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Table 2 Routine screening for thrombocytopenia

From: Expert consensus on the diagnosis and treatment of thrombocytopenia in adult critical care patients in China

ItemDiagnosis
Blood test; C-reactive protein (CRP); procalcitonin (PCT)Severe infection; hematological disease
Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib), D-dimer (DD), fibrindegradation products (FDP)DIC; the cause should be determined
Alanine aminotransferase (ALT), aspartate aminotransferase(AST), creatinine (Cr), total bilirubin (TBil)Thrombocytopenia due to liver and renal impairment
Lactic acid dehydrogenase (LDH)Hemolytic anemia; paroxysmal nocturnal hemoglobinuria
Vitamin B12, folic acidMalnutrition-associated thrombocytopenia
EBvirus, cytomegalovirus (CMV), hepatitis B virus (HBV), hepatitis C virus (HCV), HIVViral infection
Antinuclear antibodies (ANA), rheumatoid factor (RF)Autoimmune diseases such as SLE, Sjogren’s syndrome, and RA