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Table 1 Pathological similarities and differences between TBI and other neurodegenerative diseases

From: Military traumatic brain injury: a challenge straddling neurology and psychiatry

Diseases Abnormal p-Tau Aβ Plaque formation TDP-43 deposits α-synuclein deposits
TBI/CTE
AD  
FTD/FTLD     
Others*   
  1. In the above studies, the subjects were not limited to military personnel, so the possibility of negative results in the population of military TBI patients cannot be ruled out
  2. TBI traumatic brain injury, CTE chronic traumatic encephalopathy, AD Alzheimer's disease, FTD frontotemporal dementia, FTLD frontotemporal lobe degeneration, p-Tau phosphorylated Tau protein, amyloid-β, TDP-43 trans-reaction DNA-binding protein 43 kD
  3. *Includes other neurodegenerative diseases such as Parkinson's disease and amyotrophic lateral sclerosis