Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus

Table 8 The influence of the flow variation of carbonate replacement fluid on net alkali load at a specific 4% TSC flow rate

Replacement fluid flow rate corresponding to the requirement for alkali replenishment		Alkali supplements provided by RCA		Difference between alkali provided by RCA and alkali required^* (ml/h)
Replacement liquid A (ml/h)	Replacement liquid B (non-citrate anticoagulation) (ml/h)	4% TSC (ml/h)	Equivalent to supplementing alkali (ml/h)
0	0	200	137	+ 137
1000	63	200	137	+ 74
1500	94	200	137	+ 43
2000	125	200	137	+ 12
2500	156	200	137	− 19
3000	188	200	137	− 51

This table is a mathematical simulation at a 4% TSC flow rate of 200 ml/h, in which the “alkali” flow rate is converted to 5% NaHCO₃ (ml/h); Net alkali load = alkali replenishment demand subtracted by alkali produced by citrate metabolism (ml/h). For more information on the composition and concentration of replacement fluids A and B, please refer to Additional file 1. RCA regional citrate anticoagulation; TSC trisodium citrate; ^*alkali excess when + ; alkali needed when -

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