Fig. 2
Comparison of mouse models and human prostate tissues at anatomical structure, cellular configuration and cellular marker levels. a The mouse prostate can be divided into: anterior lobe, ventral lobe and dorsolateral lobe and the human prostate can be divided into: peripheral zone, transitional zone and central zone. b The prostates of both mice and humans are composed of pseudostratified epithelia and stromal cells. Pseudostratified epithelium consists of three types of cells: luminal cells, neuroendocrine cells, and basal cells. Stromal cells are further categorized into autonomic nerve fibers, immune cells, smooth muscle cells, fibroblasts, and endothelial cells. c The cellular markers of basal cell contain CK5, CK14 and p63. The cellular markers of luminal cell contain CK8, CK18 and NKX3.1. The cellular markers of neuroendocrine cell contain chromogranin A and synaptophysin. CK cytokeratin