Table 1 Demographic and clinical data of amisulpride and placebo groups at baseline
Item | Amisulpride (n = 40) | Placebo (n = 40) | X2 or F(P) | Dropouts (n = 9) | Completers (n = 71) | X2 or F(P) |
|---|---|---|---|---|---|---|
Age (years, mean ± SD) | 46.60 ± 9.36 | 47.95 ± 7.20 | 0.52 (0.48) | 45.33 ± 4.80 | 47.52 ± 8.67 | 0.54 (0.46) |
Sex (n, male/female) | 19/21 | 22/18 | 0.45 (0.50) | 4/5 | 36/35 | 0.08 (0.78) |
BMI (kg/m2, mean ± SD) | 24.76 ± 3.47 | 23.06 ± 2.84 | 4.85 (0.03) | 23.00 ± 0.99 | 24.02 ± 3.43 | 1.05 (0.31) |
Education (years, mean ± SD) | 11.48 ± 2.46 | 11.10 ± 2.26 | 0.27 (0.61) | 10.78 ± 1.48 | 11.35 ± 2.44 | 0.75 (0.39) |
Age of onset (years, mean ± SD) | 22.70 ± 5.32 | 23.45 ± 6.26 | 0.26 (0.60) | 23.89 ± 4.37 | 22.97 ± 5.95 | 0.38 (0.54) |
Illness duration (years, mean ± SD) | 23.05 ± 5.65 | 23.73 ± 6.45 | 0.19 (0.66) | 24.38 ± 4.52 | 23.26 ± 6.22 | 0.39 (0.54) |
Clozapine dose (mg/d, mean ± SD) | 438.75 ± 32.99 | 447.50 ± 37.47 | 1.21 (0.28) | 441.67 ± 30.62 | 443.31 ± 36.10 | 0.07 (0.80) |
Serum clozapine level (ng/ml, mean ± SD) | 478.05 ± 81.17 | 491.05 ± 80.17 | 0.56 (0.46) | 484.11 ± 61.17 | 484.61 ± 82.90 | 0.01 (0.91) |
PANSS total score (mean ± SD) | 82.28 ± 8.54 | 79.53 ± 6.71 | 2.59 (0.11) | 79.44 ± 4.33 | 81.08 ± 8.09 | 0.41 (0.53) |
  P subscore | 19.40 ± 6.54 | 20.73 ± 3.90 | 1.44 (0.23) | 19.11 ± 4.11 | 20.18 ± 5.54 | 0.30 (0.59) |
  N subscore | 21.15 ± 7.45 | 18.98 ± 4.69 | 2.86 (0.10) | 21.78 ± 4.21 | 19.85 ± 6.49 | 0.94 (0.34) |
  G subscore | 41.50 ± 6.33 | 39.83 ± 3.55 | 2.17 (0.15) | 38.67 ± 3.71 | 40.92 ± 5.29 | 1.91 (0.17) |
RBANS total score (mean ± SD) | 59.38 ± 7.71 | 60.28 ± 10.14 | 0.23 (0.64) | 59.44 ± 5.73 | 59.87 ± 9.32 | 0.02 (0.89) |
  Immediate memory | 59.43 ± 9.65 | 59.83 ± 10.68 | 0.05 (0.83) | 60.33 ± 3.35 | 59.54 ± 11.25 | 0.04 (0.83) |
  Visuospatial/construction | 67.50 ± 12.23 | 68.65 ± 11.97 | 0.11 (0.74) | 68.11 ± 5.18 | 68.07 ± 12.67 | 0.001 (0.98) |
  Language | 71.15 ± 14.02 | 71.63 ± 13.86 | 0.08 (0.78) | 70.22 ± 5.87 | 71.54 ± 14.58 | 0.07 (0.79) |
  Attention | 73.65 ± 9.68 | 73.75 ± 11.52 | 0.26 (0.61) | 72.89 ± 5.13 | 73.80 ± 11.41 | 0.04 (0.84) |
  Delayed memory | 57.93 ± 7.71 | 61.03 ± 10.14 | 1.52 (0.22) | 59.00 ± 6.93 | 59.54 ± 10.11 | 0.02 (0.89) |
SANS (mean ± SD) | 45.18 ± 15.38 | 43.13 ± 14.36 | 0.36 (0.55) | 42.56 ± 6.80 | 44.38 ± 11.53 | 0.12 (0.73) |
CGI-S (mean ± SD) | 5.03 ± 0.70 | 4.90 ± 0.71 | 0.49 (0.49) | 5.11 ± 0.78 | 4.94 ± 0.70 | 0.42 (0.52) |
CGI-I (mean ± SD) | 4.06 ± 0.22 | 4.03 ± 0.16 | 0.17 (0.68) | 4.11 ± 0.33 | 4.03 ± 0.17 | 1.30 (0.26) |
CGI-E (mean ± SD) | 13.60 ± 0.50 | 13.58 ± 0.50 | 0.34 (0.56) | 13.44 ± 0.53 | 13.61 ± 0.49 | 0.59 (0.45) |