Military traumatic brain injury: a challenge straddling neurology and psychiatry

Table 1 Pathological similarities and differences between TBI and other neurodegenerative diseases

Diseases	Abnormal p-Tau	Aβ Plaque formation	TDP-43 deposits	α-synuclein deposits
TBI/CTE	√	√	√	√
AD	√	√	√
FTD/FTLD			√
Others*			√	√

In the above studies, the subjects were not limited to military personnel, so the possibility of negative results in the population of military TBI patients cannot be ruled out
TBI traumatic brain injury, CTE chronic traumatic encephalopathy, AD Alzheimer's disease, FTD frontotemporal dementia, FTLD frontotemporal lobe degeneration, p-Tau phosphorylated Tau protein, Aβ amyloid-β, TDP-43 trans-reaction DNA-binding protein 43 kD
^*Includes other neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis

ISSN: 2054-9369