Table 6 Application of immune cell-based DDS in MS, depression, and epilepsy
From: Immune cells: potential carriers or agents for drug delivery to the central nervous system
Immune cells | Components | Loaded drugs | Methods | Model | Functions | References |
|---|---|---|---|---|---|---|
T cell | Cell | NBR functioned with an anti-CD20 monoclonal antibody | Trojan horse | Experimental autoimmune encephalomyelitis | Deplete B cells in the spleen and the brain Ameliorates the disease course and pathology | [223] |
Monocyte | Cell | cRGD-modified liposome | Trojan horse | IL-1β-induced brain inflammatory model mice The CMS-induced depression model mice | Target basolateral amygdala regions Antidepressant | [225] |
Monocyte | Cell | Polylactic acid-based magnetite-impregnated MNPs | Trojan horse | Spontaneous recurrent seizures model rats | Target the hippocampal CA1 and dentate gyrus | [226] |