Table 1 Diagnostic criteria for sepsis reproduced from the Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society (SCCM/ESICM/ACCP/ATS/SIS) International Sepsis Definitions Conference in 2001
From: Current knowledge and future directions of TLR and NOD signaling in sepsis
Infection (1) : Documented or suspected and some of the following (2) | |
|---|---|
General parameters | Fever (core temperature >38.3°C) |
Hypothermia (core temperature <36°C) | |
Heart rate >90 beats per minute or >2 SD above the normal value for age | |
Tachypnoea >30 breaths per minute | |
Altered mental state | |
Significant oedema or positive fluid balance (>20 ml/kg over 24 hrs) | |
Hyperglycaemia (plasma glucose >110 mg/dL or 7.7 mmol/L in the absence of diabetes | |
Inflammatory parameters | Leukocytosis (white blood cell count >12,000/μL) |
Leukopaenia (white blood cell count <4,000/μL) | |
Normal white blood cell count with >10% immature forms | |
Plasma C reactive protein >2 SD above the normal value | |
Plasma procalcitonin >2 SD above the normal value | |
Haemodynamic parameters | Arterial hypotension(2) (systolic blood pressure <90 mmHg, mean arterial pressure <70 mmHg or a systolic blood pressure decrease >40 mmHg in adults or <2 SD below the normal value for age) |
Mixed venous oxygen saturation >70%(2) | |
Cardiac index >3.5 L/min/m2(3,4) | |
Organ dysfunction parameters | Arterial hypoxaemia (PaO2/FiO2 <300) |
Acute oliguria (urine output <0.5 ml/kg/hr or 45 mmol/L for at least 2 hrs) | |
Creatinine increase ≥0.5 mg/dL | |
Coagulation abnormalities (international normalised ratio >1.5 or activated partial thromboplastin time >60 seconds) | |
Ileus (absent bowel sounds) | |
Thrombocytopenia (platelet count <100,000/μL) | |
Hyperbilirubinaemia (plasma total bilirubin >4 mg/dL or 70 mmol/L) | |
Tissue perfusion parameters | Hyperlactatemia (>3 mmol/L) |
Decreased capillary refill or mottling | |