Bioengineered materials with selective antimicrobial toxicity in biomedicine

Makvandi, Pooyan; Song, Hao; Yiu, Cynthia K. Y.; Sartorius, Rossella; Zare, Ehsan Nazarzadeh; Rabiee, Navid; Wu, Wei-Xi; Paiva-Santos, Ana Cláudia; Wang, Xiang-Dong; Yu, Cheng-Zhong; Tay, Franklin R.

doi:10.1186/s40779-023-00443-1

Military Medical Research

Table 2 Some antimicrobial materials and their effects on immune system

From: Bioengineered materials with selective antimicrobial toxicity in biomedicine

Type of material	Function	Selectivity	Type of effect on immune response	References
E. coli adherence proteins encapsulated in chitosan NPs	Antibacterial vaccine	Enterohemorrhagic E. coli O157:H7	Humoral and mucosal immune responses	[100]
E. coli outer membrane proteins immobilized on gold NPs	Antibacterial vaccine	Enterohemorrhagic E. coli O157:H7	Humoral and mucosal immune responses	[101]
Gold NPs coated with E. coli OMVs	Antibacterial vaccine	E. coli	Dendritic cell maturation, Antibody response, Th1 and Th17 T cell responses	[99]
BSA-coated NPs with K. pneumoniae OMVs	Antibacterial vaccine	K. pneumoniae	Antibody response, T cell response	[98]
Silver NPs	Antimicrobial	S. Enteritidis	IL-1, IL-6 and TNF-α cytokine release by macrophages	[107] [111]
3-aminopropyltriethoxysilane ZnO NPs	Antimicrobial	Gram-negative bacteria	IL-6, IL-1β, IL-8 and TNF-α cytokine release	[108]
Silver-containing nanocapsules of titanium dioxide	Antimicrobial	E. coli, S. aureus	Macrophage phagocytosis enhancement	[110]
Silver-containing silica nanorattles	Antimicrobial	E. coli, S. aureus	DCs phagocytosis enhancement	[112]
Silver NPs-loaded TiO₂ nanotubes	Antimicrobial	-	Macrophage polarization towards the M2 phenotype	[113]
β-peptide polymer (20:80 Bu:DM)	Antimicrobial	P. aeruginosa	Anti-inflammatory activity, suppression of LPS-induced TNF-α. Anti-inflammatory IL-1RA induction. Monocytes/macrophages recruitment	[118]
Peptide19-2.5 and Pep19-4LF derivative	Anti-LPS	Gram-negative and Gram-positive	Anti-inflammatory activity. IL-6 reduction, expression of maturation markers and DC migration inhibition	[119]
Lactoferrin (1–11) peptide	Antimicrobial anti-LPS	S. aureus, C. albicans, A. fumigatus	Enhanced phagocytosis and DC maturation, IL-6, IL-10 cytokine release, Th17 T cell polarization	[121]
Lactoferricin peptides	Antimicrobial, anti-LPS	-	Anti-inflammatory activity, TNF-α and IL-6 reduction	[124]
Short triazine-based amphipathic polymers	Antimicrobial	P. aeruginosa	Anti-inflammatory activity, reduce mast cell infiltration and TGF-β, TNF-α, iNOS, COX-2 levels. Regulates the Th1/Th2 and serum IgE and IgG2a levels	[125]
KR-12 peptide immobilized on titanium surfaces	Antimicrobial	S. epidermidis	Anti-inflammatory activity, modulates macrophage activation and IL-1β and TNF-α release	[126]
Lauryl-LF11 peptide	Antimicrobial, anti-LPS	S. enterica	Anti-inflammatory activity. Reduction of LPS-induced TNF-α release in human mononuclear cells	[127]
Granulysin-derived peptide Gran1	Antimicrobial, anti-LPS	M. tuberculosis	Macrophage phagocytosis enhancement	[128]

NP nanoparticle, OMV outer membrane vescicle, BSA bovine serum albumin, DC dendritic cells, Th T helper, IL interleukin, TNF tumor necrosis factor, LPS lipopolysaccharide, E. coli Escherichia coli, K. pneumoniae Klebsiella pneumoniae, S. Enteritidis Salmonella Enteritidis, S. aureus Staphylococcus aureus, P. aeruginosa Pseudomonas aeruginosa, C. albicans Candida albicans, A. fumigatus Aspergillus fumigatus, S. epidermidis Staphylococcus epidermidis, S. enterica Salmonella enterica, M. tuberculosis Mycobacterium tuberculosis

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ISSN: 2054-9369

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