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Fig. 2 | Military Medical Research

Fig. 2

From: Adhesive hydrogels in osteoarthritis: from design to application

Fig. 2

Main adhesion mechanisms, components, and potential functions of adhesive hydrogels in OA therapy. a Two common adhesion mechanisms behind adhesive hydrogels for OA therapy. The first one is mechanical interlocking formed on macro level. Irregular tissue or pores are needed for relatively weak adhesiveness. The second is intermolecular bonding including non-covalent and covalent ones formed on molecular level. Non-covalent bonding includes hydrogen bonding from a hydrogen atom covalently bonded to electronegative atom such as N and O, and electrostatic attraction between two oppositely charged molecules. Covalent bonding includes biological and biochemical couplings (Amide bond and Disulfide bond), Schiff-base, NHS-ester, Thiol-ene and Phenol groups. b A list of components for fabricating adhesive hydrogels, including nature-based polymers (Gelatin, HA, CS and their modification products, etc.) and synthetic polymers (PVA, PLGA, various modification products of PEG, etc.). c Potential functions of adhesive hydrogels in OA therapy. OA osteoarthritis, CS chondroitin sulfate, GelMA methacrylated gelatin, HA hyaluronic acid, HA-NB o-nitrobenzyl alcohol-modified HA, PEG polyethylene glycol, PVA polyvinyl alcohol, PLGA polylactic-co-glycolic, ECM extra cellular matrix. It was created utilizing the templates on BioRender.com as a reference

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