Fig. 8From: Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosisThe pretreatment with IFN-α induces the activation of DHX58, which recruits YTHDC2 to recognize and enhance the translation of m6A-modified Gpx4 mRNA, thus preventing hepatic ferroptosis. IFN-α interferon-α, DHX58 DExH-box helicase 58, GPX4 glutathione peroxidase 4, ROS reactive oxygen species, YTHDC2 YT521-B homology domain containing 2, m6A N6-methyladenosineBack to article page