Chinese expert consensus on diagnosis and treatment of trauma-induced hypercoagulopathy

Table 1 Thrombophilia testing

Classification	Disease	Workup
Hereditary thrombophilia	AT deficiency	AT activity, antigen
	Protein C deficiency	Protein activity, antigen
	Protein S deficiency	Protein S activity, Free protein S antigen
	Prothrombin G20210A	Genetic testing
	APC resistance	Activated protein C resistance test, Genetic testing
Acquired thrombophilia	APLS	clinical, vascular thrombosis and/or pregnancy morbidity; laboratory, 1 of the following on ≥2 occasions at least 12 weeks apart: IgG or IgM anti-cardiolipin antibodies (>40 U); IgG or IgM anti-β2-glycoprotein I antibodies (> 40 U); LA
	PNH	CBC, haptoglobin, LDH, total/direct bilirubin, iron studies, urinalysis, peripheral blood flow cytometry
	Malignant tumor, SLE, nephrotic syndrome, collagen angiopathy, inflammatory bowel disease, obesity	History, physical examination, blood and urine routine examination, hepatic and renal functions, chest radiograph, tumor screening
	Myeloproliferative neoplasm	Mutation analysis for JAK2, calreticulin and thrombopoietin receptor MPL

AT antithrombin, APC activated protein C, APLS antiphospholipid antibody syndrome, CBC complete blood count, LA lupus anticoagulant, LDH lactate dehydrogenase, PNH paroxysmal nocturnal hemoglobinuria, SLE systemic lupus erythematosus, JAK janus kinase

ISSN: 2054-9369