Fig. 5

vCA1-hTau^PV accumulation disinhibits excitatory neurons during novel conspecific identification. a Schematic of GABA signal recording in the social memory test. b Representative image of iGABASnFR and hTau expression in the vCA1 of PV-Cre mice. Scale bar = 100 μm. c Representative trace of GABA signals. d Per-bout stacked plots of GABA signals on CaMKII⁺ neurons aligned to the start of the interaction event. The presence of “#” indicates a significant increase in the average GABA signals during the social exploration period (the first 2 s) compared to those during the baseline period (2 s before social exploration). e Quantitative analysis of peak dF/F of GABA signals into CaMKII⁺ neurons during social memory test. f Schematic of Ca²⁺ signal recording in the social memory test. g Representative image of GCaMP6f and hTau expression in the vCA1 of PV-Cre mice. Scale bar = 100 μm. h Representative trace of GCaMP6f signals. i Per-bout stacked plots of GCaMP6f signals of CaMKII⁺ neurons aligned to the start of the interaction event. The presence of “#” indicates a significant increase in the average calcium signals during the social exploration period (the first 2 s) compared to those during the baseline period (2 s before social exploration). j Quantitative analysis of peak dF/F of Ca²⁺ signals in CaMKII⁺ neurons during the social memory test. n = 6 per group. ^*P < 0.05; ^**P < 0.01 as determined by two-way ANOVA or two-tailed paired t test. The data are presented as the mean ± SEM. CaMKII calcium/calmodulin-dependent protein kinase II, PV parvalbumin, vCA1 ventral hippocampal CA1, iGABASnFR intensity-based GABA-sensing fluorescence reporters, GCaMP6f genetically encoded calcium indicators