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Table 3 Univariate and multivariate COX proportional hazards regression analysis of death in the training cohort

From: Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study

Variable Univariate Multivariate
HR (95% CI) P HR (95% CI) P
Age (≥70 years vs. < 70 years) 9.245 (2.054–11.624) 0.004 1.184 (1.061–1.321) 0.003
Gender (male vs. female) 1.495 (0.577–3.874) 0.407
Comorbidity   
Without comorbidity 1   1  
With single comorbidity 3.625 (0.639–4.503) 0.120 1.810 (0.794–2.585) 0.551
With multiple comorbidity 2.250 (1.407–4.947) 0.022 1.155 (0.831–3.130) 0.479
Smoke (yes vs. no) 1.309 (0.533–3.212) 0.556
Panting (breathing rate ≥ 30/min) (yes vs. no) 5.492 (2.876–7.078) 0.002 3.300 (2.509–6.286) 0.004
WBC (> 10 × 109/L vs. ≤ 10 × 109/L) 5.238 (1.906–9.397) 0.001 2.046 (0.726–4.503) 0.524
Lymphocyte (< 1.0 × 109/L vs. ≥ 1.0 × 109/L) 5.263 (2.513–9.615) 0.002 2.283 (1.779–3.267) 0.011
Neutrophil (> 6.3 × 109/L vs. ≤ 6.3 × 109/L) 4.961 (1.884–8.068) 0.001 2.439 (0.717–3.768) 0.392
PLT (≥ 100 × 109/L vs. < 100 × 109/L) 3.556 (0.911–6.876) 0.068
CRP (> 10 mg/L vs. ≤ 10 mg/L) 4.327 (1.369–7.677) 0.013 1.214 (0.721–2.211) 0.196
D-dimer (> 0.55 mg/L vs. ≤ 0.55 mg/L) 6.721 (1.490–9.319) 0.013 1.395 (0.668–3.268) 0.195
PCT (> 0.05 ng/ml vs. ≤ 0.05 ng/ml) 3.224 (1.154–6.645) 0.032 2.255 (0.768–4.767) 0.118
IL-6 (> 10 pg/ml vs. ≤ 10 pg/ml) 4.547 (3.184–8.659) 0.002 3.029 (1.567–7.116) 0.009
SaO2 on admission(≥ 90% vs. < 90%) 1.662 (0.739–2.007) 0.180
TBIL (≥ 20 μmol/L vs. < 20 μmol/L) 1.595 (0.627–2.057) 0.327
ALT (≥ 40 U/L vs. < 40 U/L) 2.024 (0.775–5.283) 0.150
AST (≥ 40 U/L vs. < 40 U/L) 1.909 (0.746–4.883) 0.177
LDH (≥ 245 U/L vs. < 245 U/L) 1.923 (0.739–5.007) 0.180
γ-GT (≥ 50 U/L vs. < 50 U/L) 1.444 (0.567–3.677) 0.440
Cr (> 80 μmol/L vs. ≤ 80 μmol/L) 1.195 (0.456–3.129) 0.717
  1. WBC White blood cell, PLT Platelet, CRP C-reactive protein, PCT Procalcitonin, IL-6 Interleukin-6, SaO2 Oxygen saturation, TBIL Total bilirubin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, LDH Lactate dehydrogenase, γ-GT γ-glutamyl transpeptadase, Cr Creatinine, HR Hazard ratio, 95% CI 95% confidence interval