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Table 6 Associations analyses between SNPs and AMS-related symptoms

From: EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

SNP ID Gene Genotype HD DL GI FA
OR (95% CI)
OR (95% CI)a
P-value
P-valuea
Q-value OR (95% CI)
OR (95% CI)a
P-value
P-valuea
Q-value OR (95% CI)
OR (95% CI)a
P-valueP-valuea Q-value OR (95% CI)
OR (95% CI)a
P-valueP-valuea Q-value
rs2153364 EGLN1 AA 1.26 (0.84–1.90) 0.270 0.250 1.39 (0.93–2.08) 0.110 0.098 1.29 (0.81–2.06) 0.270 0.540 1.26 (0.85–1.87) 0.250 0.220
AG/GG 1.28 (0.84–1.93) 0.250 1.41 (0.94–2.11) 0.098 1.29 (0.81–2.07) 0.270 1.28 (0.86–1.91) 0.220
rs6756667 EPAS1 GG 0.70 (0.46–1.05) 0.091 0.117 0.68 (0.45–1.03) 0.070 0.154 0.54 (0.32–0.90) 0.014* 0.052 0.69 (0.46–1.03) 0.070 0.264
GA/AA 0.69 (0.46–1.05) 0.088 0.69 (0.46–1.04) 0.077 0.53 (0.32–0.89) 0.013* 0.68 (0.46–1.02) 0.066
rs3025039 VEGFA CC 2.08 (1.34–3.23) < 0.001* 0.028* 1.40 (0.93–2.10) 0.100 0.107 0.99 (0.65–1.52) 0.960 0.950 1.42 (0.96–2.11) 0.073 0.178
CT/TT 2.08 (1.34–3.23) 0.0007* 1.43 (0.95–2.16) 0.080 0.99 (0.64–1.51) 0.950 1.40 (0.95–2.08) 0.089
rs7292407 PPARA CC 0.68 (0.45–1.01) 0.058 0.160 0.71 (0.48–1.05) 0.091 0.264 0.80 (0.50–1.26) 0.330 0.493 0.72 (0.49–1.06) 0.094 0.160
AC/AA 0.70 (0.46–1.04) 0.080 0.68 (0.46–1.02) 0.066 0.81 (0.51–1.29) 0.370 0.73 (0.49–1.08) 0.120
  1. a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including above 4 SNPs. AMS Acute mountain sickness; HD Headache; DL Dizziness and light-headedness; GI Gastrointestinal symptoms; FA Fatigue and/or weakness; OR Odds ratio; CI Confidence interval