Fig. 6
From: Applications and prospects of cryo-EM in drug discovery
Application of cryo-EM in drug repurposing and drug failure. a, b Structures of γ-secretase bound to its substrates (PDB: 6IYC, 6IDF. EMDB: EMD-9751, EMD-9648). c Modulators and inhibitors of γ-secretase bound to allosteric and active sites (PDB: 6LR4, 6LQG, 7C9I, 7D8X. EMDB: EMD-0957, EMD-0944, EMD-30312, EMD-30614). d Molecular glues mediate the interaction of PDE3A and SLFN12 (PDB: 7EG0, 7EG1, 7EG4. EMDB: EMD-31103, EMD-31104, EMD-31105). APP amyloid precursor protein, NCT nicastrin, PEN2 presenilin enhancer 2, PS1 presenilin 1, APH-1 anterior pharynx-defective 1, PDE3A phosphodiesterase 3A, SLFN12 schlafen protein family 12, DNMDP 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydropyridazin-3(2H)-one