Table 2 The scores of PANSS, RBANS, SANS and CGI at baseline, week 6 and week 12 follow-up in amisulpride and placebo groups
Item | Baseline | Week 6 | Week 12 | Group F(P) | Time F(P) | Group × time F(P) | |||
|---|---|---|---|---|---|---|---|---|---|
Amisulpride | Placebo | Amisulpride | Placebo | Amisulpride | Placebo | ||||
PANSS total score | 82.28 ± 8.54 | 79.53 ± 6.71 | 70.75 ± 9.47 | 77.75 ± 5.99 | 73.68 ± 10.35 | 77.63 ± 6.86 | 3.51 (0.07) | 1.25 (0.29) | 11.75 (< 0.001) |
  P subscore | 19.40 ± 6.54 | 20.73 ± 3.90 | 16.33 ± 3.94 | 20.35 ± 4.15 | 15.93 ± 4.36 | 20.25 ± 4.56 | 10.99 (0.001) | 0.09 (0.92) | 3.66 (0.03) |
  N subscore | 21.15 ± 7.45 | 18.98 ± 4.69 | 20.27 ± 5.95 | 18.93 ± 3.74 | 19.95 ± 6.63 | 18.38 ± 4.16 | 3.08 (0.08) | 0.73 (0.49) | 0.91 (0.41) |
  G subscore | 41.48 ± 6.33 | 39.83 ± 3.55 | 34.40 ± 5.38 | 38.48 ± 3.59 | 34.38 ± 6.01 | 39.00 ± 3.76 | 5.43 (0.02) | 1.27 (0.29) | 9.03 (< 0.001) |
RBANS total score | 59.38 ± 7.71 | 60.28 ± 10.14 | 63.20 ± 8.88 | 61.75 ± 10.72 | 65.03 ± 8.31 | 61.25 ± 9.98 | 0.48 (0.49) | 1.49 (0.23) | 3.54 (0.03) |
  Immediate memory | 59.43 ± 9.65 | 59.83 ± 11.68 | 61.83 ± 9.26 | 59.50 ± 10.66 | 63.50 ± 8.68 | 60.63 ± 9.83 | 0.52 (0.47) | 0.07 (0.93) | 2.11 (0.13) |
  Visuospatial/construction | 67.50 ± 12.23 | 68.65 ± 11.97 | 73.30 ± 13.93 | 70.33 ± 14.29 | 72.43 ± 12.02 | 68.35 ± 12.22 | 0.29 (0.60) | 1.06 (0.35) | 1.63 (0.20) |
  Language | 71.15 ± 14.02 | 71.63 ± 13.86 | 78.05 ± 11.66 | 74.55 ± 12.99 | 81.20 ± 10.20 | 72.38 ± 12.68 | 2.35 (0.13) | 0.92 (0.40) | 5.49 (0.006) |
  Attention | 73.65 ± 11.58 | 73.75 ± 13.94 | 76.25 ± 11.68 | 72.55 ± 11.89 | 74.25 ± 10.90 | 73.33 ± 11.57 | 0.16 (0.69) | 2.33 (0.10) | 2.37 (0.10) |
  Delayed memory | 57.93 ± 9.68 | 61.03 ± 11.52 | 62.15 ± 10.14 | 63.38 ± 13.06 | 61.48 ± 9.72 | 63.05 ± 13.37 | 0.60 (0.44) | 0.47 (0.63) | 0.86 (0.43) |
SANS | 45.18 ± 15.38 | 43.13 ± 14.36 | 44.78 ± 14.88 | 44.13 ± 13.56 | 43.88 ± 13.14 | 44.68 ± 14.78 | 0.20 (0.66) | 1.03 (0.36) | 2.83 (0.07) |
CGI-S | 5.03 ± 0.70 | 4.90 ± 0.71 | 4.20 ± 0.61 | 4.63 ± 0.59 | 4.20 ± 0.61 | 4.78 ± 0.66 | 3.50 (0.07) | 1.26 (0.29) | 10.85 (< 0.001) |
CGI-I | 4.05 ± 0.22 | 4.03 ± 0.16 | 3.48 ± 0.92 | 3.90 ± 0.55 | 3.48 ± 0.96 | 4.03 ± 0.16 | 4.41 (0.04) | 0.17 (0.85) | 4.16 (0.02) |
CGI-E | 13.60 ± 0.50 | 13.58 ± 0.50 | 10.88 ± 3.58 | 12.98 ± 1.92 | 10.88 ± 3.58 | 13.58 ± 0.50 | 15.38 (< 0.001) | 0.52 (0.60) | 12.17 (< 0.001) |