Does the preoperative platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio predict morbidity after gastrectomy for gastric cancer?

İbrahim Mungan; Çilem Bayındır Dicle; Şerife Bektaş; Sema Sarı; Serdar Yamanyar; Mine Çavuş; Sema Turan; Erdal Birol Bostancı

doi:10.1186/s40779-020-00234-y

Military Medical Research

Table 3 Demographic and clinicopathological variables compared according to the PLR and NLR values

From: Does the preoperative platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio predict morbidity after gastrectomy for gastric cancer?

Item	All (N = 292)	PLR ≤ 0.55 (n = 89)	PLR > 0.55 (n = 203)	P value⁺	NLR ≤ 3.92 (n = 226)	NLR > 3.92 (n = 66)	P value⁺
Age (years, mean ± SD)	61.1 ± 11.3	64.6 ± 11.0	59.6 ± 11.1	< 0.001^*	60.3 ± 11.2	64 ± 11.2	0.033^*
Sex (Male) [n(%)]	196 (67.1)	65 (73.0)	131 (64.5)	0.156	147 (65.0)	49 (74.2)	0.163
AJCC stage				0.01^3*			0.004^*
Stage 1[n(%)]	70 (24.0)	15 (16.9)	55 (27.1)		62 (27.4)	8 (12.1)
Stage 2[n(%)]	82 (28.1)	25 (28.1)	57 (28.1)		64 (28.3)	18 (27.3)
Stage 3[n(%)]	107 (36.6)	32 (36.0)	75 (36.9)		78 (34.5)	29 (43.9)
Stage 4[n(%)]	33 (11.3)	17 (19.1)	16 (7.9)		22 (9.7)	11 (16.7)
Tumor extent (size)				0.002^*			0.001^*
1[n(%)]	62 (21.2)	11 (12.4)	51 (25.1)		57 (25.2)	5 (7.6)
2[n(%)]	40 (13.7)	12 (13.5)	28 (13.8)		32 (14.2)	8 (12.1)
3[n(%)]	164 (56.2)	52 (58.4)	112 (55.2)		120 (53.1)	44 (66.7)
4[n(%)]	26 (8.9)	14 (15.7)	12 (5.9)		17 (7.5)	9 (13.6)
Lymph node count				0.794			0.240
0[n(%)]	83 (28.4)	24 (27.0)	59 (29.1)		68 (30.1)	15 (22.7)
1[n(%)]	60 (20.5)	18 (20.2)	42 (20.7)		48 (21.2)	12 (18.2)
2[n(%)]	50 (17.1)	17 (19.1)	33 (16.3)		35 (15.5)	15 (22.7)
3[n(%)]	99 (33.9)	30 (33.7)	69 (34.0)		75 (33.2)	24 (36.4)
Distant metastases [n(%)]	33 (11.3)	17 (19.1)	16 (7.9)	0.005^*	22(9.7)	11 (16.7)	0.118
Location of the tumor				0.259			0.840
Cardia/ fundus [n(%)]	54 (18.5)	24 (27.0)	30 (14.8)		39 (17.3)	15 (22.7)
Body [n(%)]	194 (66.4)	49 (55.1)	145 (71.4)		155 (68.6)	39 (59.1)
Antrum/ pylorus [n(%)]	44 (15.1)	16 (18.0)	28 (13.8)		32 (14.2)	12 (18.2)
Total gastrectomy [n(%)]	152 (52.1)	53(59.6)	99 (48.8)	0.090	116 (51.3)	36 (54.5)	0.647
Size of the tumor> 3 cm [n(%)]	221 (75.7)	71 (79.8)	150 (73.9)	0.282	166 (73.5)	55 (83.3)	0.100
Histological grade				0.542			0.852
Well differentiated [n(%)]	71 (24.3)	20 (22.5)	51 (25.1)		55 (24.3)	16 (24.2)
Moderately differentiated [n(%)]	103 (35.3)	36 (40.4)	67 (33.0)		81 (35.8)	22 (33.3)
Poorly differentiated [n(%)]	77 (26.4)	25 (28.1)	52 (25.6)		58 (25.7)	19 (28.8)
Signet ring [n(%)]	41 (14.0)	8 (9.0)	33 (16.3)		32 (14.2)	9 (13.6)
Lymphatic invasion [n(%)]	211 (72.3)	66 (74.2)	145 (71.4)	0.633	155 (68.6)	56 (84.8)	0.009^*
Perineural invasion [n(%)]	161 (55.1)	50 (56.2)	111 (54.7)	0.737	118 (52.2)	43 (65.2)	0.047^*
Vascular invasion [n(%)]	170 (58.2)	54 (60.7)	116 (57.1)	0.575	126 (55.8)	44 (66.7)	0.115

P value⁺ were calculated for the comparison of groups based on the NLR and PLR values by statistical analysis; +Determined by the Mann-Whitney U test or Spearman’s rho test; *. P value < 0.05; AJCC American Joint Committee on Cancer, PLR platelet-to-lymphocyte ratio, NLR neutrophil-to-lymphocyte ratio

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