EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

Table 6 Associations analyses between SNPs and AMS-related symptoms

SNP ID	Gene	Genotype	HD			DL			GI			FA
SNP ID	Gene	Genotype	OR (95% CI) OR (95% CI)^a	P-value P-value^a	Q-value	OR (95% CI) OR (95% CI)^a	P-value P-value^a	Q-value	OR (95% CI) OR (95% CI)^a	P-valueP-value^a	Q-value	OR (95% CI) OR (95% CI)^a	P-valueP-value^a	Q-value
rs2153364	EGLN1	AA	1.26 (0.84–1.90)	0.270	0.250	1.39 (0.93–2.08)	0.110	0.098	1.29 (0.81–2.06)	0.270	0.540	1.26 (0.85–1.87)	0.250	0.220
rs2153364	EGLN1	AG/GG	1.28 (0.84–1.93)	0.250	0.250	1.41 (0.94–2.11)	0.098	0.098	1.29 (0.81–2.07)	0.270	0.540	1.28 (0.86–1.91)	0.220	0.220
rs6756667	EPAS1	GG	0.70 (0.46–1.05)	0.091	0.117	0.68 (0.45–1.03)	0.070	0.154	0.54 (0.32–0.90)	0.014*	0.052	0.69 (0.46–1.03)	0.070	0.264
rs6756667	EPAS1	GA/AA	0.69 (0.46–1.05)	0.088	0.117	0.69 (0.46–1.04)	0.077	0.154	0.53 (0.32–0.89)	0.013*	0.052	0.68 (0.46–1.02)	0.066	0.264
rs3025039	VEGFA	CC	2.08 (1.34–3.23)	< 0.001*	0.028*	1.40 (0.93–2.10)	0.100	0.107	0.99 (0.65–1.52)	0.960	0.950	1.42 (0.96–2.11)	0.073	0.178
rs3025039	VEGFA	CT/TT	2.08 (1.34–3.23)	0.0007*	0.028*	1.43 (0.95–2.16)	0.080	0.107	0.99 (0.64–1.51)	0.950	0.950	1.40 (0.95–2.08)	0.089	0.178
rs7292407	PPARA	CC	0.68 (0.45–1.01)	0.058	0.160	0.71 (0.48–1.05)	0.091	0.264	0.80 (0.50–1.26)	0.330	0.493	0.72 (0.49–1.06)	0.094	0.160
rs7292407	PPARA	AC/AA	0.70 (0.46–1.04)	0.080	0.160	0.68 (0.46–1.02)	0.066	0.264	0.81 (0.51–1.29)	0.370	0.493	0.73 (0.49–1.08)	0.120	0.160

^a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including above 4 SNPs. AMS Acute mountain sickness; HD Headache; DL Dizziness and light-headedness; GI Gastrointestinal symptoms; FA Fatigue and/or weakness; OR Odds ratio; CI Confidence interval

ISSN: 2054-9369