Table 2 Routine screening for thrombocytopenia

Blood test; C-reactive protein (CRP); procalcitonin (PCT)

Severe infection; hematological disease

Prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib), D-dimer (DD), fibrindegradation products (FDP)

DIC; the cause should be determined

Alanine aminotransferase (ALT), aspartate aminotransferase(AST), creatinine (Cr), total bilirubin (TBil)

Thrombocytopenia due to liver and renal impairment

Lactic acid dehydrogenase (LDH)

Hemolytic anemia; paroxysmal nocturnal hemoglobinuria

Vitamin B12, folic acid

Malnutrition-associated thrombocytopenia

EBvirus, cytomegalovirus (CMV), hepatitis B virus (HBV), hepatitis C virus (HCV), HIV

Viral infection

Antinuclear antibodies (ANA), rheumatoid factor (RF)

Autoimmune diseases such as SLE, Sjogren’s syndrome, and RA