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Fig. 4 | Military Medical Research

Fig. 4

From: Applications and prospects of cryo-EM in drug discovery

Fig. 4

Application of cryo-EM in proteolysis targeting chimera (PROTAC). a Schematic diagram of PROTAC technology. b Cartoon display of the MZ1 mediated BRD4-VHL complex and the design of the MZ1 (PDB: 5T35). c Structure of the trivalent PROTAC. d Cartoon display of the human DCAF15-DDB1-DDA1-RBM39 complex with indisulam (PDB: 6SJ7. EMDB: EMD-10213). e BacPROTAC mediated ClpC activation for target protein degradation (EMDB: EMD-11707, EMD-11708). PROTAC proteolysis targeting chimera, BRD4 bromodomain-containing protein 4, VHL Von Hippel-Lindau, Ub ubiquitin, E2/3 ubiquitin protein ligases 2/3, BET bromodomain and extra-terminal domain, DCAF15 DDB1 and CUL4 associated factor 15, DDB1 DNA damage-binding protein 1, DDA1 DET1 and DDB1 associated 1, RBM39 RNA-binding motif protein 39, ClpC AAA+ unfoldase, mSA-Kre monomeric streptavidin fused Kre protein

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