Table 2 Top 20 DE genes between control and M. vaccae groups

Retnlg

5.2646E-11

3.00721E-07

6.762246

Up

NM_181596

Unknown

Tiprl

6.7691E-11

3.00721E-07

2.3434467

Up

NM_145513

Unknown

Gyg

1.0686E-10

3.00721E-07

2.590874

Up

NM_013755

Unknown

Ptgs2

1.1782E-10

3.00721E-07

33.16254

Up

NM_011198

Decreased transcription of PTGS2 was beneficial to the survival of M. tuberculosis

Zfp281

1.9767E-10

3.00721E-07

3.3773346

Up

NM_177643

Unknown

Gbp2

2.162E-10

3.00721E-07

8.493201

Up

NM_010260

One of prominent hubs in a highly active common core in TB

Cxcl2

2.2714E-10

3.00721E-07

176.0849

Up

NM_009140

Blocking of CXCL2 can significantly reduce the M. tuberculosis-induced IL-1β production

Ear6

2.4307E-10

3.00721E-07

30.299973

Up

NM_053111

Unknown

Ighv1–77

4.1282E-10

4.21673E-07

4.998427

Up

AF045501

Unknown

Slpi

5.6974E-10

4.97498E-07

3.1604574

Up

NM_011414

Exposure of murine peritoneal macrophages to M. tuberculosis led to an increase in SLPI secretion accelerating both the phagocytosis and killing of the pathogen

Azin1

5.9447E-10

4.97498E-07

2.5270393

Up

NM_018745

Unknown

S100a8

7.0447E-10

4.97498E-07

9.958652

Up

NM_013650

A major pathologic role for S100A8/A9 proteins in decreasing lung tissue damage without impacting protective immunity against TB

Ccrl2

7.0963E-10

4.97498E-07

10.672567

Up

NM_017466

Unknown

Igj

8.5416E-10

5.25022E-07

4.127778

Up

NM_152839

Unknown

Tnf

9.694E-10

5.66345E-07

156.13841

Up

NM_013693

TNF-α has a prominent role in defense and pathological responses to TB and its production in TB patients was higher than that in the control group

Prkcd

1.1807E-09

6.28255E-07

2.054293

Up

NM_011103

Unknown

Marcksl1

1.2759E-09

6.28255E-07

11.7962

Up

NM_010807

Unknown

Prss34

1.3143E-09

6.28255E-07

11.188594

Up

NM_178372

Unknown

Cct6a

1.4218E-09

6.40172E-07

2.9756305

Up

NM_009838

Unknown

Il1a

1.5183E-09

6.40172E-07

48.50243

Up

NM_010554

The expression of the IL1A gene was increased in both the TB-infected and the healthy cattle to M. bovis stimulation

Afp

2.4759E-11

3.00721E-07

5.7038527

Down

NM_007423

Only a few literatures reported that AFP was normal in TB patients, but increased significantly in TB patients with hepatocellular carcinoma

Pcdhga9

8.4144E-11

3.00721E-07

2.3555577

Down

NM_033592

Unknown

Cdc42ep5

1.2007E-10

3.00721E-07

3.3431478

Down

NM_021454

Unknown

Hrsp12

1.5283E-10

3.00721E-07

2.9907024

Down

NM_008287

Unknown

Rnasek

1.5763E-10

3.00721E-07

2.0300574

Down

NM_173742

Unknown

Nprl3

1.6254E-10

3.00721E-07

2.5463195

Down

NM_001284359

Unknown

4932443I19Rik

1.9509E-10

3.00721E-07

6.6056542

Down

NM_001101519

Unknown

Ly6g6c

2.3228E-10

3.00721E-07

3.6154532

Down

NM_023463

Unknown

Kdr

2.6218E-10

3.06341E-07

4.521906

Down

NM_010612

Unknown

2810416G20Rik

3.0664E-10

3.39439E-07

4.7047515

Down

XM_003945668

Unknown

Tubb2a

4.3967E-10

4.21673E-07

3.6115813

Down

NM_009450

Unknown

Triqk

4.4108E-10

4.21673E-07

4.918867

Down

NM_173746

Unknown

Slc6a16

6.2508E-10

4.97498E-07

4.1382565

Down

XM_355900

Unknown

Cxx1c

8.1855E-10

5.25022E-07

3.0826645

Down

NM_028375

Unknown

Fez2

8.6019E-10

5.25022E-07

2.6090815

Down

NM_001285940

Unknown

1810058I24Rik

8.7371E-10

5.25022E-07

4.307958

Down

NR_027875

Unknown

Egfbp2

1.0983E-09

6.07878E-07

4.641702

Down

NM_010115

Unknown

Efna5

1.2336E-09

6.28255E-07

2.744601

Down

NM_207654

Unknown

Cd151

1.2898E-09

6.28255E-07

3.2171504

Down

NM_009842

CD9^High classical monocytes expressed higher levels of tetraspanin CD151 compared to CD9^Low classical monocytes

2210013O21Rik

1.4572E-09

6.40172E-07

3.4838674

Down

NM_027327

Unknown