Fig. 6

Construction process and the structure of representative ROS-responsive hydrogels. a The formation and mechanism of a PVA-based hydrogel cross-linked with an ROS-responsive linker loaded with therapeutics for the treatment of wounds with bacterial infection. Reproduced with permission [25]. Copyright 2020, Elsevier. b Schematic synthesis of ROS-responsive hydrogel PPBA-TA-PVA and its anti-inflammatory mechanism in diabetic wound sites. Reproduced with permission [93]. Copyright 2022, American Chemical Society. COL-1 collagen-1, COL-3 collagen-3, GM-CSF granulocyte-macrophage colony-stimulating factor, IL-1β interleukin-1β, IL-6 interleukin-6, PPBA phenylboric acid-modified polyphosphazene, PVA polyvinyl alcohol, ROS reactive oxygen species, S.a.u Staphylococcus aureus, TNF-α tumor necrosis factor-α, TA tannic acid, TPA N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-tetramethylpropane-1, 3-diaminium, TGF-β1 transforming growth factor beta 1