Table 1 Main target genes of the differentially expressed miRNAs in the 12-h group compared with 2-h group
Change in miRNA expression | Name of miRNA | Predicted target genes |
|---|---|---|
Upregulated | miR-18a | Neural precursor cell expressed; developmentally regulated protein 9; glycine receptor |
miR-203 | 4/all family, member 4; elongation factor RNA polymerase II, 2 | |
miR-146a | Zinc finger protein 826; tumor necrosis factor receptor-associated factor 6 (TRAF6) | |
miR-149 | AP2-associated protein kinase 1; PH domain and leucine-rich repeat protein phosphatase | |
miR-23b | Zinc finger protein 138; fucosyltransferase (alpha-fucosyltransferase (1,3) 9 | |
miR-let-7f | High mobility group AT-hook 2; chromosome 14 open reading frame 28 | |
miR-let-7b | High mobility group AT-hook 2; chromosome 14 open reading frame 28 | |
miR-132 | Transmembrane protein 106B; zinc finger protein 516 | |
miR-128a | Inflammatory pathways | |
miR-372 | Involved in DNA damage response | |
Downregulated | miR-let-7a | angiogenesis in rheumatoid arthritis via HIF-1α activation |
miR-214 | NMDA receptor-regulated 2; κ-opioid receptor | |
miR-199a-3p | Cadherin EGF LAG seven pass G-Type receptor 2; SH3 domain-containing GRB2-like endophilin B1 |