Fig. 5
From: Regulatory T cells in skin regeneration and wound healing
Regulatory T cells (Tregs) in keloid scarring. Tregs can downregulate the expression and cellular impact of TGF-β to target excessive matrix deposition as a hallmark of keloid scarring. Tregs can further reduce mRNA expression of type I collagen. Excessive collagen I and fibrin accumulations have been implicated with fibrosis as part of keloid formation. IL-10 interleukin-10, IL6R interleukin-6 receptor, TGFβR tumor growth factor beta receptor, α-SMA α-smooth muscle actin