Fig. 2

Application of cryo-EM in structure-based drug design (SBDD). a Schematic diagram of SBDD technology. b, c Cartoon display of cryo-EM structure of GLP-1R bound with small molecule PF-06883365 and PF-06882961 at 3.8 Å and 2.5 Å resolution, respectively (PDB: 7S15. EMDB: EMD-24794 for PF-06883365 bound state. PDB: 6X1A. EMDB: EMD-21994 for PF-06882961 bound state). The panel shows the map density of the ligand and the key residues for the binding of the agonist. GLP-1R glucagon-like peptide-1 receptor