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Table 3 Relationship between the flow rates of citrate and blood

From: Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus

When the blood flow rate is 150 ml/min, hourly conversion is 9000 ml/h (= 9.0 L/h)

Target blood concentration of citrate

3 mmol/L

4 mmol/L

Required amount of citrate

3 × 9.0 = 27.0 mmol/h

4 × 9.0 = 36.0 mmol/h

3% ACD-A solution (113 mmol/L)

27.0/113 = 0.239 L/h ≈ 240 ml/h

36.0/113 = 0.319 L/h ≈ 320 ml/h

4% TSC solution (136 mmol/L)

27.0/136 = 0.198 L/h ≈ 200 ml/h

36.0/136 = 0.264 L/h ≈ 260 ml/h

  1. To achieve the ideal anticoagulant strength, the ratio of 3% ACD-A solution to blood flow is about 1.60–2.13 (ml/h vs. ml/min); the ratio of 4% TSC solution to blood flow is about 1.33–1.73 (ml/h vs. ml/min). ACD-A citrate-glucose anticoagulant A, TSC trisodium citrate