Fig. 3
From: Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Current approaches for heart regeneration. Current attempts at heart regenerative therapies include cell based and non-cell based approaches. Each of these approaches has its own advantages and faces different challenges. iPSC induced pluripotent stem cell, BMC bone marrow cell, MSC mesenchymal stem cell, Cdk1 cyclin-dependent kinase 1, Ccnb cyclin B, SOX2 SRY-box transcription factor 2, OCT4 POU domain, class 5, transcription factor 1, KLF4 KLF transcription factor 4, YAP Yes-associated protein, Nrg neuregulin, FGF fibroblast growth factor, VEGF vascular endothelial growth factor, GATA4 GATA binding protein 4, HAND2 heart and neural crest derivatives expressed transcript 2, MEF2C Myocyte enhancer factor 2C, TBX5 T-box transcription factor 5