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Fig. 8 | Military Medical Research

Fig. 8

From: Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias

Fig. 8

Schematic showing proposed signaling involving PIASy-mediated Cav-3 SUMOylation effects on reperfusion arrhythmias. PIASy-mediated Cav-3 SUMOylation by SUMO2/3 controls the magnitude of Cav-3/Nav1.5 interaction, which affects Nav1.5 abundance on cardiomyocyte membrane and modulate lethal reperfusion arrhythmias. Cav-3 caveolin-3, Nav1.5 voltage-gated sodium channel 1.5, PIASy protein inhibitor of activated STAT Y, shRNA short hairpin RNA

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Military Medical Research

ISSN: 2054-9369