Fig. 1
From: Toll-like receptor 5-mediated signaling enhances liver regeneration in mice
TLR5 is up-regulated in the liver after PHx. a Flagellin concentrations in the serum and liver in WT mice 6 h after sham surgery or PHx. b TLR expression levels in regenerating WT mouse liver after PHx from a published transcriptome dataset (GSE95135). c Relative mRNA levels of hepatic TLR5 at the indicated times after PHx. Flow cytometry gating strategy (d) and TLR5 expression levels (e) of liver neutrophils, KCs, and recruited macrophages in WT mice. f Cell counts and mean fluorescence intensity of TLR5 on liver neutrophils, KCs, and recruited macrophages at the indicated times after PHx. Panel a shows means ± SD. Data are representative of three independent experiments. Panels c and f show means ± SEM. Data are derived from two or three independent experiments with similar results. n = 3–6. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001