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Fig. 7 | Military Medical Research

Fig. 7

From: Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood–brain barrier injury through the Wnt/β-catenin signalling pathway

Fig. 7

Silencing of β-catenin aggravated downregulation of the occludin, claudin-1 and ZO-1 proteins, and reduced the proliferation and migration of RBMVECs following OGD/R. a Western blotting showed that Si1 was the most effective siRNA for silencing endogenous β-catenin gene expression. &P < 0.001, compared with the NC group; *P < 0.001, compared with the Si3 group; #P < 0.001, compared with the Si2 group. b Representative Western blotting images of occludin, claudin-1 and ZO-1 proteins in RBMVECs in each group. c Cell scratch test showed that proliferation and migration repair ability of RBMVECs in each group. All scale bars = 250 µm. Data are presented as the mean ± standard deviation (SD) from three independent experiments. *P < 0.001, compared with the normal group; #P < 0.001, compared with the control-siRNA group. NC group negative control group; OGD/R oxygen–glucose deprivation and reoxygenation; RBMVECs rat brain microvascular endothelial cells

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Military Medical Research

ISSN: 2054-9369