Fig. 6

Photoactivation of excitatory and PV neurons rescues tau accumulation-impaired discrimination in social memory. Schematic of stimulation while vCA1-hTau mice were investigating familiar (a) and novel (c) conspecifics in the social memory test. b When vCA1-hTau^CaMKII mice were exploring a familiar mouse, photoactivation of excitatory neurons in the vCA1 significantly increased the preference for the novel mouse and concurrently raised the discrimination score. n = 9 per group. d Photostimulation of PV neurons in the vCA1 at 40 Hz, as in which vCA1-hTau^PV mice were exposed a novel mouse, efficiently increased the social interaction time with the novel mouse and increased the discrimination score. n = 8 per group. ^**P < 0.01, as determined by two-way ANOVA or two-tailed unpaired t test. The data are expressed as the mean ± SEM. CaMKII calcium/calmodulin-dependent protein kinase II, PV parvalbumin, vCA1 ventral hippocampal CA1, eYFP enhanced yellow fluorescent protein, ChR2 channelrhodopsins-2