Fig. 2
From: Regeneration of the heart: from molecular mechanisms to clinical therapeutics
Signaling pathways in heart repair and regeneration. Hippo-YAP, Notch and Nrg-ErbB signaling pathways are the major players in regulating heart repair and regeneration after injuries. Hippo-Yap regulates cardiomyocyte proliferation, migration, and apoptosis, thus affecting scar formation after injury. Notch signaling controls cardiomyocyte proliferation, as well as immune cell infiltration and endocardial cell maturation. Nrg-ErbB signaling affects cardiomyocyte dedifferentiation, division, and survival. FAT4 FAT atypical cadherin 4, MST macrophage stimulating, SAV1 salvador family domain-containing protein 1, LATS large tumor suppressor kinase, MOB1 MOB kinase activator 1, YAP Yes-associated protein, TAZ tafazzin, phospholipid-lysophospholipid transacylase, TEAD TEA domain family, ADAM ADAM metallopeptidase domain, NICD Notch intracellular domain, MAM mastermind, CSL citrate synthase like, ErbB2 Erb-B2 receptor tyrosine kinase, RAF v-raf-leukemia viral oncogene, PI3K phosphatidylinositol 3-kinase, MEK1 mitogen-activated protein kinase kinase 1, ERK extracellular signal-regulated kinase, Akt protein kinase B, mTOR mechanistic target of rapamycin kinase, JUN Jun proto-oncogene, ETS ETS transcription factor family, FOS FBJ osteosarcoma oncogene, LRP LDL receptor related protein, GSK-3β glycogen synthase kinase-3 beta, TCF T-cell factor, LEF lymphoid enhancer factor