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Fig. 10 | Military Medical Research

Fig. 10

From: Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo

Fig. 10

UTMD enhanced the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy. UTMD improved the response of glioblastoma cells to IR via the proposed signaling pathways: UTMD downregulates PGRMC1 expression, thereby inhibiting the combination of PGRMC1 with LC3B2, which is followed by a decrease of autophagosome-lysosome fusion, subsequently disrupting autophagic degradation and ultimately enhancing the radiosensitivity of glioblastoma. IR ionizing radiation, UTMD ultrasound-triggered microbubble destruction, PGRMC1 progesterone receptor membrane component 1, LC3B light chain 3 beta

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Military Medical Research

ISSN: 2054-9369