Table 5 Application of immune cells DDS applied in PD
From: Immune cells: potential carriers or agents for drug delivery to the central nervous system
Immune cells | Components | Loaded drugs/nanoparticles | Methods | Model | Functions | References |
|---|---|---|---|---|---|---|
Macrophage | Cell | Catalase/PEI-PEG complexes | Trojan horse | MPTP-intoxicated mice BBB model in vitro | Target affected brain subregions in models of PD and transport the loaded drug from macrophages to endothelial, neuronal, and glial target cells Reduce oxidative stress Reductions microglial activation and astrocytosis Increase survival of dopaminergic neurons and nigrostriatal NAA levels | |
| Â | Cell | Catalase pDNA | Gene transfection | 6-OHDA or LPS-induced brain inflammation model | Target BBB and transfer the loaded drug to neural cells Reduce inflammation Increase neuroprotection Improve motor functions | [210] |
| Â | Cell | GDNF | Gene transfection | MPTP-intoxicated mice MitoPark mouse 6-OHDA-intoxicated mice Transgenic Parkin Q311X(A) mice | Ameliorate neurodegeneration and neuroinflammation Stimulate axon regeneration Diminish alpha-synuclein aggregation Increase survival of dopaminergic neurons Improve motor and non-motor dysfunction | |
Bone marrow-derived-microglia | Cell | Neurturin | Lentiviral transduction | MPTP-intoxicated mice | Protect dopaminergic neurons Ameliorate neurodegeneration and dopaminergic injury Improve motor dysfunction | [217] |
Macrophage | Exosomes | GDNF | Gene transfection and differential centrifugation | Transgenic Parkin Q311(X)A mice | Improve mobility Increase neuronal survival Decrease neuroinflammation | [216] |
Macrophage | Exosomes | Catalase | Differential centrifugation and filtration; incubation at RT with or without saponin Freeze/thaw cycles technique Sonication Extrusion | 6-OHDA-intoxicated mice | Target neuronal cells Protect substantia nigra neurons against oxidative stress | [218] |
Macrophage | Nanovesicles | Curcumin | Recycled exclusion and sonication | MPP+-induced neuronal degeneration model | Target BBB and neurons Ameliorate neurodegeneration | [219] |