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Fig. 8 | Military Medical Research

Fig. 8

From: Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss

Fig. 8

Proposed working model of how to target vulnerable microcircuits in the ventral hippocampus to ameliorate Alzheimer-like social memory loss. Proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1 (vCA1) under both physiological conditions and in the presence of AD-like tau pathology. Excitatory and PV neurons in the vCA1 are vulnerable to tau accumulation. Accumulated tau suppresses excitability and disrupts the firing patterns of excitatory and PV neurons, impairing social memory. Intragastric administration of UA efficiently promoted autophagy to reduce the accumulation of tau and improve social memory in a TFEB-dependent manner. vCA1 ventral hippocampal CA1, PV parvalbumin, TFEB transcription factor EB, UA ursolic acid, AD alzheimer’s disease

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Military Medical Research

ISSN: 2054-9369