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Table 1 Comparison of baseline characteristics between patients in training and validation cohorts [n(%)]

From: Nomogram for prediction of fatal outcome in patients with severe COVID-19: a multicenter study

Variables Training cohort (n = 124) Validation cohort 1 (n = 71) Validation cohort 2 (n = 76) P
Age (year) 0.001
  ≥ 70 73 (58.9) 25 (35.2) 29 (38.2)  
  < 70 51 (41.1) 46 (64.8) 47 (61.8)  
Gender
 Male 69 (55.7) 42 (59.2) 41 (54.0) 0.810
Comorbidity 0.291
 Without comorbidity 31 (25.0) 27 (38.0) 26 (34.2)  
 With single comorbidity 38 (30.7) 16 (22.6) 21 (27.6)  
 With multiple comorbidity 55 (44.3) 28 (39.4) 29 (38.2)  
 Smoke 66 (53.2) 16 (22.5) 19 (25.0) < 0.001
 Panting (breathing rate ≥ 30/min) 56 (45.2) 63 (88.7) 67 (88.2) < 0.001
WBC (×109/L) 0.005
  >  10 24 (19.4) 29 (40.9) 20 (26.3)  
  ≤ 10 100 (80.6) 42 (59.1) 56 (73.7)  
Lymphocyte (×109/L) 0.352
  > 1.0 56 (45.2) 28 (39.4) 39 (51.3)  
  ≤ 1.0 68 (54.8) 43 (60.6) 37 (48.7)  
Neutrophil (×109/L) 0.013
  >  6.3 36 (29.0) 35 (49.3) 24 (31.6)  
  ≤ 6.3 88 (71.0) 36 (50.7) 52 (68.4)  
PLT (×109/L) 0.346
  ≥ 100 114 (91.9) 61 (85.9) 70 (92.1)  
  <  100 10 (8.1) 10 (14.1) 6 (7.9)  
CRP (mg/L) 0.026
  >  10 70 (56.5) 36 (50.7) 28 (36.8)  
  ≤ 10 54 (43.5) 35 (49.3) 48 (63.2)  
D-dimer (mg/L) 0.992
  >  0.55 81 (65.3) 46 (64.8) 50 (65.8)  
  ≤ 0.55 43 (34.7) 25 (35.2) 26 (34.2)  
PCT (ng/ml) 0.312
  > 0.05 87 (70.2) 57 (80.3) 56 (73.7)  
  ≤ 0.05 37 (29.8) 14 (19.7) 20 (26.3)  
IL-6 (pg/ml) 0.298
  ≥ 10 68 (54.8) 47 (66.2) 44 (57.9)  
  <  10 56 (45.2) 24 (33.8) 32 (42.1)  
SaO2 on admission < 0.001
  ≥ 90% 85 (68.6) 18 (25.4) 34 (44.7)  
  <  90% 39 (31.4) 53 (74.6) 42 (55.3)  
TBIL (μmol/L) 0.098
  ≥ 20 45 (36.3) 16 (22.5) 28 (36.8)  
  <  20 79 (63.7) 55 (77.5) 48 (63.2)  
ALT (U/L) 0.363
  ≥ 40 35 (28.2) 22 (31.0) 16 (21.1)  
  <  40 89 (71.8) 49 (69.0) 60 (78.9)  
AST (U/L) 0.633
  ≥ 40 41 (33.1) 19 (26.8) 25 (32.9)  
  <  40 83 (66.9) 52 (73.2) 51 (67.1)  
LDH (U/L) 0.341
  ≥ 245 36 (29.0) 26 (36.6) 29 (38.2)  
  <  245 88 (71.0) 45 (63.4) 47 (61.8)  
γ-GT (U/L) 0.262
  ≥ 50 64 (51.6) 28 (39.4) 36 (47.4)  
  <  50 60 (48.4) 43 (60.6) 40 (52.6)  
Cr (μmol/L) 0.303
  > 80 41 (33.1) 29 (40.9) 21 (27.6)  
  ≤ 80 83 (66.9) 42 (59.1) 55 (72.4)  
Outcomes 0.070
 Dead 22 (17.7) 22 (31.0) 14 (18.4)  
 Alive 102 (82.3) 49 (69.0) 62 (81.6)  
  1. WBC White blood cell, PLT Platelet, CRP C-reactive protein, PCT Procalcitonin, IL-6 Interleukin-6, SaO2 Oxygen saturation, TBIL Total bilirubin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, LDH Lactate dehydrogenase, γ-GT γ-glutamyl transpeptadase, Cr Creatinine