Fig. 4

Functional enrichment of the common periodic transcripts. a Venn diagram showing the common periodic transcripts of HeLa, HCT116 and MDA-MB-231 cells. b Heatmap showing the 1280 transcripts with the same periodic expression patterns in HeLa, HCT116 and MDA-MB-231 cells. Each column represents a cell sample. They are samples at consecutive time points after cell cycle synchronization in G₁/S phase. From left to right are samples in each phase of G₁/S-S-G₂/M-G₁. Each row represents a transcript, and the transcripts from top to bottom are the transcripts highly expressed in each phase of G₁/S-S-G₂/M-G₁. The heatmap is sorted according to the cell cycle phase of highly expressed transcripts in HCT116 cells, and the transcript order of HeLa and MDA-MB-231 is consistent with that of HCT116. c, d Bubble plots showing the top 10 GO-BP and KEGG pathway terms of the 1223 genes corresponding to the 1280 periodic transcripts. GO-BP Gene Ontology Biological Process, KEGG Kyoto Encyclopedia of Genes and Genomes