Item | Baseline | Week 6 | Week 12 | Group F(P) | Time F(P) | Group × time F(P) | |||
---|---|---|---|---|---|---|---|---|---|
Amisulpride | Placebo | Amisulpride | Placebo | Amisulpride | Placebo | ||||
TESS scorea | 4.83 ± 3.81 | 4.93 ± 3.50 | 6.40 ± 4.82 | 5.40 ± 3.59 | 6.30 ± 4.76 | 5.55 ± 3.63 | 2.98 (0.42) | 0.04 (0.96) | 0.79 (0.38) |
BMI | 24.76 ± 3.47 | 23.06 ± 2.84 | 24.82 ± 3.39 | 23.10 ± 2.81 | 24.96 ± 3.45 | 23.19 ± 2.95 | 5.24 (0.03) | 1.50 (0.23) | 0.55 (0.58) |
WBCa (× 109) | 6.00 ± 1.21 | 6.53 ± 1.91 | 6.11 ± 1.45 | 6.59 ± 1.52 | 6.06 ± 1.49 | 7.06 ± 1.71 | 2.96 (0.09) | 0.08 (0.92) | 1.14 (0.33) |
Neutrophilsa (× 109) | 3.77 ± 0.81 | 4.15 ± 1.62 | 3.57 ± 1.22 | 4.12 ± 1.23 | 3.66 ± 1.00 | 4.56 ± 1.60 | 4.45 (0.04) | 0.74 (0.48) | 1.40 (0.25) |
RBCa (× 1012) | 4.11 ± 0.53 | 4.26 ± 0.51 | 4.14 ± 0.55 | 4.24 ± 0.50 | 4.20 ± 0.53 | 4.18 ± 0.46 | 0.68 (0.41) | 0.04 (0.96) | 1.81 (0.17) |
Hba (g/L) | 121.43 ± 13.60 | 128.85 ± 13.51 | 123.00 ± 14.33 | 129.62 ± 11.06 | 123.54 ± 14.16 | 129.62 ± 12.54 | 4.67 (0.03) | 2.67 (0.08) | 0.35 (0.70) |
PLTa (× 109) | 240.63 ± 57.46 | 261.26 ± 77.67 | 239.54 ± 63.58 | 261.59 ± 68.07 | 248.97 ± 69.62 | 252.59 ± 73.09 | 1.31 (0.26) | 1.28 (0.28) | 1.84 (0.17) |
ALTa (U/L) | 16.80 ± 10.57 | 19.97 ± 12.87 | 18.09 ± 13.33 | 19.97 ± 12.98 | 18.46 ± 11.64 | 21.88 ± 11.60 | 1.84 (0.18) | 0.19 (0.83) | 0.25 (0.78) |
ASTa (U/L) | 20.46 ± 6.35 | 23.38 ± 10.05 | 21.37 ± 9.81 | 19.85 ± 5.68 | 18.29 ± 4.96 | 21.85 ± 7.37 | 1.99 (0.16) | 0.14 (0.87) | 4.52 (0.02) |
BUNa (mmol/L) | 4.49 ± 1.20 | 4.03 ± 1.27 | 4.31 ± 0.90 | 4.35 ± 1.20 | 4.34 ± 1.39 | 4.18 ± 1.09 | 1.25 (0.27) | 0.18 (0.84) | 1.93 (0.15) |
Cra (μmol/L) | 62.74 ± 11.52 | 73.68 ± 15.22 | 63.34 ± 11.14 | 69.91 ± 19.03 | 62.17 ± 11.27 | 70.32 ± 16.36 | 6.31 (0.01) | 0.29 (0.75) | 2.01 (0.14) |
Ura (μmol/L) | 292.86 ± 91.53 | 352.26 ± 122.22 | 283.91 ± 90.78 | 359.24 ± 105.86 | 281.57 ± 98.38 | 333.00 ± 90.51 | 6.90 (0.01) | 0.74 (0.48) | 2.05 (0.14) |
Glucosea (mmol/L) | 5.11 ± 0.93 | 5.59 ± 2.02 | 5.29 ± 0.89 | 5.26 ± 0.83 | 5.34 ± 1.00 | 5.47 ± 1.02 | 0.45 (0.51) | 1.09 (0.34) | 0.93 (0.40) |
TGa (mmol/L) | 1.31 ± 0.53 | 1.59 ± 0.66 | 1.54 ± 0.74 | 1.74 ± 0.67 | 1.31 ± 0.68 | 1.62 ± 0.95 | 3.21 (0.08) | 0.50 (0.61) | 0.42 (0.66) |
TCa (mmol/L) | 4.03 ± 0.71 | 4.18 ± 0.94 | 4.03 ± 0.79 | 4.24 ± 0.86 | 4.03 ± 0.86 | 4.06 ± 0.65 | 0.11 (0.74) | 3.14 (0.05) | 1.93 (0.15) |
HDLCa (mmol/L) | 1.23 ± 0.43 | 1.18 ± 0.39 | 1.34 ± 0.48 | 1.18 ± 0.39 | 1.34 ± 0.48 | 1.12 ± 0.33 | 3.19 (0.08) | 0.87 (0.43) | 2.00 (0.14) |
LDLCa (mmol/L) | 2.11 ± 0.76 | 2.32 ± 0.95 | 2.23 ± 0.69 | 2.38 ± 0.74 | 2.17 ± 0.71 | 2.38 ± 0.70 | 0.81 (0.37) | 0.31 (0.74) | 0.10 (0.90) |
QTc intervala (ms) | 384.80 ± 30.67 | 411.79 ± 31.73 | 381.03 ± 29.58 | 413.24 ± 32.76 | 389.14 ± 31.77 | 408.41 ± 40.47 | 10.75 (0.002) | 1.18 (0.31) | 3.04 (0.06) |