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Fig. 6 | Military Medical Research

Fig. 6

From: Cardiac-targeted PIASy gene silencing mediates deSUMOylation of caveolin-3 and prevents ischemia/reperfusion-induced Nav1.5 downregulation and ventricular arrhythmias

Fig. 6

Effects of PIASy silencing on P duration, PR interval, QRS duration, and QTc values during I/R. a Changes in P duration, PR interval, QRS duration, and QTc values during I/R. b Representative changes in QRS waves and QT intervals (upper panel) in ECG, and statistical analyses of QRS durations and QTc values (bottom panel) at 20 min after ischemia and 1 h after reperfusion. Values are expressed as the mean ± standard error of the mean (n = 10). *P < 0.05, **P < 0.01, two-way ANOVA. ANOVA analysis of variance, ECG electrocardiography, isch ischemia, I/R ischemia/reperfusion, QTc corrected QT interval, PIASy protein inhibitor of activated STAT Y, rep reperfusion, shRNA short hairpin RNA

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Military Medical Research

ISSN: 2054-9369