Fig. 7

Relationship between periodic transcripts and chemotherapeutic drug sensitivity. a Heatmap listing the top 10 transcripts with the highest positive (ENST00000260526, ENST00000388835, ENST00000295522, ENST00000367815, ENST00000306442, ENST00000592688, ENST00000371610, ENST00000422847, ENST00000252483, and ENST00000519106) and negative (ENST00000216468, ENST00000361204, ENST00000462885, ENST00000340648, ENST00000320676, ENST00000585124, ENST00000375436, ENST00000391857, ENST00000339399, and ENST00000398665) correlations with sensitivity to docetaxel, paclitaxel, vinblastine, vincristine and vinorelbine. Line graphs showing the periodic expression patterns of the transcripts in HeLa, HCT116 and MDA-MB-231 cells are also shown. b Correlations of DPM2 and ENST00000314392 with sensitivity to docetaxel, paclitaxel, vincristine and vinorelbine. c Periodic expression of DPM2 and ENST00000314392 in HeLa cells. d Periodic expression of DPM2 and ENST00000314392 in MDA-MB-231 cells. ARHGAP29 rho-type GTPase-activating protein 29, KRT18 keratin 18, CLDN claudin, ATP1B1 ATPase Na⁺/K⁺ transporting subunit beta 1, PPIC peptidyl-prolyl cis–trans isomerase C, MYO5B myosin VB, PARD6B partitioning defective 6 homolog beta, LINC00857 long intergenic non-protein coding RNA 857, NECTIN2 nectin cell adhesion molecule 2, TMED8 transmembrane P24 trafficking protein family member 8, SREBF2 sterol regulatory element binding transcription factor 2, RPL18AP3 ribosomal protein L18a pseudogene 3, RRP1B ribosomal RNA processing 1B, RBMX RNA binding motif protein X-linked, AURKB aurora kinase B, RCC2 regulator of chromosome condensation 2, RPL13A ribosomal protein L13a, ANP32B acidic nuclear phosphoprotein 32 family member B, DOT1L DOT1 like histone lysine methyltransferase, DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2