Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study

Table 2 Clinical outcomes of the study patients with different fluid balance trajectory patterns

Characteristics	All (n = 986)	Fluid balance trajectory patterns			P
Characteristics	All (n = 986)	Decreasing FB (n = 64)	Low FB (n = 841)	High FB (n = 81)	P
Clinical outcomes [n (%)]
Hospital mortality	430 (43.6)	30 (46.9)	342 (40.7)	58 (71.6)^§	< 0.001
Organ dysfunction	613 (62.2)	30 (46.9)	519 (61.7)	64 (79.0)^§	< 0.001
MAKE	499 (50.6)	33 (51.6)	399 (47.4)^§	67 (82.7)^§	< 0.001
SRAE	373 (37.8)	19 (29.7)	307 (36.5)	47 (58.0)^§	0.014
Length of stay [d, M (IQR)]
Hospital^*	20.0 (12.0–30.0)	21.0 (13.0–31.0)	19.0 (12.0–30.0)	20.0 (8.0–35.0)	0.576
ICU^*	10.0 (5.0–16.0)	12.0 (8.0–17.0)	10.0 (5.0–16.0)	9.0 (4.0–23.0)	0.128

FB fluid balance, IQR interquartile range, MAKE major adverse kidney events, SRAE severe respiratory adverse events, ^*For survivors; ^§Compared with decreasing FB, P < 0.05

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