Fig. 4
From: Regulatory T cells in skin regeneration and wound healing
Cellular cross-talks of regulatory T cells (Tregs) in the skin. In response to UVB radiation, Tregs secrete amphiregulin and enkephalin which bind to EGFR receptors and promote keratinocyte outgrowth. Tregs can suppress T effector cells (Teff) and M1 macrophages, as well as hinder the differentiation of M1 macrophages into M2 macrophages. Tregs can also secrete IL-10 hindering the extravasation of neutrophils and the production of proinflammatory cytokines such as TNF-α and IL-6. EGFR epidermal growth factor receptor, IFN interferon, IL-1β interleukin-1β, TNF tumor necrosis factor, UVB ultraviolet B, Mφ macrophage