Articles
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Citation: Military Medical Research 2022 9:67
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Data analysis guidelines for single-cell RNA-seq in biomedical studies and clinical applications
The application of single-cell RNA sequencing (scRNA-seq) in biomedical research has advanced our understanding of the pathogenesis of disease and provided valuable insights into new diagnostic and therapeutic...
Citation: Military Medical Research 2022 9:68 -
Enzymatic debridement shall not modify the global strategy for mass burn events
Citation: Military Medical Research 2022 9:66 -
The role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types, whose activity and interplay must be precisely mediated for effective healing post-injury. ...
Citation: Military Medical Research 2022 9:65 -
Surveillance of arthropod-borne viruses in Benin, West Africa 2020–2021: detection of dengue virus 3 in Aedes aegypti (Diptera: Culicidae)
Citation: Military Medical Research 2022 9:64 -
Introduction of monkeypox virus in Benin, 2022
Citation: Military Medical Research 2022 9:63 -
Alterations in the human oral microbiome in cholangiocarcinoma
Citation: Military Medical Research 2022 9:62 -
Extracellular vesicles in the pathogenesis and treatment of acute lung injury
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening lung diseases associated with acute and severe inflammation. Both have high mortality rates, and despite decad...
Citation: Military Medical Research 2022 9:61 -
Preemptive targeted muscle reinnervation: the single incision approach should be avoided in trans-tibial traumatic amputation
Citation: Military Medical Research 2022 9:60 -
Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial
Although clozapine is an effective option for treatment-resistant schizophrenia (TRS), there are still 1/3 to 1/2 of TRS patients who do not respond to clozapine. The main purpose of this randomized, double-bl...
Citation: Military Medical Research 2022 9:59 -
Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias
Abnormal myocardial Nav1.5 expression and function cause lethal ventricular arrhythmias during myocardial ischemia–reperfusion (I/R). Protein inhibitor of activated STAT Y (PIASy)-mediated caveolin-3 (Cav-3) SUMO...
Citation: Military Medical Research 2022 9:58 -
Personalized pancreatic cancer therapy: from the perspective of mRNA vaccine
Pancreatic cancer is characterized by inter-tumoral and intra-tumoral heterogeneity, especially in genetic alteration and microenvironment. Conventional therapeutic strategies for pancreatic cancer usually suf...
Citation: Military Medical Research 2022 9:53 -
Comparison of emergency surgical cricothyroidotomy and percutaneous cricothyroidotomy by experienced airway providers in an obese, in vivo porcine hemorrhage airway model
Emergency front-of-neck airway (eFONA) is a life-saving procedure in “cannot intubate, cannot oxygenate” (CICO). The fastest and most reliable method of eFONA has not been determined. We compared two of the mo...
Citation: Military Medical Research 2022 9:57 -
Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options
Sepsis is a common complication of combat injuries and trauma, and is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection. It is also one of the significant caus...
Citation: Military Medical Research 2022 9:56 -
Monkeypox outbreak in the age of COVID-19: a new global health emergency
Citation: Military Medical Research 2022 9:55 -
Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability
Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal sq...
Citation: Military Medical Research 2022 9:54 -
Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy
The advent of single-cell RNA sequencing (scRNA-seq) has provided insight into the tumour immune microenvironment (TIME). This review focuses on the application of scRNA-seq in investigation of the TIME. Over ...
Citation: Military Medical Research 2022 9:52 -
An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening
Tumor cell heterogeneity mediated drug resistance has been recognized as the stumbling block of cancer treatment. Elucidating the cytotoxicity of anticancer drugs at single-cell level in a high-throughput way ...
Citation: Military Medical Research 2022 9:51 -
The relationship between chronic PTSD, cortical volumetry and white matter microstructure among Australian combat veterans
Posttraumatic stress disorder (PTSD) has been associated with volumetric and white matter microstructural changes among general and veteran populations. However, regions implicated have greatly varied and ofte...
Citation: Military Medical Research 2022 9:50 -
Gastrointestinal dysfunction is associated with mortality in severe burn patients: a 10-year retrospective observational study from South China
Data on severe and extensive burns in China are limited, as is data on the prevalence of a range of related gastrointestinal (GI) disorders [such as stress ulcers, delayed defecation, opioid-related bowel immo...
Citation: Military Medical Research 2022 9:49 -
Masquelet technique in military practice: specificities and future directions for combat-related bone defect reconstruction
Because of its simplicity, reliability, and replicability, the Masquelet induced membrane technique (IMT) has become one of the preferred methods for critical bone defect reconstruction in extremities. Althoug...
Citation: Military Medical Research 2022 9:48 -
Correction: Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Citation: Military Medical Research 2022 9:47 -
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles
Wear particles-induced osteolysis is a major long-term complication after total joint arthroplasty. Up to now, there is no effective treatment for wear particles-induced osteolysis except for the revision surg...
Citation: Military Medical Research 2022 9:46 -
DPP-4 inhibitors and GLP-1RAs: cardiovascular safety and benefits
Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used treatments for patients with type 2 diabetes mellitus (T2DM). Both anti-diabetic treatments function by playing...
Citation: Military Medical Research 2022 9:45 -
Treatment and surveillance for non-muscle-invasive bladder cancer: a clinical practice guideline (2021 edition)
Non-muscle invasive bladder cancer (NMIBC) is a major type of bladder cancer with a high incidence worldwide, resulting in a great disease burden. Treatment and surveillance are the most important part of NIMB...
Citation: Military Medical Research 2022 9:44 -
Multifaceted roles of extracellular RNAs in different diseases
Extracellular RNAs (exRNAs) are novel circulating factors that can be used as biomarkers in various diseases. Their unique and diverse kinds, as well as their role as biomarkers, make them significant biomarke...
Citation: Military Medical Research 2022 9:43 -
Early burn wound excision in mass casualty events
Citation: Military Medical Research 2022 9:42 -
The minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing
Citation: Military Medical Research 2022 9:41 -
The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer
Overexpression of human epidermal growth factor receptor 2 (HER2) occurs in approximately 15–20% of breast cancer cases. HER2 is a member of the epidermal growth factor receptor (EGFR) family with tyrosinase k...
Citation: Military Medical Research 2022 9:39 -
mRNA vaccine development for cholangiocarcinoma: a precise pipeline
Cholangiocarcinoma (CHOL) is one of the most aggressive tumors worldwide and cannot be effectively treated by conventional and novel treatments, including immune checkpoint blockade therapy. The mRNA vaccine-b...
Citation: Military Medical Research 2022 9:40 -
Intracellular accumulation of tau inhibits autophagosome formation by activating TIA1-amino acid-mTORC1 signaling
Autophagy dysfunction plays a crucial role in tau accumulation and neurodegeneration in Alzheimer’s disease (AD). This study aimed to investigate whether and how the accumulating tau may in turn affect autophagy.
Citation: Military Medical Research 2022 9:38 -
Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury
Traumatic colon injury (TCI) is a common disease during wartime. Prolongation of posttraumatic survival time is an effective approach to patient outcome improvement. However, there is a lack of basic research ...
Citation: Military Medical Research 2022 9:37 -
Lethal means and suicide prevention among military veterans
Citation: Military Medical Research 2022 9:36 -
Caloric restriction-mimetics for the reduction of heart failure risk in aging heart: with consideration of gender-related differences
The literature is full of claims regarding the consumption of polyphenol or polyamine-rich foods that offer some protection from developing cardiovascular disease (CVD). This is achieved by preventing cardiac ...
Citation: Military Medical Research 2022 9:33 -
TRIM72-mediated degradation of the short form of p62/SQSTM1 rheostatically controls selective autophagy in human cells
Citation: Military Medical Research 2022 9:35 -
Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
Citation: Military Medical Research 2022 9:34 -
Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up
Due to the outbreak and rapid spread of coronavirus disease 2019 (COVID-19), more than 160 million patients have become convalescents worldwide to date. Significant alterations have occurred in the gut and ora...
Citation: Military Medical Research 2022 9:32 -
An unfolding monkeypox outbreak in Europe and beyond
Citation: Military Medical Research 2022 9:31 -
Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA
Malaria is a devastating infectious disease that disproportionally threatens hundreds of millions of people in developing countries. In the history of anti-malaria campaign, chloroquine (CQ) has played an indi...
Citation: Military Medical Research 2022 9:30 -
Monkeypox outbreak: A novel threat after COVID-19?
Citation: Military Medical Research 2022 9:29 -
Pushing the frontiers of military medical excellence: updates, progress and future needs
Since its establishment in 2014, Military Medical Research has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with mili...
Citation: Military Medical Research 2022 9:27 -
Molecular diagnostic approaches for enteric parasites: an issue of relevance for deployed soldiers?
Citation: Military Medical Research 2022 9:28 -
Nanosensitizers for sonodynamic therapy for glioblastoma multiforme: current progress and future perspectives
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is associated with poor prognosis. Its characteristics of being highly invasive and undergoing heterogeneous genetic mutat...
Citation: Military Medical Research 2022 9:26 -
Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1/RIP3-exosome axis
Cerebral ischemia-reperfusion injury (CIRI) refers to a secondary brain injury that can occur when the blood supply to the ischemic brain tissue is restored. However, the mechanism underlying such injury remai...
Citation: Military Medical Research 2022 9:25 -
Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients
Mucosal-associated invariant T (MAIT) cells are systemically depleted in human immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after successful combined antiretroviral ther...
Citation: Military Medical Research 2022 9:24 -
Down-regulation of Risa improves podocyte injury by enhancing autophagy in diabetic nephropathy
LncRNA AK044604 (regulator of insulin sensitivity and autophagy, Risa) and autophagy-related factors Sirt1 and GSK3β play important roles in diabetic nephropathy (DN). In this study, we sought to explore the effe...
Citation: Military Medical Research 2022 9:23 -
Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
Sepsis involves life-threatening organ dysfunction and is caused by a dysregulated host response to infection. No specific therapies against sepsis have been reported. Celastrol (Cel) is a natural anti-inflamm...
Citation: Military Medical Research 2022 9:22 -
Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no established treatment and is characterized by progressive scarring of the lung tissue and an irreversible decline in lun...
Citation: Military Medical Research 2022 9:21 -
Management of granulomatous lobular mastitis: an international multidisciplinary consensus (2021 edition)
Granulomatous lobular mastitis (GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care f...
Citation: Military Medical Research 2022 9:20 -
N6-methyladenosine modification of CENPK mRNA by ZC3H13 promotes cervical cancer stemness and chemoresistance
Stemness and chemoresistance contribute to cervical cancer recurrence and metastasis. In the current study, we determined the relevant players and role of N6-methyladenine (m6A) RNA methylation in cervical cancer...
Citation: Military Medical Research 2022 9:19
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- ISSN: 2054-9369 (electronic)