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Table 3 Responses of the yields of secondary metabolites to simulated microgravity and spaceflight

From: Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism

Strain Antibiotics Response Equipment
Streptomyces clavuligerus ATCC 27064 [77] β-lactam antibiotic cephalosporin Inhibited High-aspect rotating vessels (HARV)
Streptomyces hygroscopicus ATCC 29253 [76] Rapamycin Inhibited Rotating-wall bioreactor (RWB)
Streptomyces ansochromogenus 7100 [100] Nikkomycin X, Z Increased Unmanned satellite
Streptomyces avermitilis PE1 [57] Avermectin Increased Diamagnetic levitation
Streptomyces plicatus WC56452 [27] Actinomycin D Increased US Space Shuttle mission STS-80
Streptomyces plicatus WC56452 [5] Actinomycin D Increased and then decreased International space station (ISS)
Escherichia coli ZK650 [65] Microcin B17 Inhibited High-aspect rotating vessels (HARV)
Bacillus brevis Nagano [94] Gramicidin S Unaffected High-aspect rotating vessels (HARV)
Humicola fuscoatra WC5157 [23] Monorden Increased US Space Shuttle mission STS-77
Microcystis aeruginosa PCC7806 [101] Microcystin Increased Rotary cell culture system (RCCS)
Cupriavidus metallidurans LMG 1195 [21] Poly-β-hydroxybutyrate (PHB) Increased and then decreased Rotating wall vessel (RWV)
Streptomyces coelicolor A3(2) [95] Undecylprodigiosin (RED) Increased slightly 2D-clinostat (SM-1)
Streptomyces coelicolor A3(2) [95] Actinorhodin (ACT) Inhibited 2D-clinostat (SM-1), Shenzhou-8 Space mission