Fig. 5
From: Applications and prospects of cryo-EM in drug discovery
Application of cryo-EM in antibody drug development. a Replication cycle of SARS-CoV-2. b Structure of S-ACE2 complex associates with the designation of ambavirumab and romisevirumab (EMDB: EMD-25760). c Schematic diagram of cryo-EM and sequencing based antibody discovery. SARS-CoV2 severe acute respiratory syndrome coronavirus 2, ACE2 angiotensin-converting enzyme 2, TMPRESS2 Transmembrane serine protease 2, IFN type I interferon, RBD receptor-binding domain, RNA ribonucleic acid