, Pins D, Michaux G, et al. Visual sensations produced by optic nerve stimulation using an implanted self-sizing spiral cuff electrode. Brain Res. 1998;813(1):181–6.

    Article  CAS  PubMed  Google Scholar 

  65. Veraart C, Wanet-Defalque MC, Gérard B, Vanlierde A, Delbeke J. Pattern recognition with the optic nerve visual. Artif Organs. 2003;27(11):996–1004.

    Article  PubMed  Google Scholar 

  66. Brelén ME, De Potter P, Gersdorff M, Cosnard G, Veraart C, Delbeke J. Intraorbital implantation of a stimulating electrode for an optic nerve visual prosthesis. J Neurosurg. 2006;104(4):593–7.

    Article  PubMed  Google Scholar 

  67. Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, et al. Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes. Jpn J Ophthalmol. 2004;48:552–7.

    Article  PubMed  Google Scholar 

  68. Sakaguchi H, Kamei M, Nishida K, Terasawa Y, Fujikado T, Ozawa M, et al. Implantation of a newly developed direct optic nerve electrode device for artificial vision in rabbits. J Artif Organs. 2012;15(3):295–300.

    Article  PubMed  Google Scholar 

  69. Pezaris JS, Reid RC. Demonstration of artificial visual percepts generated through thalamic microstimulation. Proc Natl Acad Sci U S A. 2007;104(18):7670–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Panetsos F, Sanchez-Jimenez A, De CED, Diaz-Guemes I, Sanchez FM. Consistent phosphenes generated by electrical microstimulation of the visual thalamus. An experimental approach for thalamic visual neuroprostheses. Front Neurosci. 2011;5:84.

    Article  PubMed  PubMed Central  Google Scholar 

  71. Dobelle WH. Artificial vision for the blind by connecting a television camera to the visual cortex. ASAIO J. 2000;46(1):3–9.

    Article  CAS  PubMed  Google Scholar 

  72. Schmidt EM, Bak MJ, Hambrecht FT, Kufta CV, O’Rourke DK, Vallabhanath P. Feasibility of a visual prosthesis for the blind based on intracortical microstimulation of the visual cortex. Brain. 1996;119(Pt 2):507–22.

    Article  PubMed  Google Scholar 

  73. Dobelle WH, Mladejovsky MG. Phosphenes produced by electrical stimulation of human occipital cortex and their application to the development of a prosthesis for the blind. J Physiol. 1974;243(2):553–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Business Wire. Second sight receives conditional FDA approval to begin first orion human clinical study. 2017.

  75. Coulombe J, Sawan M. Gervais JF. A highly flexible system for microstimulation of the visual cortex: design and implementation. IEEE Trans Biomed Circuits Syst. 2007;1(4):258–69.

    Article  CAS  PubMed  Google Scholar 

  76. Pelayo FJ, Martinez A, Romero S, Morillas CA, Ros E, Fernandez E. Cortical visual neuro-prosthesis for the blind: retina-like software/hardware preprocessor. In: IEEE/EMBS Conf neural Eng NER1; 2003.

    Google Scholar 

  77. Lowery J. Introducing the monash vision group’s cortical prosthesis. In: IEEE International Conference on Image Processing 2013.

  78. Tawakol O, Bredeson SD, Troyk PR. Preparation of a neural electrode implantation device for invivo surgical use. In: 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2016.

  79. Troyk PR. The intracortical visual prosthesis project. In: Gabel V, editor. Artificial Vision, springer, Cham; 2017. p. 203–14.

    Chapter  Google Scholar 

  80. Bach-y-Rita P, Kaczmarek KA, Tyler ME, Garcia-Lara J. From perception with a 49-point electrotactile stimulus array on the tongue: a technical note. J Rehabil Res Dev. 1998;35(4):427–30.

    CAS  PubMed  Google Scholar 

  81. Meijer PBL. An experimental system for auditory image representations[J]. IEEE Trans Biomed Eng. 1992;39(2):112–21.

    Article  CAS  PubMed  Google Scholar 

Download references


Not applicable.


This work was supported by the William M. Wood Foundation. The funding agency had no influence over the content of this report.

Availability of data and materials

Not applicable.

Author information

Authors and Affiliations



RMM performed the literature review and wrote the paper. JSP helped with the review and writing of the paper. Both authors read and approved the final manuscript.

Corresponding author

Correspondence to John S. Pezaris.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Rights and permissions

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mirochnik, R.M., Pezaris, J.S. Contemporary approaches to visual prostheses. Military Med Res 6, 19 (2019).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: